当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Multistage regulation of Th1-type immune responses by the transcription factor IRF-1.

Multistage regulation of Th1-type immune responses by the transcription factor IRF-1.

Abstract：

:Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects in multiple cell types, namely impaired production of interleukin-12 by macrophages, hyporesponsiveness of CD4+ T cells to interleukin-12, and defective development of natural killer cells. These results indicate the involvement of IRF-1 in multiple stages of the Th1 limb of the immune response.

journal_name

Immunity

journal_title

Immunity

authors

Taki S,Sato T,Ogasawara K,Fukuda T,Sato M,Hida S,Suzuki G,Mitsuyama M,Shin EH,Kojima S,Taniguchi T,Asano Y

doi

10.1016/s1074-7613(00)80443-4

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

673-9

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80443-4

journal_volume

6

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo.

    abstract：:Immunoglobulin G (IgG) antibodies confer protection against pathogenic microorganisms, serve as therapeutics in tumor therapy, and are involved in destruction of healthy tissues during autoimmune diseases. Understanding the molecular pathways and effector cell types involved in antibody-mediated effector functions is ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.11.009

    authors： Biburger M,Aschermann S,Schwab I,Lux A,Albert H,Danzer H,Woigk M,Dudziak D,Nimmerjahn F

    更新日期：2011-12-23 00:00:00

  • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

    abstract：:We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the presence of TLR3, TLR4, or TLR9 stimuli. Treg can be substituted by TGFbeta1, which, together with the proinflammatory cytokine IL-6, sup...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.01.001

    authors： Veldhoen M,Hocking RJ,Atkins CJ,Locksley RM,Stockinger B

    更新日期：2006-02-01 00:00:00

  • Effect of TAP on the generation and intracellular trafficking of peptide-receptive major histocompatibility complex class I molecules.

    abstract：:Using a fluorescein-conjugated antigenic peptide, peptide-receptive H-2Kb MHC class I molecules were found throughout the secretory pathways of RMA cells and peptide transporter (TAP)-deficient derivative cells (RMA/S). RMA/S cells displayed higher levels of intracellular peptide-receptive molecules, while, surprising...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(95)80014-x

    authors： Day PM,Esquivel F,Lukszo J,Bennink JR,Yewdell JW

    更新日期：1995-02-01 00:00:00

  • Clec2d Joins the Cell Death Sensor Ranks.

    abstract：:Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necro...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.12.015

    authors： Del Fresno C,Sancho D

    更新日期：2020-01-14 00:00:00

  • Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen.

    abstract：:To understand how orally introduced antigen regulates peripheral immune responses, we fed cytochrome c protein to mice transgenic for the beta chain of a cytochrome c-specific TCR and followed the antigen-specific T cell responses with a cyt c/I-Ek tetramer staining reagent. We find that within 6 hr of cytochrome c ad...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80571-3

    authors： Gütgemann I,Fahrer AM,Altman JD,Davis MM,Chien YH

    更新日期：1998-06-01 00:00:00

  • Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell development.

    abstract：:Invariant chain (Ii)-negative mice exhibit defects in MHC class II assembly and transport that results in reduced levels of surface class II, altered antigen presentation, and inefficient positive selection of CD4+ T cells. Many CD4+ T cells that do mature in Ii-negative mice express a cell surface phenotype consisten...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90120-5

    authors： Naujokas MF,Arneson LS,Fineschi B,Peterson ME,Sitterding S,Hammond AT,Reilly C,Lo D,Miller J

    更新日期：1995-09-01 00:00:00

  • Somatic hypermutation in the heavy chain locus correlates with transcription.

    abstract：:Three mutant immunoglobulin heavy chain (IgH) insertion mice were generated in which a targeted nonfunctional IgH passenger transgene was either devoid of promoter (pdelta) or was placed under the transcriptional control of either its own RNA polymerase II-dependent IgH promoter (pII) or a RNA polymerase I-dependent p...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80592-0

    authors： Fukita Y,Jacobs H,Rajewsky K

    更新日期：1998-07-01 00:00:00

  • Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

    abstract：:The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deleti...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2004.10.014

    authors： Liston A,Lesage S,Gray DH,O'Reilly LA,Strasser A,Fahrer AM,Boyd RL,Wilson J,Baxter AG,Gallo EM,Crabtree GR,Peng K,Wilson SR,Goodnow CC

    更新日期：2004-12-01 00:00:00

  • Identity crisis: it's not just Foxp3 anymore.

