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Plasmacytoid Dendritic Cells: Development, Regulation, and Function.

Abstract：

:Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon. This review summarizes our current understanding of pDC biology, including transcriptional regulation, heterogeneity, role in antiviral immune responses, and involvement in immune pathology, particularly in autoimmune diseases, immunodeficiency, and cancer. We also highlight the remaining gaps in our knowledge and important questions for the field, such as the molecular basis of unique interferon-producing capacity of pDCs. A better understanding of cell type-specific positive and negative control of pDC function should pave the way for translational applications focused on this immune cell type.

journal_name

Immunity

journal_title

Immunity

authors

Reizis B

doi

10.1016/j.immuni.2018.12.027

subject

Has Abstract

pub_date

2019-01-15 00:00:00

pages

37-50

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(18)30575-2

journal_volume

50

pub_type

杂志文章,评审

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