Abstract:
:CD4⁺ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4⁺ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, although it is likely that more than one mechanism might be involved. Here we have defined a specific DC subset that is involved in Th2 cell differentiation in vivo in response to a protease allergen, as well as infection with Nippostrongylus brasiliensis. We have demonstrated that this subset is controlled by the transcription factor interferon regulatory factor 4 (IRF4), which is required for their differentiation and Th2 cell-inducing function. IRF4 is known to control Th2 cell differentiation and Th2 cell-associated suppressing function in Treg cells. Our finding suggests that IRF4 also plays a role in DCs where it controls the initiation of Th2 cell responses.
journal_name
Immunityjournal_title
Immunityauthors
Gao Y,Nish SA,Jiang R,Hou L,Licona-Limón P,Weinstein JS,Zhao H,Medzhitov Rdoi
10.1016/j.immuni.2013.08.028subject
Has Abstractpub_date
2013-10-17 00:00:00pages
722-32issue
4eissn
1074-7613issn
1097-4180pii
S1074-7613(13)00380-4journal_volume
39pub_type
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