    abstract：:What does it take to make a regulatory T (Treg) cell? In this issue of Immunity, Ohkura et al. show that Treg-cell-specific CpG hypomethylation and Foxp3 expression are independent events required for Treg cell development, stability, and full suppressive activity. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2012.10.012

    authors： Delgoffe GM,Bettini ML,Vignali DA

    更新日期：2012-11-16 00:00:00

  • SHIP modulates immune receptor responses by regulating membrane association of Btk.

    abstract：:Membrane recruitment of SHIP is responsible for the inhibitory signal generated by FcgammaRIIB coligation to the BCR. By reducing the level of PIP3, SHIP regulates the association of the tyrosine kinase Btk with the membrane through PH domain-phosphoinositol lipid interactions. Inhibition of BCR signaling by either Fc...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80555-5

    authors： Bolland S,Pearse RN,Kurosaki T,Ravetch JV

    更新日期：1998-04-01 00:00:00

  • Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease.

    abstract：:C57BI/6 mice infected with mouse hepatitis virus, strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis. Infectious virus can be isolated only from symptomatic mice. In C57BI/6 mice, two CD8+ T cell epitopes within the MHV-JHM surface glycoprotein were previously identified. Here, we show that mutatio...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80320-9

    authors： Pewe L,Wu GF,Barnett EM,Castro RF,Perlman S

    更新日期：1996-09-01 00:00:00

  • A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex.

    abstract：:The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00288-1

    authors： Reiser JB,Grégoire C,Darnault C,Mosser T,Guimezanes A,Schmitt-Verhulst AM,Fontecilla-Camps JC,Mazza G,Malissen B,Housset D

    更新日期：2002-03-01 00:00:00

  • Bon EPOtit! S1P-Mediated EPO Signaling Whets a Macrophage's Appetite for Apoptotic Cells.

    abstract：:Phagocytes clear dying cells within an organism to prevent damaging inflammation and autoimmunity. In this issue of Immunity, Luo et al. (2016) describe how "find-me" signals from apoptotic cells induce erythropoietin signaling within macrophages to prime them for efferocytosis. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2016.01.023

    authors： Kolb JP,Martinez J

    更新日期：2016-02-16 00:00:00

  • DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions.

    abstract：:HIV-1 Envelope (Env) mediates viral-host membrane fusion after binding host-receptor CD4 and coreceptor. Soluble envelopes (SOSIPs), designed to mimic prefusion conformational states of virion-bound envelopes, are proposed immunogens for eliciting neutralizing antibodies, yet only static structures are available. To e...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.06.017

    authors： Stadtmueller BM,Bridges MD,Dam KM,Lerch MT,Huey-Tubman KE,Hubbell WL,Bjorkman PJ

    更新日期：2018-08-21 00:00:00

  • CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation.

    abstract：:Effector T cells are critical for clearance of pathogens from sites of infection. Like cytotoxic CD8(+) T cells, CD4(+) helper T cells have been shown to deliver effector molecules directionally toward the immunological synapse, suggesting that infected cells need to be engaged individually to receive effector signals...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.05.015

    authors： Müller AJ,Filipe-Santos O,Eberl G,Aebischer T,Späth GF,Bousso P

    更新日期：2012-07-27 00:00:00

  • Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.

    abstract：:CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses during transplanta...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.11.003

    authors： Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W

    更新日期：2017-12-19 00:00:00

  • Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase.

    abstract：:ZAP-70 and Syk are PTKs required for TCR and BCR function, respectively. Loss of the Syk PTK results in a nonfunctional BCR. We provide evidence here that ZAP-70 and Syk are functionally homologous in antigen receptor signaling by demonstrating that expression of ZAP-70 in Syk- B cells reconstitutes BCR function. Reco...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90029-2

    authors： Kong GH,Bu JY,Kurosaki T,Shaw AS,Chan AC

    更新日期：1995-05-01 00:00:00

  • Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

    abstract：:The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regu...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00419-3

    authors： Sitnicka E,Bryder D,Theilgaard-Mönch K,Buza-Vidas N,Adolfsson J,Jacobsen SE

    更新日期：2002-10-01 00:00:00

  • Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis.

    abstract：:Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Genetic studies have linked TNFSF15 polymorphisms and its protein TNF-like ligand 1A (TL1A) with IBD, but the functional role of TL1A is not known. Here, we found that adherent IBD-associ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.10.014

    authors： Castellanos JG,Woo V,Viladomiu M,Putzel G,Lima S,Diehl GE,Marderstein AR,Gandara J,Perez AR,Withers DR,Targan SR,Shih DQ,Scherl EJ,Longman RS

    更新日期：2018-12-18 00:00:00

  • Immune effector mechanisms implicated in atherosclerosis: from mice to humans.

