Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors.

abstract：:Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of aff...

journal_title：Immunity

authors： Mesin L,Ersching J,Victora GD

更新日期：2016-09-20 00:00:00

abstract：:Inflammation mediated by antibody-antigen complexes contributes to autoimmune diseases. Mice deficient in the common Fcgamma-chain are protected from IgG-mediated glomerulonephritis and the reverse passive Arthus (RPA) reaction and FcR-bearing macrophages, and mast cells have been assigned primary roles in these proce...

journal_title：Immunity

authors： Tsuboi N,Asano K,Lauterbach M,Mayadas TN

更新日期：2008-06-01 00:00:00

abstract：:Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...

journal_title：Immunity

authors： Wang Y,Bi Y,Chen X,Li C,Li Y,Zhang Z,Wang J,Lu Y,Yu Q,Su H,Yang H,Liu G

更新日期：2016-06-21 00:00:00

abstract：:Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively regulates all cell types involved in the initiation, propagation, and resolution of inflammation. Here, we focus on Jak-Stat signaling in three major cell types involved in inflammatory responses: T cells, neutrophils, and macrop...

journal_title：Immunity

authors： O'Shea JJ,Murray PJ

更新日期：2008-04-01 00:00:00

abstract：:Three mutant immunoglobulin heavy chain (IgH) insertion mice were generated in which a targeted nonfunctional IgH passenger transgene was either devoid of promoter (pdelta) or was placed under the transcriptional control of either its own RNA polymerase II-dependent IgH promoter (pII) or a RNA polymerase I-dependent p...

journal_title：Immunity

authors： Fukita Y,Jacobs H,Rajewsky K

更新日期：1998-07-01 00:00:00

abstract：:Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxi...

journal_title：Immunity

authors： Gehrke N,Mertens C,Zillinger T,Wenzel J,Bald T,Zahn S,Tüting T,Hartmann G,Barchet W

更新日期：2013-09-19 00:00:00

abstract：:Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits pro...

journal_title：Immunity

authors： Zhang X,Sun S,Hwang I,Tough DF,Sprent J

更新日期：1998-05-01 00:00:00

abstract：:What does it take to make a regulatory T (Treg) cell? In this issue of Immunity, Ohkura et al. show that Treg-cell-specific CpG hypomethylation and Foxp3 expression are independent events required for Treg cell development, stability, and full suppressive activity. ...

journal_title：Immunity

authors： Delgoffe GM,Bettini ML,Vignali DA

更新日期：2012-11-16 00:00:00

abstract：:The development, validation, and appropriate application of serological assays to detect antibodies to SARS-CoV-2 are essential to determining seroprevalence of this virus in the United States and globally and in guiding government leadership and the private sector on back-to-work policies. An interagency working grou...

journal_title：Immunity

authors： Lerner AM,Eisinger RW,Lowy DR,Petersen LR,Humes R,Hepburn M,Cassetti MC

更新日期：2020-07-14 00:00:00

abstract：:Using a transgenic approach, we examined distal regulatory elements located in the IL-4 locus and the role of GATA-3 at these elements. The intergenic DNase I hypersensitive sites (HSS) showed strong enhancement, and the intronic enhancer (IE) and HS5/HS5a sites showed weaker enhancement of the IL-4 promoter. Elements...

journal_title：Immunity

authors： Lee GR,Fields PE,Flavell RA

更新日期：2001-04-01 00:00:00

abstract：:Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light chain chain gene loci form functional immunoglobulin genes during B cell development. In mouse bone marrow the differential surface expression of B220 (CD45R), c-kit, CD25, and surrogate light chain as well as the cell cycle status ...

journal_title：Immunity

authors： Grawunder U,Leu TM,Schatz DG,Werner A,Rolink AG,Melchers F,Winkler TH

更新日期：1995-11-01 00:00:00

abstract：:The identification of specific genetic loci that contribute to inflammatory and autoimmune diseases has proved difficult due to the contribution of multiple interacting genes, the inherent genetic heterogeneity present in human populations, and a lack of new mouse mutants. By using N-ethyl-N-nitrosourea (ENU) mutagene...

