Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.

Abstract:

:CD4⁺ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4⁺ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, although it is likely that more than one mechanism might be involved. Here we have defined a specific DC subset that is involved in Th2 cell differentiation in vivo in response to a protease allergen, as well as infection with Nippostrongylus brasiliensis. We have demonstrated that this subset is controlled by the transcription factor interferon regulatory factor 4 (IRF4), which is required for their differentiation and Th2 cell-inducing function. IRF4 is known to control Th2 cell differentiation and Th2 cell-associated suppressing function in Treg cells. Our finding suggests that IRF4 also plays a role in DCs where it controls the initiation of Th2 cell responses.

journal_name

Immunity

journal_title

Immunity

authors

Gao Y,Nish SA,Jiang R,Hou L,Licona-Limón P,Weinstein JS,Zhao H,Medzhitov R

doi

10.1016/j.immuni.2013.08.028

subject

Has Abstract

pub_date

2013-10-17 00:00:00

pages

722-32

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(13)00380-4

journal_volume

39

pub_type

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