当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Treg cells acquire new directions, cytokines navigate.

Treg cells acquire new directions, cytokines navigate.

Abstract：

:Foxp3(+) Treg cells express transcription factors normally expressed by specific T helper cells at sites of inflammation. In this issue of Immunity, Koch et al. (2012) and Hall et al. (2012) demonstrate that IFN-γ and IL-27 distinctly induces T-bet(+) Treg cells via STAT-1 transcription factor activation.

journal_name

Immunity

journal_title

Immunity

authors

Ohkura N,Sakaguchi S

doi

10.1016/j.immuni.2012.09.004

subject

Has Abstract

pub_date

2012-09-21 00:00:00

pages

443-4

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(12)00385-8

journal_volume

37

pub_type

评论,杂志文章

相关文献

IMMUNITY文献大全
  • Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies.

    abstract：:Commensal microorganisms influence malignant progression by altering systemic inflammation. New data from two groups (Vétizou et al., 2015; Sivan et al., 2015) indicate that the abundance of specific commensal bacterial species enhances the anti-cancer activity of immune checkpoint inhibitors. ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.11.014

    authors： Conejo-Garcia JR,Rutkowski MR

    更新日期：2015-12-15 00:00:00

  • Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

    abstract：:Regulatory T cell-mediated dominant tolerance has been demonstrated to play an important role in the prevention of autoimmunity. Here, we present data arguing that the forkhead transcription factor Foxp3 acts as the regulatory T cell lineage specification factor and mediator of the genetic mechanism of dominant tolera...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.01.016

    authors： Fontenot JD,Rasmussen JP,Williams LM,Dooley JL,Farr AG,Rudensky AY

    更新日期：2005-03-01 00:00:00

  • Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition.

    abstract：:IgE antibodies may be protective in parasite immunity, but their aberrant production can lead to allergic disease and life-threatening anaphylaxis. Despite the importance of IgE regulation, few studies have directly examined the B cells that express IgE, because these cells are rare and difficult to detect. Here, we d...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.02.009

    authors： Yang Z,Sullivan BM,Allen CD

    更新日期：2012-05-25 00:00:00

  • Dendritic cells in vivo: a key target for a new vaccine science.

    abstract：:Dendritic cells (DCs) are the antigen presenting cells that initiate and regulate immunity. By studying these cells in vivo, we will be able to move beyond standard approaches and design vaccines that directly harness the elaborate properties of DCs to control immunity. ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.08.001

    authors： Steinman RM

    更新日期：2008-09-19 00:00:00

  • Dysfunctional HDL takes its toll in chronic kidney disease.

    abstract：:Why patients with chronic kidney disease have elevated cardiovascular risk remains elusive. In this issue of Immunity, Speer et al. (2013) show that natural modification of high density lipoprotein promotes hypertension through a Toll-like receptor-dependent mechanism. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2013.03.006

    authors： Moore KJ,Fisher EA

    更新日期：2013-04-18 00:00:00

  • Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells.

    abstract：:Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this study, we find that IL-17A-defective mice or mice treated with anti-IL-17A at induction of experi...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.01.002

    authors： McGinley AM,Sutton CE,Edwards SC,Leane CM,DeCourcey J,Teijeiro A,Hamilton JA,Boon L,Djouder N,Mills KHG

    更新日期：2020-02-18 00:00:00

  • mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25.

    abstract：:mel-18 is a mammalian Polycomb group gene encoding a transcriptional repressor with tumor suppressive activity. Overexpression of mel-18 in mice results in cell cycle arrest of B cells upon B cell receptor stimulation with downregulation of c-myc. This phenotype is rescued in mel-18/c-myc double-transgenic mice, sugge...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80627-5

    authors： Tetsu O,Ishihara H,Kanno R,Kamiyasu M,Inoue H,Tokuhisa T,Taniguchi M,Kanno M

    更新日期：1998-10-01 00:00:00

  • Caspase-8: clipping off RIG-I signaling.

    abstract：:Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2011.03.011

    authors： Roth S,Ruland J

    更新日期：2011-03-25 00:00:00

  • Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.

    abstract：:Major Histocompatibility Complex (MHC) class II molecules, including Human Leukocyte Antigen (HLA)-DR, present peptide fragments from proteins degraded in the endocytic pathway. HLA-DR is targeted to late-endocytic structures named MHC class II-containing Compartments (MIIC), where it interacts with HLA-DM. This chape...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.01.006

    authors： Zwart W,Griekspoor A,Kuijl C,Marsman M,van Rheenen J,Janssen H,Calafat J,van Ham M,Janssen L,van Lith M,Jalink K,Neefjes J

    更新日期：2005-02-01 00:00:00

  • Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells.

    abstract：:Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.05.006

    authors： Araki Y,Wang Z,Zang C,Wood WH 3rd,Schones D,Cui K,Roh TY,Lhotsky B,Wersto RP,Peng W,Becker KG,Zhao K,Weng NP