journal_title：Immunity

authors： Yu P,Constien R,Dear N,Katan M,Hanke P,Bunney TD,Kunder S,Quintanilla-Martinez L,Huffstadt U,Schröder A,Jones NP,Peters T,Fuchs H,de Angelis MH,Nehls M,Grosse J,Wabnitz P,Meyer TP,Yasuda K,Schiemann M,Schneider-Fr

更新日期：2005-04-01 00:00:00

abstract：:During development, discrete cell fates often result from variation in the intensity of a particular signal. The mechanisms underlying these seemingly analog-to-digital switches are not understood. In developing T lymphocytes, low-intensity signals through the antigen receptor result in positive selection while more i...

journal_title：Immunity

authors： Neilson JR,Winslow MM,Hur EM,Crabtree GR

更新日期：2004-03-01 00:00:00

abstract：:The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regu...

journal_title：Immunity

authors： Sitnicka E,Bryder D,Theilgaard-Mönch K,Buza-Vidas N,Adolfsson J,Jacobsen SE

更新日期：2002-10-01 00:00:00

abstract：:mel-18 is a mammalian Polycomb group gene encoding a transcriptional repressor with tumor suppressive activity. Overexpression of mel-18 in mice results in cell cycle arrest of B cells upon B cell receptor stimulation with downregulation of c-myc. This phenotype is rescued in mel-18/c-myc double-transgenic mice, sugge...

journal_title：Immunity

authors： Tetsu O,Ishihara H,Kanno R,Kamiyasu M,Inoue H,Tokuhisa T,Taniguchi M,Kanno M

更新日期：1998-10-01 00:00:00

abstract：:A large and diverse array of chemoattractants control leukocyte trafficking, but how these apparently redundant signals collaborate in vivo is still largely unknown. We previously demonstrated an absolute requirement for the lipid chemoattractant leukotriene B(4) (LTB(4)) and its receptor BLT1 for neutrophil recruitme...

journal_title：Immunity

authors： Chou RC,Kim ND,Sadik CD,Seung E,Lan Y,Byrne MH,Haribabu B,Iwakura Y,Luster AD

更新日期：2010-08-27 00:00:00

abstract：:The transcription factor Blimp-1 regulates the overall accumulation of virus-specific CD8⁺ T cells during acute viral infections. We found that increased proliferation and survival of Blimp-1-deficient CD8⁺ T cells resulted from sustained expression of CD25 and CD27 and persistent cytokine responsiveness. Silencing of...

journal_title：Immunity

authors： Shin HM,Kapoor V,Guan T,Kaech SM,Welsh RM,Berg LJ

更新日期：2013-10-17 00:00:00

abstract：:Interleukin-2 (IL-2) and downstream transcription factor STAT5 are important for maintaining regulatory T (Treg) cell homeostasis and function. Treg cells can respond to low IL-2 levels, but the mechanisms of STAT5 activation during partial IL-2 deficiency remain uncertain. We identified the serine-threonine kinase Ms...

journal_title：Immunity

authors： Shi H,Liu C,Tan H,Li Y,Nguyen TM,Dhungana Y,Guy C,Vogel P,Neale G,Rankin S,Feng Y,Peng J,Tao W,Chi H

更新日期：2018-11-20 00:00:00

abstract：:Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. The TCR is rapidly internalized after antigen stimulation and then degraded in lysosomes. However, few of the molecules involved...

journal_title：Immunity

authors： Ouchida R,Yamasaki S,Hikida M,Masuda K,Kawamura K,Wada A,Mochizuki S,Tagawa M,Sakamoto A,Hatano M,Tokuhisa T,Koseki H,Saito T,Kurosaki T,Wang JY

更新日期：2008-07-18 00:00:00

abstract：:The current structural model of the B cell antigen receptor (BCR) describes it as a symmetric protein complex in which one membrane-bound immunoglobulin molecule (mIg) is noncovalently bound on each side by an Ig-alpha/Ig-beta heterodimer. Using peptide-tagged Ig-alpha proteins, blue native polyacrylamide gel electrop...

