Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease.

abstract：:B cells diversify and affinity mature their antigen receptor repertoire in germinal centers (GCs). GC B cells receive help signals during transient interaction with T cells, yet it remains unknown how these transient T-B interactions in the light zone sustain the subsequent proliferative program of selected B cells th...

journal_title：Immunity

authors： Chou C,Verbaro DJ,Tonc E,Holmgren M,Cella M,Colonna M,Bhattacharya D,Egawa T

更新日期：2016-09-20 00:00:00

abstract：:Vaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of responses, we analyzed the response to H7N9 vaccination in H7N9-naive adults. We performed comprehensive comparisons...

journal_title：Immunity

authors： Andrews SF,Chambers MJ,Schramm CA,Plyler J,Raab JE,Kanekiyo M,Gillespie RA,Ransier A,Darko S,Hu J,Chen X,Yassine HM,Boyington JC,Crank MC,Chen GL,Coates E,Mascola JR,Douek DC,Graham BS,Ledgerwood JE,McDermott AB

更新日期：2019-08-20 00:00:00

abstract：:Activation of the innate immune response in Metazoans is initiated through the recognition of microbes by host pattern-recognition receptors. In Drosophila, diaminopimelic acid (DAP)-containing peptidoglycan from Gram-negative bacteria is detected by the transmembrane receptor PGRP-LC and by the intracellular receptor...

journal_title：Immunity

authors： Iatsenko I,Kondo S,Mengin-Lecreulx D,Lemaitre B

更新日期：2016-11-15 00:00:00

abstract：:Autophagy constitutes a mechanism for the sequestration and lysosomal degradation of various cytoplasmic structures, including damaged organelles and invading microorganisms. Autophagy not only represents an essential cell-intrinsic mechanism to protect against internal and external stress conditions but also shapes c...

journal_title：Immunity

authors： Ma Y,Galluzzi L,Zitvogel L,Kroemer G

更新日期：2013-08-22 00:00:00

abstract：:Immunoglobulin A (IgA) is prominently secreted at mucosal surfaces and coats a fraction of the intestinal microbiota. However, the commensal bacteria bound by IgA are poorly characterized and the type of humoral immunity they elicit remains elusive. We used bacterial flow cytometry coupled with 16S rRNA gene sequencin...

journal_title：Immunity

authors： Bunker JJ,Flynn TM,Koval JC,Shaw DG,Meisel M,McDonald BD,Ishizuka IE,Dent AL,Wilson PC,Jabri B,Antonopoulos DA,Bendelac A

更新日期：2015-09-15 00:00:00

abstract：:Dendritic cells (DCs) are the antigen presenting cells that initiate and regulate immunity. By studying these cells in vivo, we will be able to move beyond standard approaches and design vaccines that directly harness the elaborate properties of DCs to control immunity. ...

journal_title：Immunity

authors： Steinman RM

更新日期：2008-09-19 00:00:00

abstract：:The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily protein BTLA regulated H...

journal_title：Immunity

authors： Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG

更新日期：2019-08-20 00:00:00

abstract：:The molecular basis of T cell anergy is not completely understood. We show that in antigen-primed anergic murine CD4(+) T cells the linker for activation of T cells (LAT) is hypophosphorylated upon CD3/CD28 restimulation. Signaling events downstream of LAT (PLCgamma1 phosphorylation and p85 [PI3-K] association) were i...

journal_title：Immunity

authors： Hundt M,Tabata H,Jeon MS,Hayashi K,Tanaka Y,Krishna R,De Giorgio L,Liu YC,Fukata M,Altman A

更新日期：2006-05-01 00:00:00

abstract：:In 2006, a clinical trial with the CD28 superagonistic antibody TGN1412 in London turned into a catastrophe. Studies are beginning to unravel the difference between the human and preclinical animal response to the antibody. ...

journal_title：Immunity

authors： Schraven B,Kalinke U

更新日期：2008-05-01 00:00:00

abstract：:We and others have defined a transcriptional silencer critical for the proper expression of the CD4 gene at all stages of T cell development. In this report, we use biochemical techniques to identify three different factor-binding sites within the CD4 silencer, denoted sites I, II, and III. Using transgenic analyses, ...

journal_title：Immunity

authors： Duncan DD,Adlam M,Siu G

更新日期：1996-03-01 00:00:00

abstract：:To explain why solid cancers grow or are rejected, we examined how the tumor stroma affected the level of antigen expression necessary to induce an immune response. We applied a tamoxifen-regulated Cre-loxP system to induce a model SIYRYYGL antigen recognized by the 2C T cell receptor. Solid tumors expressing the anti...

journal_title：Immunity

authors： Spiotto MT,Yu P,Rowley DA,Nishimura MI,Meredith SC,Gajewski TF,Fu YX,Schreiber H

更新日期：2002-12-01 00:00:00

abstract：:Peptide-specific down-regulation of T cell responses may represent a powerful tool to intervene in autoimmune diseases or graft rejections. It is therefore important to know whether peptide treatment tolerizes both naive and antigen-experienced memory T lymphocytes. Here we show that a major histocompatibility complex...

journal_title：Immunity

authors： Aichele P,Brduscha-Riem K,Oehen S,Odermatt B,Zinkernagel RM,Hengartner H,Pircher H

更新日期：1997-05-01 00:00:00

abstract：:The Foxp3+ T cell lineage is thought to arise from self-specific precursors during development. By using a unique mouse model, Pacholczyk et al. (2007) present compelling evidence that self-specific cells are exceedingly rare among Foxp3(-) and, surprisingly, Foxp3+ subsets. ...

journal_title：Immunity

authors： Stephens GL,Shevach EM

更新日期：2007-09-01 00:00:00

abstract：:Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes. R...

