Treg cells and CTLA-4: the ball and chain of the germinal center response.

Abstract:

:The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center.

journal_name

Immunity

journal_title

Immunity

authors

Linterman MA,Denton AE

doi

10.1016/j.immuni.2014.12.009

subject

Has Abstract

pub_date

2014-12-18 00:00:00

pages

876-8

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(14)00451-8

journal_volume

41

pub_type

评论,杂志文章

相关文献

IMMUNITY文献大全
  • Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors.

    abstract::Monocytes are effectors of the inflammatory response to microbes. Human CD14(+) monocytes specialize in phagocytosis and production of reactive oxygen species and secrete inflammatory cytokines in response to a broad range of microbial cues. Here, we have characterized the functions of human monocytes that lack CD14 (...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2010.08.012

    authors: Cros J,Cagnard N,Woollard K,Patey N,Zhang SY,Senechal B,Puel A,Biswas SK,Moshous D,Picard C,Jais JP,D'Cruz D,Casanova JL,Trouillet C,Geissmann F

    更新日期:2010-09-24 00:00:00

  • Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection.

    abstract::Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteri...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2014.12.020

    authors: Blériot C,Dupuis T,Jouvion G,Eberl G,Disson O,Lecuit M

    更新日期:2015-01-20 00:00:00

  • Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.

    abstract::Recent evidence has suggested that signals other than those from Toll-like receptors (TLRs) could contribute to the elicitation of antigen-specific immunity. Therefore, we examined the role of the Nod-like receptor (NLR) family member, Nod1, in the generation of adaptive immune responses. Our findings show that innate...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2007.03.009

    authors: Fritz JH,Le Bourhis L,Sellge G,Magalhaes JG,Fsihi H,Kufer TA,Collins C,Viala J,Ferrero RL,Girardin SE,Philpott DJ

    更新日期:2007-04-01 00:00:00

  • Microglia Get a Little Help from "Th"-eir Friends.

    abstract::The presence of CD4+ T cells in the healthy brain parenchyma remains controversial due to the barrier function of the glia limitans. Pasciuto, Burton, Roca et al. in Cell describe the dynamic recruitment of CD4+ T cells within the brain parenchyma, their unexpected contribution to microglial maturation, and, ultimatel...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2020.08.011

    authors: Locatelli G,Engelhardt B

    更新日期:2020-09-15 00:00:00

  • The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality.

    abstract::The role of the center of the immunological synapse (the central supramolecular activation cluster or cSMAC) is controversial. One model suggests that the role of the cSMAC depends on antigen quality and can both enhance signaling and receptor downregulation, whereas a second model proposes that the sole function of t...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2008.06.014

    authors: Cemerski S,Das J,Giurisato E,Markiewicz MA,Allen PM,Chakraborty AK,Shaw AS

    更新日期:2008-09-19 00:00:00

  • Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

    abstract::Recognition of major histocompatibility class I molecules on target cells by natural killer (NK) cells confers selective protection from NK-mediated lysis. Cross-linking of the p58 NK receptor, involved in the recognition of HLA-C alleles, delivers a negative signal that prevents target cell lysis. Molecular cloning o...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(95)90025-x

    authors: Wagtmann N,Biassoni R,Cantoni C,Verdiani S,Malnati MS,Vitale M,Bottino C,Moretta L,Moretta A,Long EO

    更新日期:1995-05-01 00:00:00

  • Plasmacytoid Dendritic Cells: Development, Regulation, and Function.

    abstract::Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon. This review summarizes our current understanding of pDC biology, including transcriptional regulation, heterogeneity, role in antiviral ...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2018.12.027

    authors: Reizis B

    更新日期:2019-01-15 00:00:00

  • The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells.

    abstract::Interleukin-22 (IL-22) plays a critical role in mucosal defense, although the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood. We show that the CXCL16-CXCR6 chemokine-chemokine receptor axis regulated group 3 innate lymphoid cell (ILC3) diversity and function. CXCL16 was constitutiv...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2014.10.007

    authors: Satoh-Takayama N,Serafini N,Verrier T,Rekiki A,Renauld JC,Frankel G,Di Santo JP

