A Shocking Type of Communication.


:In allergic patients, small amounts of allergen activate mast cells and trigger an immune cascade that can result in anaphylactic shock. In a recent issue of Science, Choi et al. (2018) show that dendritic cells sample the lumen of blood vessels and use microvesicles to trigger mast cell degranulation and anaphylaxis.






Sallis BF,Fiebiger E




Has Abstract


2018-12-18 00:00:00
















  • CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.

    abstract::The participation of a specific subset of B cells and how they are regulated in cancer is unclear. Here, we demonstrate that the proportion of CD5(+) relative to interleukin-6 receptor α (IL-6Rα)-expressing B cells was greatly increased in tumors. CD5(+) B cells responded to IL-6 in the absence of IL-6Rα. IL-6 directl...


    pub_type: 杂志文章


    authors: Zhang C,Xin H,Zhang W,Yazaki PJ,Zhang Z,Le K,Li W,Lee H,Kwak L,Forman S,Jove R,Yu H

    更新日期:2016-04-19 00:00:00

  • MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function.

    abstract::Vgamma2Vdelta2 T cells comprise 2%-5% of human peripheral blood T cells, recognize ubiquitous nonpeptide antigens, and expand up to 50-fold during microbial infection. It is not clear why these Vgamma2Vdelta2 T cells expand only after microbial infection. We show here that the stress-inducible molecule, MICA, is induc...


    pub_type: 杂志文章


    authors: Das H,Groh V,Kuijl C,Sugita M,Morita CT,Spies T,Bukowski JF

    更新日期:2001-07-01 00:00:00

  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency.

    abstract::Tristetraprolin (TTP) is a widely expressed potential transcription factor that contains two unusual CCCH zinc fingers and is encoded by the immediate-early response gene, Zfp-36. Mice made deficient in TTP by gene targeting appeared normal at birth, but soon manifested marked medullary and extramedullary myeloid hype...


    pub_type: 杂志文章


    authors: Taylor GA,Carballo E,Lee DM,Lai WS,Thompson MJ,Patel DD,Schenkman DI,Gilkeson GS,Broxmeyer HE,Haynes BF,Blackshear PJ

    更新日期:1996-05-01 00:00:00

  • microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.

    abstract::microRNA-155 (miR-155) is expressed by cells of the immune system after activation and has been shown to be required for antibody production after vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymus-dependent and -independent antigens. B cells lackin...


    pub_type: 杂志文章


    authors: Vigorito E,Perks KL,Abreu-Goodger C,Bunting S,Xiang Z,Kohlhaas S,Das PP,Miska EA,Rodriguez A,Bradley A,Smith KG,Rada C,Enright AJ,Toellner KM,Maclennan IC,Turner M

    更新日期:2007-12-01 00:00:00

  • CD28 superagonists: what makes the difference in humans?

    abstract::In 2006, a clinical trial with the CD28 superagonistic antibody TGN1412 in London turned into a catastrophe. Studies are beginning to unravel the difference between the human and preclinical animal response to the antibody. ...


    pub_type: 杂志文章


    authors: Schraven B,Kalinke U

    更新日期:2008-05-01 00:00:00

  • Treg cells and CTLA-4: the ball and chain of the germinal center response.

    abstract::The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center. ...


    pub_type: 评论,杂志文章


    authors: Linterman MA,Denton AE

    更新日期:2014-12-18 00:00:00

  • Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.

    abstract::Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced N...


    pub_type: 杂志文章


    authors: Laky K,Evans S,Perez-Diez A,Fowlkes BJ

    更新日期:2015-01-20 00:00:00

  • Antisocial networking in T helper cells.

    abstract::T helper cell differentiation is controlled by a network of transcription factors. In this issue of Immunity, Yagi et al. (2010) describe the opposing effects of transcription factors Runx3 and GATA3 in the network promoting T helper 1 cell development. ...


    pub_type: 评论,杂志文章


    authors: Pham D,Kaplan MH

    更新日期:2010-04-23 00:00:00

  • Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis.

    abstract::The tolerogenic microenvironment of the liver is associated with impaired hepatic T cell function. Here, we examined the contribution of liver-resident natural killer (LrNK) cells, a prominent hepatic NK cell compartment, to T cell antiviral responses in the liver. The number of virus-specific T cells increased in LrN...


    pub_type: 杂志文章


    authors: Zhou J,Peng H,Li K,Qu K,Wang B,Wu Y,Ye L,Dong Z,Wei H,Sun R,Tian Z

    更新日期:2019-02-19 00:00:00

  • A molecular basis for NKT cell recognition of CD1d-self-antigen.

    abstract::The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted microbial and self-lipid antigens, although the molecular basis of self-CD1d recognition is unclear. Here, we have characterized NKT TCR recognition of CD1d molecules loaded with natural self-antigens (Ags) and report the 2.3 Å resolution ...