journal_title：Immunity

authors： Rosser EC,Mauri C

更新日期：2015-04-21 00:00:00

abstract：:In this issue of Immunity, Duprez et al. (2011) demonstrate that necroptosis, a form of regulated necrosis that is mediated by the kinases RIPK1 and RIPK3, underlies the lethal effects of tumor necrosis factor in vivo. ...

journal_title：Immunity

authors： Galluzzi L,Kroemer G

更新日期：2011-12-23 00:00:00

abstract：:Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) ...

journal_title：Immunity

authors： Mueller YM,De Rosa SC,Hutton JA,Witek J,Roederer M,Altman JD,Katsikis PD

更新日期：2001-12-01 00:00:00

abstract：:MicroRNA (miRNA)-deficient helper T cells exhibit abnormal IFN-γ production and decreased proliferation. However, the contributions of individual miRNAs to this phenotype remain poorly understood. We conducted a screen for miRNA function in primary T cells and identified individual miRNAs that rescue the defects assoc...

journal_title：Immunity

authors： Steiner DF,Thomas MF,Hu JK,Yang Z,Babiarz JE,Allen CD,Matloubian M,Blelloch R,Ansel KM

更新日期：2011-08-26 00:00:00

abstract：:Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...

journal_title：Immunity

authors： Agudo J,Brown BD

更新日期：2016-03-15 00:00:00

abstract：:Janus kinases are critical for cytokine signaling. Mutations of Jak3 cause primary immunodeficiency, but Minegishi et al. (2006) now show that mutation of another Jak, tyrosine kinase 2, underlies another human immunodeficiency syndrome. ...

journal_title：Immunity

authors： Watford WT,O'Shea JJ

更新日期：2006-11-01 00:00:00

abstract：:Aryl hydrocarbon receptor (Ahr) is crucial for the maintenance and function of group 3 innate lymphoid cells (ILCs), which are important in gut immunity. Because Ahr promotes T helper 17 (Th17) cell differentiation in vitro, it is reasonable to expect that Ahr would enhance Th17 cells in vivo. Instead, we show that Ah...

journal_title：Immunity

authors： Qiu J,Guo X,Chen ZM,He L,Sonnenberg GF,Artis D,Fu YX,Zhou L

更新日期：2013-08-22 00:00:00

abstract：:Previous in vitro studies defined the minimal regions of RAG1 and RAG2 essential for V(D)J recombination. In order to characterize the role of the C-terminal "dispensable" portion of RAG2, we generated core-RAG2 knock-in mice. We found that the core-RAG2-containing recombinase complex is selectively defective in catal...

journal_title：Immunity

authors： Liang HE,Hsu LY,Cado D,Cowell LG,Kelsoe G,Schlissel MS

更新日期：2002-11-01 00:00:00

abstract：:What causes slow wound healing rates in diabetes is poorly understood. Wong et al. (2015) report that an increase in the deployment of neutrophil extracellular traps associated with hyperglycemia slows down wound healing. ...

journal_title：Immunity

authors： Papayannopoulos V

更新日期：2015-08-18 00:00:00

abstract：:Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effec...

journal_title：Immunity

authors： Ohneda O,Ohneda K,Nomiyama H,Zheng Z,Gold SA,Arai F,Miyamoto T,Taillon BE,McIndoe RA,Shimkets RA,Lewin DA,Suda T,Lasky LA

更新日期：2000-02-01 00:00:00

abstract：:CD4(+) T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to antigen-presenting B cells but not dendritic cells (DCs), resulting in defective germinal center formation. However, the nature of this selective adhesion defect remained u...

journal_title：Immunity

authors： Cannons JL,Qi H,Lu KT,Dutta M,Gomez-Rodriguez J,Cheng J,Wakeland EK,Germain RN,Schwartzberg PL

更新日期：2010-02-26 00:00:00

abstract：:Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light chain chain gene loci form functional immunoglobulin genes during B cell development. In mouse bone marrow the differential surface expression of B220 (CD45R), c-kit, CD25, and surrogate light chain as well as the cell cycle status ...

journal_title：Immunity

authors： Grawunder U,Leu TM,Schatz DG,Werner A,Rolink AG,Melchers F,Winkler TH

更新日期：1995-11-01 00:00:00

abstract：:We previously reported that the mice deficient for SPA-1, a Rap1 GTPase-activating protein, developed hematopoietic stem cell disorders. Here, we demonstrate that SPA-1(-/-) mice show an age-dependent increase in B220(high) B1a cells producing anti-dsDNA antibody and lupus-like nephritis. SPA-1(-/-) peritoneal B1 cell...

journal_title：Immunity

authors： Ishida D,Su L,Tamura A,Katayama Y,Kawai Y,Wang SF,Taniwaki M,Hamazaki Y,Hattori M,Minato N

更新日期：2006-04-01 00:00:00

abstract：:Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necro...

journal_title：Immunity

authors： Del Fresno C,Sancho D

更新日期：2020-01-14 00:00:00

abstract：:Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection. ...

journal_title：Immunity

authors： Beura LK,Masopust D

更新日期：2015-03-17 00:00:00

abstract：:Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high-affinity antibodies and memory B cells. Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma ...

journal_title：Immunity

authors： Crotty S

更新日期：2014-10-16 00:00:00

abstract：:Checkpoint-blocking antibodies can generate potent anti-tumor responses by encouraging the immune system to seek and destroy cancer cells. At this time, the United States Food and Drug Administration has approved three checkpoint-blocking antibodies in three disease indications, and additional approvals are expected t...

journal_title：Immunity

authors： Callahan MK,Postow MA,Wolchok JD

更新日期：2016-05-17 00:00:00