    更新日期:2014-11-20 00:00:00

  • Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow.

    abstract::Aging results in increased myelopoiesis, which is linked to the increased incidence of myeloid leukemias and production of myeloid-derived suppressor cells. Here, we examined the contribution of plasma cells (PCs) to age-related increases in myelopoiesis, as PCs exhibit immune regulatory function and sequester in bone...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2019.06.006

    authors: Pioli PD,Casero D,Montecino-Rodriguez E,Morrison SL,Dorshkind K

    更新日期:2019-08-20 00:00:00

  • Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.

    abstract::Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genita...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2016.12.013

    authors: Gosmann C,Anahtar MN,Handley SA,Farcasanu M,Abu-Ali G,Bowman BA,Padavattan N,Desai C,Droit L,Moodley A,Dong M,Chen Y,Ismail N,Ndung'u T,Ghebremichael MS,Wesemann DR,Mitchell C,Dong KL,Huttenhower C,Walker BD,Virgi

    更新日期:2017-01-17 00:00:00

  • Dying to replicate: the orchestration of the viral life cycle, cell death pathways, and immunity.

    abstract::Manipulation of cell death pathways has been identified as a common feature of host-microbe interactions. We examine two examples: influenza A as a representative acute infection and cytomegalovirus as an example of chronic infection. From the perspective of viral entry, replication, and transmission, we identify poin...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2011.10.010

    authors: Yatim N,Albert ML

    更新日期:2011-10-28 00:00:00

  • "Dangerous crystals".

    abstract::Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2008.10.005

    authors: DeFranco AL

    更新日期:2008-11-14 00:00:00

  • The LTi cell, an immunologic chameleon.

    abstract::Lymphoid tissue inducer (LTi) cells are key components of the machinery required for the construction of the lymphoid structures underlying immune responses. In this issue of Immunity, Vonarbourg et. al. (2010) describe how these cells assume several different guises, each associated with different LTi functions. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2010.11.016

    authors: Strober W

    更新日期:2010-11-24 00:00:00

  • TRAF3: uncovering the real but restricted role in human.

    abstract::In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2010.09.008

    authors: Bowie AG

    更新日期:2010-09-24 00:00:00

  • Whole-body anatomy of human T cells.

    abstract::Knowledge of the regional tissue distribution of T cell subsets is a prerequisite for understanding protective immunity and the pathophysiology of T cell-mediated diseases. In this issue of Immunity, Sathaliyawala et al. (2012) present a comprehensive human tissue T cell analysis. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2013.01.006

    authors: Neuenhahn M,Busch DH

    更新日期:2013-01-24 00:00:00

  • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

    abstract::Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxi...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.08.004

    authors: Gehrke N,Mertens C,Zillinger T,Wenzel J,Bald T,Zahn S,Tüting T,Hartmann G,Barchet W

    更新日期:2013-09-19 00:00:00

  • Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.

    abstract::Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. We report that transient receptor potential melastatin-like 7 (TRPM7),...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2017.11.026

    authors: Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN

    更新日期:2018-01-16 00:00:00

  • Loss of CD47 Makes Dendritic Cells See Red.

    abstract::Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2015.09.008

    authors: van den Berg TK,van Bruggen R

    更新日期:2015-10-20 00:00:00

  • Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas.

    abstract::Tumors frequently subvert major histocompatibility complex class I (MHC-I) peptide presentation to evade CD8+ T cell immunosurveillance, though how this is accomplished is not always well defined. To identify the global regulatory networks controlling antigen presentation, we employed genome-wide screening in human di...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2020.11.002

    authors: Dersh D,Phelan JD,Gumina ME,Wang B,Arbuckle JH,Holly J,Kishton RJ,Markowitz TE,Seedhom MO,Fridlyand N,Wright GW,Huang DW,Ceribelli M,Thomas CJ,Lack JB,Restifo NP,Kristie TM,Staudt LM,Yewdell JW