journal_title：Immunity

authors： Schamel WW,Reth M

更新日期：2000-07-01 00:00:00

abstract：:Dietary fiber protects against chronic inflammatory diseases by dampening immune responses through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in viral infection, where the anti-inflammatory properties of SCFAs in principle could prevent protective immunity. Instead, we found that fer...

journal_title：Immunity

authors： Trompette A,Gollwitzer ES,Pattaroni C,Lopez-Mejia IC,Riva E,Pernot J,Ubags N,Fajas L,Nicod LP,Marsland BJ

更新日期：2018-05-15 00:00:00

abstract：:Regulatory T cell-mediated dominant tolerance has been demonstrated to play an important role in the prevention of autoimmunity. Here, we present data arguing that the forkhead transcription factor Foxp3 acts as the regulatory T cell lineage specification factor and mediator of the genetic mechanism of dominant tolera...

journal_title：Immunity

authors： Fontenot JD,Rasmussen JP,Williams LM,Dooley JL,Farr AG,Rudensky AY

更新日期：2005-03-01 00:00:00

abstract：:The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that t...

journal_title：Immunity

authors： Hikosaka Y,Nitta T,Ohigashi I,Yano K,Ishimaru N,Hayashi Y,Matsumoto M,Matsuo K,Penninger JM,Takayanagi H,Yokota Y,Yamada H,Yoshikai Y,Inoue J,Akiyama T,Takahama Y

更新日期：2008-09-19 00:00:00

abstract：:Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to th...

journal_title：Immunity

authors： Suan D,Kräutler NJ,Maag JLV,Butt D,Bourne K,Hermes JR,Avery DT,Young C,Statham A,Elliott M,Dinger ME,Basten A,Tangye SG,Brink R

更新日期：2017-12-19 00:00:00

abstract：:Gallstone formation in adults is a common, yet incompletely understood disease process. In this issue, Muñoz et al. (2019) report a pathogenic link between neutrophil extracellular traps (NETs) and the formation of gallstones. ...

journal_title：Immunity

authors： O'Neil LJ,Kaplan MJ

更新日期：2019-09-17 00:00:00

abstract：:The contribution of MyD88 adaptor-mediated signaling in immune responses to fungi is largely unexplored. In this issue of Immunity, show that MyD88 is dispensable in several aspects of dendritic-cell trafficking and T cell differentiation in response to a respiratory fungus. ...

journal_title：Immunity

authors： van Lier RA,Lutter R

更新日期：2006-10-01 00:00:00

abstract：:A major mechanism maintaining immune tolerance is the deletion of potentially autoreactive thymocytes by apoptosis during development in the thymus. Previous reports suggest that apoptosis is induced by high avidity signals transduced via the T cell receptor; however, the role of signals transduced by other cell surfa...

journal_title：Immunity

authors： Castro JE,Listman JA,Jacobson BA,Wang Y,Lopez PA,Ju S,Finn PW,Perkins DL

更新日期：1996-12-01 00:00:00

abstract：:The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily protein BTLA regulated H...

journal_title：Immunity

authors： Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG

更新日期：2019-08-20 00:00:00

abstract：:It is unclear how an effective T cell repertoire is built from a limited array of T cell receptor (TCR) genes. In this issue of Immunity, Stadinski et al. (2011) demonstrate that TCR variable (V) α chains can indirectly affect Vβ-mediated recognition of the major histocompatibility complex (MHC) molecule. ...

journal_title：Immunity

authors： Turner SJ,Rossjohn J

更新日期：2011-11-23 00:00:00

abstract：:Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses. However, deregulated production and/or activation of these cytokines can lead to the development of multiple inflammatory disorders. IL-1 fam...

journal_title：Immunity

authors： Afonina IS,Müller C,Martin SJ,Beyaert R

更新日期：2015-06-16 00:00:00