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The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

Abstract：

:The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition molecules mediate host immunity to various pathogenic stimuli. However, in vivo evidence for the involvement of NLR proteins in viral sensing has not been widely investigated and remains controversial. As a test of the physiologic role of the NLR molecule NLRP3 during RNA viral infection, we explored the in vivo role of NLRP3 inflammasome components during influenza virus infection. Mice lacking Nlrp3, Pycard, or caspase-1, but not Nlrc4, exhibited dramatically increased mortality and a reduced immune response after exposure to the influenza virus. Utilizing analogs of dsRNA (poly(I:C)) and ssRNA (ssRNA40), we demonstrated that an NLRP3-mediated response could be activated by RNA species. Mechanistically, NLRP3 inflammasome activation by the influenza virus was dependent on lysosomal maturation and reactive oxygen species (ROS). Inhibition of ROS induction eliminated IL-1beta production in animals during influenza infection. Together, these data place the NLRP3 inflammasome as an essential component in host defense against influenza infection through the sensing of viral RNA.

journal_name

Immunity

journal_title

Immunity

authors

Allen IC,Scull MA,Moore CB,Holl EK,McElvania-TeKippe E,Taxman DJ,Guthrie EH,Pickles RJ,Ting JP

doi

10.1016/j.immuni.2009.02.005

subject

Has Abstract

pub_date

2009-04-17 00:00:00

pages

556-65

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(09)00139-3

journal_volume

30

pub_type

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