    更新日期:2021-01-12 00:00:00

  • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

    abstract::We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the presence of TLR3, TLR4, or TLR9 stimuli. Treg can be substituted by TGFbeta1, which, together with the proinflammatory cytokine IL-6, sup...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2006.01.001

    authors: Veldhoen M,Hocking RJ,Atkins CJ,Locksley RM,Stockinger B

    更新日期:2006-02-01 00:00:00

  • The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

    abstract::The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that t...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2008.06.018

    authors: Hikosaka Y,Nitta T,Ohigashi I,Yano K,Ishimaru N,Hayashi Y,Matsumoto M,Matsuo K,Penninger JM,Takayanagi H,Yokota Y,Yamada H,Yoshikai Y,Inoue J,Akiyama T,Takahama Y

    更新日期:2008-09-19 00:00:00

  • NLRC3 puts the brakes on STING.

    abstract::NOD-like receptors (NLRs) are increasingly implicated in regulating pathogen-sensing pathways. In this issue of Immunity, Zhang et al. (2014) describe a role for NLRC3 in regulating STING and the inflammatory response to cytosolic DNA. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2014.02.007

    authors: Mangan MS,Latz E

    更新日期:2014-03-20 00:00:00

  • Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum.

    abstract::The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80064-3

    authors: Plebanski M,Flanagan KL,Lee EA,Reece WH,Hart K,Gelder C,Gillespie G,Pinder M,Hill AV

    更新日期:1999-06-01 00:00:00

  • Monomeric and oligomeric complexes of the B cell antigen receptor.

    abstract::The current structural model of the B cell antigen receptor (BCR) describes it as a symmetric protein complex in which one membrane-bound immunoglobulin molecule (mIg) is noncovalently bound on each side by an Ig-alpha/Ig-beta heterodimer. Using peptide-tagged Ig-alpha proteins, blue native polyacrylamide gel electrop...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)00003-0

    authors: Schamel WW,Reth M

    更新日期:2000-07-01 00:00:00

  • Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel.

    abstract::Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to bind need to be removed from the ER. Here we provide evidence that peptide export utilizes the Sec61p translocon as demonstrated by block...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)00013-3

    authors: Koopmann JO,Albring J,Hüter E,Bulbuc N,Spee P,Neefjes J,Hämmerling GJ,Momburg F

    更新日期:2000-07-01 00:00:00

  • A RHIM with a View: FLYing with Functional Amyloids.

    abstract::Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2017.10.001

    authors: Shin S,Cherry S

    更新日期:2017-10-17 00:00:00

  • Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.

    abstract::Secondary diversification of the B cell repertoire by immunoglobulin gene somatic hypermutation in the germinal center (GC) is essential for providing the high-affinity antibody specificities required for long-term humoral immunity. While the risk to self-tolerance posed by inadvertent generation of self-reactive GC B...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2012.07.017

    authors: Chan TD,Wood K,Hermes JR,Butt D,Jolly CJ,Basten A,Brink R

    更新日期:2012-11-16 00:00:00

  • Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

    abstract::Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retent...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00281-9

    authors: Brakebusch C,Fillatreau S,Potocnik AJ,Bungartz G,Wilhelm P,Svensson M,Kearney P,Körner H,Gray D,Fässler R

    更新日期:2002-03-01 00:00:00

  • The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.

    abstract::The peptidoglycan sensor Nod2 and the autophagy protein ATG16L1 have been linked to Crohn's disease (CD). Although Nod2 and the related sensor, Nod1, direct ATG16L1 to initiate anti-bacterial autophagy, whether ATG16L1 affects Nod-driven inflammation has not been examined. Here, we uncover an unanticipated autophagy-i...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.10.013

    authors: Sorbara MT,Ellison LK,Ramjeet M,Travassos LH,Jones NL,Girardin SE,Philpott DJ

    更新日期:2013-11-14 00:00:00

  • GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation.

    abstract::The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmu...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2019.03.022

    authors: Dougan M,Dranoff G,Dougan SK

    更新日期:2019-04-16 00:00:00