Abstract：
:A major mechanism maintaining immune tolerance is the deletion of potentially autoreactive thymocytes by apoptosis during development in the thymus. Previous reports suggest that apoptosis is induced by high avidity signals transduced via the T cell receptor; however, the role of signals transduced by other cell surface receptors during thymic selection remains poorly understood. Fas, a member of the TNF receptor family, has been shown to induce apoptosis in mature peripheral T cells; however, the effects of Fas on negative selection of thymocytes have not been previously detected. Using a sensitive terminal deoxynucleotidyl transferase method to detect apoptotic cells, we found that mutant Fas molecules in lpr mice decrease the sensitivity of thymocytes to T cell receptor-mediated apoptosis and that blockade of Fas-Fas ligand interactions in vivo can inhibit antigen-induced apoptosis of thymocytes in non-lpr mice. Thus, we have shown that Fas, in conjunction with antigen-specific signals, can modulate apoptosis during negative selection of thymocytes.
journal_name
Immunityjournal_title
Immunityauthors
Castro JE,Listman JA,Jacobson BA,Wang Y,Lopez PA,Ju S,Finn PW,Perkins DLdoi
10.1016/s1074-7613(00)80275-7subject
Has Abstractpub_date
1996-12-01 00:00:00pages
617-27issue
6eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80275-7journal_volume
5pub_type
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