    abstract：:According to the traditional view, atherosclerosis results from a passive buildup of cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune effector mechanisms in the pathogenesis of this disease. Both innate and adaptive immunity operate during atherogenesis and link many traditio...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2013.06.009

    authors： Libby P,Lichtman AH,Hansson GK

    更新日期：2013-06-27 00:00:00

  • Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection.

    abstract：:Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteri...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.12.020

    authors： Blériot C,Dupuis T,Jouvion G,Eberl G,Disson O,Lecuit M

    更新日期：2015-01-20 00:00:00

  • Treg cells and CTLA-4: the ball and chain of the germinal center response.

    abstract：:The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.12.009

    authors： Linterman MA,Denton AE

    更新日期：2014-12-18 00:00:00

  • T cell receptor delta gene rearrangement and T early alpha (TEA) expression in immature alpha beta lineage thymocytes: implications for alpha beta/gamma delta lineage commitment.

    abstract：:Mature T cells comprise two mutually exclusive lineages expressing heterodimeric alpha beta or gamma delta antigen receptors. During development, beta, gamma, and delta genes rearrange before alpha, and mature gamma delta cells arise in the thymus prior to alpha beta cells. The mechanism underlying commitment of immat...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80296-4

    authors： Wilson A,de Villartay JP,MacDonald HR

    更新日期：1996-01-01 00:00:00

  • The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells.

    abstract：:In this issue of Immunity, Nagashima et al., Wallrapp et al., and Xu et al. demonstrate that the neuropeptide calcitonin gene-related peptide (CGRP) fine tunes type 2 innate immune response via suppressing group 2 innate lymphoid cells (ILC2s). ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.09.015

    authors： Motomura Y,Kobayashi T,Moro K

    更新日期：2019-10-15 00:00:00

  • IL-33 Deals with the Gray Matter.

    abstract：:The central nervous system undergoes extensive postnatal synapse remodeling that is critical for the formation of mature neural circuits. In a recent issue of Science, Vainchtein et al. (2018) describe an additional role for astrocyte-derived interleukin-33 (IL-33) in promoting synapse refinement by microglia in the d...

    journal_title：Immunity

    pub_type： 信件

    doi：10.1016/j.immuni.2018.03.005

    authors： Delmas C,Dalmas E

    更新日期：2018-03-20 00:00:00

  • Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation.

    abstract：:Neutrophil accumulation is a hallmark of immune complex-mediated inflammatory disorders. Current models of neutrophil recruitment envision the capture of circulating neutrophils by activated endothelial cells. We now demonstrate that immobilized immune complexes alone support the rapid attachment of neutrophils, under...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00150-9

    authors： Coxon A,Cullere X,Knight S,Sethi S,Wakelin MW,Stavrakis G,Luscinskas FW,Mayadas TN

    更新日期：2001-06-01 00:00:00

  • Actin depletion initiates events leading to granule secretion at the immunological synapse.

    abstract：:Cytotoxic T lymphocytes (CTLs) use polarized secretion to rapidly destroy virally infected and tumor cells. To understand the temporal relationships between key events leading to secretion, we used high-resolution 4D imaging. CTLs approached targets with actin-rich projections at the leading edge, creating an initiall...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.04.013

    authors： Ritter AT,Asano Y,Stinchcombe JC,Dieckmann NM,Chen BC,Gawden-Bone C,van Engelenburg S,Legant W,Gao L,Davidson MW,Betzig E,Lippincott-Schwartz J,Griffiths GM

    更新日期：2015-05-19 00:00:00

  • Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy.

    abstract：:Human cytomegalovirus (HCMV) can suppress and evade the immune system. We have identified as a mechanism the ability of HCMV to infect dendritic cells (DC), which initiate the antiviral immune response. HCMV-infected DC show enhanced expression of costimulatory molecules. In contrast, MHC molecules are partially downr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00239-4

    authors： Raftery MJ,Schwab M,Eibert SM,Samstag Y,Walczak H,Schönrich G

    更新日期：2001-12-01 00:00:00

  • Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.

    abstract：:Epithelial cells orchestrate pulmonary homeostasis and pathogen defense and play a crucial role in the initiation of allergic immune responses. Maintaining the balance between homeostasis and inappropriate immune activation and associated pathology is particularly complex at mucosal sites that are exposed to billions ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.10.012

    authors： Denney L,Byrne AJ,Shea TJ,Buckley JS,Pease JE,Herledan GM,Walker SA,Gregory LG,Lloyd CM

    更新日期：2015-11-17 00:00:00

  • Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals.

    abstract：:Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in vivo. LMP2A blocks ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80623-8

    authors： Caldwell RG,Wilson JB,Anderson SJ,Longnecker R

    更新日期：1998-09-01 00:00:00