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CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation.

Abstract：

:Effector T cells are critical for clearance of pathogens from sites of infection. Like cytotoxic CD8(+) T cells, CD4(+) helper T cells have been shown to deliver effector molecules directionally toward the immunological synapse, suggesting that infected cells need to be engaged individually to receive effector signals. In contrast, we show here that CD4(+) T cells stably contacted a minority of infected cells, yet these interactions triggered intracellular defense mechanisms in bystander cells in vivo. By using a functional read-out, we provide evidence that this effector bystander activity extends via a gradient of IFN-γ more than 80 μm beyond the site of antigen presentation, promoting pathogen clearance in the absence of immunological synapse formation. Our results thus demonstrate that CD4(+) T cells can exert their protective activity by engaging a minority of infected cells.

journal_name

Immunity

journal_title

Immunity

authors

Müller AJ,Filipe-Santos O,Eberl G,Aebischer T,Späth GF,Bousso P

doi

10.1016/j.immuni.2012.05.015

subject

Has Abstract

pub_date

2012-07-27 00:00:00

pages

147-57

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(12)00228-2

journal_volume

37

pub_type

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