    pub_type: 杂志文章


    authors: Mallevaey T,Clarke AJ,Scott-Browne JP,Young MH,Roisman LC,Pellicci DG,Patel O,Vivian JP,Matsuda JL,McCluskey J,Godfrey DI,Marrack P,Rossjohn J,Gapin L

    更新日期:2011-03-25 00:00:00

  • The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

    abstract::The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficiency rescued the embryonic lethality caused by loss of Caspase-8 or FAD...


    pub_type: 杂志文章


    authors: Alvarez-Diaz S,Dillon CP,Lalaoui N,Tanzer MC,Rodriguez DA,Lin A,Lebois M,Hakem R,Josefsson EC,O'Reilly LA,Silke J,Alexander WS,Green DR,Strasser A

    更新日期:2016-09-20 00:00:00

  • Why aging T cells fail: implications for vaccination.

    abstract::The decline in CD4+ T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly. ...


    pub_type: 杂志文章,评审


    authors: Haynes L,Swain SL

    更新日期:2006-06-01 00:00:00

  • Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

    abstract::The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regu...


    pub_type: 杂志文章


    authors: Sitnicka E,Bryder D,Theilgaard-Mönch K,Buza-Vidas N,Adolfsson J,Jacobsen SE

    更新日期:2002-10-01 00:00:00

  • Functional characterization of a novel hematopoietic stem cell and its place in the c-Kit maturation pathway in bone marrow cell development.

    abstract::While the majority of purified pluripotential hematopoietic stem cells (PHSC) express c-Kit, the receptor for steel factor, we have phenotypically and functionally separated a distinct class of PHSC that does not express c-Kit. In contrast to c-Kit-positive (c-Kit(pos)) PHSC, the c-Kit-negative (c-Kit(neg)) PHSC do no...


    pub_type: 杂志文章


    authors: Ortiz M,Wine JW,Lohrey N,Ruscetti FW,Spence SE,Keller JR

    更新日期:1999-02-01 00:00:00

  • Transcriptional Networks Driving Dendritic Cell Differentiation and Function.

    abstract::Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of pathogens to stimulate a robust and appropriate immune response. To initiate responses to highly disparate challenges, DCs have diversified into multiple phenotypically, anatomically, and functionally distinct cell types. As a res...


    pub_type: 杂志文章,评审


    authors: Nutt SL,Chopin M

    更新日期:2020-06-16 00:00:00

  • NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

    abstract::Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1). Here we found that the nucleotide-binding, leucine-rich-repeat-containing protein, NLRC3, reduced STING-dependent innate immune...


    pub_type: 杂志文章


    authors: Zhang L,Mo J,Swanson KV,Wen H,Petrucelli A,Gregory SM,Zhang Z,Schneider M,Jiang Y,Fitzgerald KA,Ouyang S,Liu ZJ,Damania B,Shu HB,Duncan JA,Ting JP

    更新日期:2014-03-20 00:00:00

  • HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH.

    abstract::HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical MHC II molecules in acidic compartments. During this association DM is supposed to catalyze the release of invariant chain (Ii)-derived CLIP peptides, as well as other peptides bound with low kinetic stability. Here we provide evidence t...


    pub_type: 杂志文章


    authors: Kropshofer H,Arndt SO,Moldenhauer G,Hämmerling GJ,Vogt AB

    更新日期:1997-03-01 00:00:00

  • Germinal Center B Cell Dynamics.

    abstract::Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of aff...


    pub_type: 杂志文章,评审


    authors: Mesin L,Ersching J,Victora GD

    更新日期:2016-09-20 00:00:00

  • The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.

    abstract::Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate parasite expulsion but also contribute to airway inflammation, emphasizing the functional similarity between these cells and Th2 cells. C...


    pub_type: 杂志文章


    authors: Mjösberg J,Bernink J,Golebski K,Karrich JJ,Peters CP,Blom B,te Velde AA,Fokkens WJ,van Drunen CM,Spits H

    更新日期:2012-10-19 00:00:00

  • Scratching Beyond the Surface of Itchy Wounds.

    abstract::In this issue of Immunity, Xu et al. reveal that dermal dendritic cells produce interleukin-31, which acts on neurons to promote wound itch. Their findings link itch associated with deeper wounds-wounds that extend beyond the epithelium-to the cells and cytokines that mediate wound healing. ...


    pub_type: 杂志文章


    authors: Yang TB,Kim BS

    更新日期:2020-08-18 00:00:00

  • Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis.

    abstract::PKCβ-null (Prkcb-/-) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization. Moreover, these mice failed to develop plasma cells in response to viral inf...


    pub_type: 杂志文章


    authors: Tsui C,Martinez-Martin N,Gaya M,Maldonado P,Llorian M,Legrave NM,Rossi M,MacRae JI,Cameron AJ,Parker PJ,Leitges M,Bruckbauer A,Batista FD

