Abstract：
:Aire promotes the tolerization of thymocytes by inducing the expression of a battery of peripheral-tissue antigens in thymic medullary epithelial cells. We demonstrate that the cellular mechanism by which Aire exerts its tolerance-promoting function is not primarily positive selection of regulatory T cells, but rather negative selection of T effector cells. Surprisingly, supplementing its influence on the transcription of genes encoding peripheral-tissue antigens, Aire somehow enhances the antigen-presentation capability of medullary epithelial cells. Thus, this transcriptional control element promotes central tolerance both by furnishing a specific thymic stromal cell type with a repertoire of self antigens and by better arming such cells to present these antigens to differentiating thymocytes. In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops.
journal_name
Immunityjournal_title
Immunityauthors
Anderson MS,Venanzi ES,Chen Z,Berzins SP,Benoist C,Mathis Ddoi
10.1016/j.immuni.2005.07.005keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
227-39issue
2eissn
1074-7613issn
1097-4180pii
S1074-7613(05)00237-2journal_volume
23pub_type
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