    更新日期：2009-06-19 00:00:00

  • Silence of the ROS.

    abstract：:Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2016.02.027

    authors： Agudo J,Brown BD

    更新日期：2016-03-15 00:00:00

  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

    abstract：:T cell activation induces functional changes in cell shape and cytoskeletal architecture. To facilitate the collection of dynamic, high-resolution images of activated T cells, we plated T cells on coverslips coated with antibodies to the T cell receptor (TCR). Using these images, we were able to quantitate the morphol...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00112-1

    authors： Bunnell SC,Kapoor V,Trible RP,Zhang W,Samelson LE

    更新日期：2001-03-01 00:00:00

  • FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

    abstract：:The mechanistic links between genetic variation and autoantibody production in autoimmune disease remain obscure. Autoimmune lymphoproliferative syndrome (ALPS) is caused by inactivating mutations in FAS or FASL, with autoantibodies thought to arise through failure of FAS-mediated removal of self-reactive germinal cen...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.04.010

    authors： Butt D,Chan TD,Bourne K,Hermes JR,Nguyen A,Statham A,O'Reilly LA,Strasser A,Price S,Schofield P,Christ D,Basten A,Ma CS,Tangye SG,Phan TG,Rao VK,Brink R

    更新日期：2015-05-19 00:00:00

  • Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.

    abstract：:Recent evidence has suggested that signals other than those from Toll-like receptors (TLRs) could contribute to the elicitation of antigen-specific immunity. Therefore, we examined the role of the Nod-like receptor (NLR) family member, Nod1, in the generation of adaptive immune responses. Our findings show that innate...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.03.009

    authors： Fritz JH,Le Bourhis L,Sellge G,Magalhaes JG,Fsihi H,Kufer TA,Collins C,Viala J,Ferrero RL,Girardin SE,Philpott DJ

    更新日期：2007-04-01 00:00:00

  • Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.

    abstract：:Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B c...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90048-9

    authors： Liu YJ,Barthélémy C,de Bouteiller O,Arpin C,Durand I,Banchereau J

    更新日期：1995-03-01 00:00:00

  • Dendritic cells permit identification of genes encoding MHC class II-restricted epitopes of transplantation antigens.

    abstract：:Minor or histocompatibility (H) antigens are recognized by CD4+ and CD8+ T lymphocytes as short polymorphic peptides associated with MHC molecules. They are the targets of graft versus host and graft versus leukemia responses following bone marrow transplantation between HLA-identical siblings. Several genes encoding ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80221-6

    authors： Scott D,Addey C,Ellis P,James E,Mitchell MJ,Saut N,Jurcevic S,Simpson E

    更新日期：2000-06-01 00:00:00

  • Microglia: You'll Never Walk Alone!

    abstract：:In this issue of Immunity, Mrdjen et al. (2018) use high-dimensional single-cell proteomics and high parametric mass cytometry to provide insight into the long-lasting issue of how to identify and characterize both resident and recruited leukocyte populations in healthy, aged, and diseased CNS. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2018.02.009

    authors： Villacampa N,Heneka MT

    更新日期：2018-02-20 00:00:00

  • Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.

    abstract：:Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of Plasmodium falciparum (Pf) sporozoites, can protect from malaria in animal models but protective humoral immunity is difficult to induce in humans. Here we cloned and characterized rare affinity-matured human NANP-reacti...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.11.007

    authors： Triller G,Scally SW,Costa G,Pissarev M,Kreschel C,Bosch A,Marois E,Sack BK,Murugan R,Salman AM,Janse CJ,Khan SM,Kappe SHI,Adegnika AA,Mordmüller B,Levashina EA,Julien JP,Wardemann H

    更新日期：2017-12-19 00:00:00

  • Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.

    abstract：:Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates TLR9, inducing the pathogenic secretion of type I interferons (IFNs) from plasmacytoid dendritic cells (pDCs). Here, we found that in response to DNA-containing...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.09.014

    authors： Henault J,Martinez J,Riggs JM,Tian J,Mehta P,Clarke L,Sasai M,Latz E,Brinkmann MM,Iwasaki A,Coyle AJ,Kolbeck R,Green DR,Sanjuan MA

    更新日期：2012-12-14 00:00:00

  • Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination.

    abstract：:The products of V(D)J recombination are coding and signal joints. We show that the nucleotide composition of the coding ends affects V(D)J recombination. The presence of Ts at the 5' end of either the 12 mer or the 23 mer recombination signal sequence (RSS) greatly decreases coding and signal joint formation, and Ts a...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90146-9

    authors： Ezekiel UR,Engler P,Stern D,Storb U

    更新日期：1995-04-01 00:00:00

  • A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures.