    更新日期:2018-06-19 00:00:00

  • Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

    abstract::The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system. Here, we report that, in the nucleus of a T cell, a major fraction of Ikaros and Aiolos proteins associate with the DNA-dependent ATPase Mi-2 and histone deacetylases...


    pub_type: 杂志文章


    authors: Kim J,Sif S,Jones B,Jackson A,Koipally J,Heller E,Winandy S,Viel A,Sawyer A,Ikeda T,Kingston R,Georgopoulos K

    更新日期:1999-03-01 00:00:00

  • SHIP modulates immune receptor responses by regulating membrane association of Btk.

    abstract::Membrane recruitment of SHIP is responsible for the inhibitory signal generated by FcgammaRIIB coligation to the BCR. By reducing the level of PIP3, SHIP regulates the association of the tyrosine kinase Btk with the membrane through PH domain-phosphoinositol lipid interactions. Inhibition of BCR signaling by either Fc...


    pub_type: 杂志文章


    authors: Bolland S,Pearse RN,Kurosaki T,Ravetch JV

    更新日期:1998-04-01 00:00:00

  • Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

    abstract::Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series of Zap70 variants with step-wise decreases ...


    pub_type: 杂志文章


    authors: Siggs OM,Miosge LA,Yates AL,Kucharska EM,Sheahan D,Brdicka T,Weiss A,Liston A,Goodnow CC

    更新日期:2007-12-01 00:00:00

  • Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis.

    abstract::Fibrosis is an incurable disorder of unknown etiology. Segregated-nucleus-containing atypical monocytes (SatMs) are critical for the development of fibrosis. Here we examined the mechanisms that recruit SatMs to pre-fibrotic areas. A screen based on cytokine expression in the fibrotic lung revealed that the chemokine ...


    pub_type: 杂志文章


    authors: Fukushima K,Satoh T,Sugihara F,Sato Y,Okamoto T,Mitsui Y,Yoshio S,Li S,Nojima S,Motooka D,Nakamura S,Kida H,Standley DM,Morii E,Kanto T,Yanagita M,Matsuura Y,Nagasawa T,Kumanogoh A,Akira S

    更新日期:2020-03-17 00:00:00

  • A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter.

    abstract::Human cytomegalovirus inhibits peptide import into the endoplasmic reticulum (ER) by the MHC-encoded TAP peptide transporter. We identified the open reading frame US6 to mediate this effect. Expression of the 21 kDa US6 glycoprotein in human cytomegalovirus-infected cells correlates with the inhibition of peptide tran...


    pub_type: 杂志文章


    authors: Hengel H,Koopmann JO,Flohr T,Muranyi W,Goulmy E,Hämmerling GJ,Koszinowski UH,Momburg F

    更新日期:1997-05-01 00:00:00

  • Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation.

    abstract::Antibody responses develop following SARS-CoV-2 infection, but little is known about their epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein spike (S) from a COVID-19-infected subject 21 days after the onset ...


    pub_type: 杂志文章


    authors: Seydoux E,Homad LJ,MacCamy AJ,Parks KR,Hurlburt NK,Jennewein MF,Akins NR,Stuart AB,Wan YH,Feng J,Whaley RE,Singh S,Boeckh M,Cohen KW,McElrath MJ,Englund JA,Chu HY,Pancera M,McGuire AT,Stamatatos L

    更新日期:2020-07-14 00:00:00

  • The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.

    abstract::The Bcl-2-associated X protein (Bax) and Bcl-2-antagonist/killer (Bak) are essential regulators of lymphocyte apoptosis, but whether they play a role in viable T cell function remains unclear. Here, we report that T cells lacking both Bax and Bak display defects in antigen-specific proliferation because of Ca(2+)-sign...


    pub_type: 杂志文章


    authors: Jones RG,Bui T,White C,Madesh M,Krawczyk CM,Lindsten T,Hawkins BJ,Kubek S,Frauwirth KA,Wang YL,Conway SJ,Roderick HL,Bootman MD,Shen H,Foskett JK,Thompson CB

    更新日期:2007-08-01 00:00:00

  • Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.

    abstract::Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. We have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of erythrocyte invasi...


    pub_type: 临床试验,杂志文章


    authors: Boyle MJ,Reiling L,Feng G,Langer C,Osier FH,Aspeling-Jones H,Cheng YS,Stubbs J,Tetteh KK,Conway DJ,McCarthy JS,Muller I,Marsh K,Anders RF,Beeson JG

    更新日期:2015-03-17 00:00:00

  • The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

    abstract::The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that t...


    pub_type: 杂志文章


    authors: Hikosaka Y,Nitta T,Ohigashi I,Yano K,Ishimaru N,Hayashi Y,Matsumoto M,Matsuo K,Penninger JM,Takayanagi H,Yokota Y,Yamada H,Yoshikai Y,Inoue J,Akiyama T,Takahama Y

    更新日期:2008-09-19 00:00:00