Abstract:
:Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or downstream of inflammasome assembly, serving as the principal enzymes that control activities of these organelles. In this review, we discuss mechanisms of inflammasome assembly and signaling. We posit that upstream regulatory proteins, classically known as pattern-recognition receptors, operate to assess infectious and non-infectious threats to the host. Threat assessment is achieved through two general strategies: (1) direct binding of receptors to microbial or host-derived ligands or (2) indirect detection of changes in cellular homeostasis. Upon activation, these upstream regulatory factors seed the assembly of inflammasomes, leading to IL-1 family cytokine release from living (hyperactive) or dead (pyroptotic) cells. The molecular and physiological consequences of these distinct cell fate decisions are discussed.
journal_name
Immunityjournal_title
Immunityauthors
Evavold CL,Kagan JCdoi
10.1016/j.immuni.2019.08.005subject
Has Abstractpub_date
2019-10-15 00:00:00pages
609-624issue
4eissn
1074-7613issn
1097-4180pii
S1074-7613(19)30331-0journal_volume
51pub_type
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