    abstract：:Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes have primarily focused on a limited number of parameters in blood, representing an incomplete view of the human immune system. Here, we hav...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.07.007

    authors： Wong MT,Ong DE,Lim FS,Teng KW,McGovern N,Narayanan S,Ho WQ,Cerny D,Tan HK,Anicete R,Tan BK,Lim TK,Chan CY,Cheow PC,Lee SY,Takano A,Tan EH,Tam JK,Tan EY,Chan JK,Fink K,Bertoletti A,Ginhoux F,Curotto de Lafail

    更新日期：2016-08-16 00:00:00

  • Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release.

    abstract：:Acute lung injury (ALI) remains a serious health issue with little improvement in our understanding of the pathophysiology and therapeutic approaches. We investigated the mechanism that lipopolysaccharide (LPS) induces early neutrophil recruitment to lungs and increases pulmonary vascular permeability during ALI. Intr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.03.007

    authors： Dagvadorj J,Shimada K,Chen S,Jones HD,Tumurkhuu G,Zhang W,Wawrowsky KA,Crother TR,Arditi M

    更新日期：2015-04-21 00:00:00

  • Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells.

    abstract：:By stimulating human lymphocytes with an autologous renal carcinoma, we obtained CTL recognizing an antigen derived from a novel, ubiquitous protein. The CTL failed to lyse autologous EBV-transformed B cells, even though the latter express the protein. This is due to the presence in these cells of immunoproteasomes, w...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80163-6

    authors： Morel S,Lévy F,Burlet-Schiltz O,Brasseur F,Probst-Kepper M,Peitrequin AL,Monsarrat B,Van Velthoven R,Cerottini JC,Boon T,Gairin JE,Van den Eynde BJ

    更新日期：2000-01-01 00:00:00

  • Interferon-λ: Immune Functions at Barrier Surfaces and Beyond.

    abstract：:When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs). Although IFN-λ stimulates expression of antiviral ISGs preferentially i...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2015.07.001

    authors： Lazear HM,Nice TJ,Diamond MS

    更新日期：2015-07-21 00:00:00

  • CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells.

    abstract：:The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and promotes anti-tumor immunity in pre-clinical models. Here, we examined the role of CD226 in the function of tumor-infiltrating lymphocytes (TILs) and resistance to immunotherapy. In murine tumors, a large proportion of CD8+ TILs ha...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.09.010

    authors： Braun M,Aguilera AR,Sundarrajan A,Corvino D,Stannard K,Krumeich S,Das I,Lima LG,Meza Guzman LG,Li K,Li R,Salim N,Jorge MV,Ham S,Kelly G,Vari F,Lepletier A,Raghavendra A,Pearson S,Madore J,Jacquelin S,Effern M,

    更新日期：2020-10-13 00:00:00

  • Priming the pump: adhesion enhances T cell antigen receptor-induced signaling.

    abstract：:In this issue of Immunity, Conche et al. (2009) define an antigen-independent signaling pathway that is dependent on cyclic adenosine monophosphate and extracellular signal-regulated kinase and T cells for subsequent T cell antigen receptor signaling. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2008.12.007

    authors： Kortum RL,Samelson LE

    更新日期：2009-01-16 00:00:00

  • Inflammasome-Dependent Induction of Adaptive NK Cell Memory.

    abstract：:Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-la...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.05.008

    authors： van den Boorn JG,Jakobs C,Hagen C,Renn M,Luiten RM,Melief CJ,Tüting T,Garbi N,Hartmann G,Hornung V

    更新日期：2016-06-21 00:00:00

  • The LTi cell, an immunologic chameleon.

    abstract：:Lymphoid tissue inducer (LTi) cells are key components of the machinery required for the construction of the lymphoid structures underlying immune responses. In this issue of Immunity, Vonarbourg et. al. (2010) describe how these cells assume several different guises, each associated with different LTi functions. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2010.11.016

    authors： Strober W

    更新日期：2010-11-24 00:00:00

  • microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.

    abstract：:microRNA-155 (miR-155) is expressed by cells of the immune system after activation and has been shown to be required for antibody production after vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymus-dependent and -independent antigens. B cells lackin...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.10.009

    authors： Vigorito E,Perks KL,Abreu-Goodger C,Bunting S,Xiang Z,Kohlhaas S,Das PP,Miska EA,Rodriguez A,Bradley A,Smith KG,Rada C,Enright AJ,Toellner KM,Maclennan IC,Turner M

    更新日期：2007-12-01 00:00:00

  • A Little Fiber Goes a Long Way.

    abstract：:In this issue of Immunity, Trompette et al. (2018) show that dietary fiber and short chain fatty acids reduce influenza A virus-associated immunopathology by enhancing CD8+ T cell effector function and by promoting the differentiation of alternatively activated macrophages. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2018.05.001

    authors： Castillo PAC,Hand TW

    更新日期：2018-05-15 00:00:00