Abstract:
:The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system. Here, we report that, in the nucleus of a T cell, a major fraction of Ikaros and Aiolos proteins associate with the DNA-dependent ATPase Mi-2 and histone deacetylases, in a 2 MD complex. This Ikaros-NURD complex is active in chromatin remodeling and histone deacetylation. Upon T cell activation, Ikaros recruits Mi-2/HDAC to regions of heterochromatin. These studies reveal that Ikaros proteins are capable of targeting chromatin remodeling and deacetylation complexes in vivo. We propose that the restructuring of chromatin is a key aspect of Ikaros function in lymphocyte differentiation.
journal_name
Immunityjournal_title
Immunityauthors
Kim J,Sif S,Jones B,Jackson A,Koipally J,Heller E,Winandy S,Viel A,Sawyer A,Ikeda T,Kingston R,Georgopoulos Kdoi
10.1016/s1074-7613(00)80034-5keywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
345-55issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80034-5journal_volume
10pub_type
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