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MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells.

Abstract：

:MicroRNA (miRNA)-deficient helper T cells exhibit abnormal IFN-γ production and decreased proliferation. However, the contributions of individual miRNAs to this phenotype remain poorly understood. We conducted a screen for miRNA function in primary T cells and identified individual miRNAs that rescue the defects associated with miRNA deficiency. Multiple members of the miR-17 and miR-92 families enhanced miRNA-deficient T cell proliferation whereas miR-29 largely corrected their aberrant interferon-γ (IFN-γ) expression. Repression of IFN-γ production by miR-29 involved direct targeting of both T-bet and Eomes, two transcription factors known to induce IFN-γ production. Although not usually expressed at functionally relevant amounts in helper T cells, Eomes was abundant in miRNA-deficient cells and was upregulated after miR-29 inhibition in wild-type cells. These results demonstrate that miR-29 regulates helper T cell differentiation by repressing multiple target genes, including at least two that are independently capable of inducing the T helper 1 (Th1) cell gene expression program.

journal_name

Immunity

journal_title

Immunity

authors

Steiner DF,Thomas MF,Hu JK,Yang Z,Babiarz JE,Allen CD,Matloubian M,Blelloch R,Ansel KM

doi

10.1016/j.immuni.2011.07.009

subject

Has Abstract

pub_date

2011-08-26 00:00:00

pages

169-81

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(11)00300-1

journal_volume

35

pub_type

杂志文章

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