One bug or another: promiscuous T cells form lifelong memory.

Abstract:

:As humans age, their T cell repertoire becomes dominated by cells exhibiting "memory" characteristics. In this issue of Immunity, Su et al. (2013) demonstrate that a large percentage of virus-specific CD4(+) T cells also exhibit a memory phenotype in unexposed adults.

journal_name

Immunity

journal_title

Immunity

authors

Nolz JC,Harty JT

doi

10.1016/j.immuni.2013.02.002

subject

Has Abstract

pub_date

2013-02-21 00:00:00

pages

207-8

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(13)00057-5

journal_volume

38

pub_type

评论,杂志文章

相关文献

IMMUNITY文献大全
  • Tec kinases in T cell development: a clue behind the mask?

    abstract::In this issue of Immunity, studies from Atherly et al (2006) and Broussard et al. (2006) show that mice deficient in Tec kinases support development of a population of CD8(+) T cells with "innate-immune" properties. The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmenta...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2006.07.006

    authors: Hogquist KA

    更新日期:2006-07-01 00:00:00

  • Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I.

    abstract::Vgamma9Vdelta2 T lymphocytes, a major gammadelta T lymphocyte subset in humans, display cytolytic activity against various tumor cells upon recognition of yet uncharacterized structures. Here, we show that an entity related to the mitochondrial F1-ATPase is expressed on tumor cell surface and promotes tumor recognitio...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2004.11.012

    authors: Scotet E,Martinez LO,Grant E,Barbaras R,Jenö P,Guiraud M,Monsarrat B,Saulquin X,Maillet S,Estève JP,Lopez F,Perret B,Collet X,Bonneville M,Champagne E

    更新日期:2005-01-01 00:00:00

  • Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.

    abstract::Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 signaling are unclear. We used a genetic knockin reporter system in mice to track and reciprocally delete or express IL-1 receptor 1 (IL-1R1) in specif...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.12.012

    authors: Liu X,Nemeth DP,McKim DB,Zhu L,DiSabato DJ,Berdysz O,Gorantla G,Oliver B,Witcher KG,Wang Y,Negray CE,Vegesna RS,Sheridan JF,Godbout JP,Robson MJ,Blakely RD,Popovich PG,Bilbo SD,Quan N

    更新日期:2019-02-19 00:00:00

  • Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs.

    abstract::CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(03)00116-x

    authors: Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

    更新日期:2003-05-01 00:00:00

  • Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential.

    abstract::Cognate interactions of naive T cells with antigen-presenting dendritic cells require physical cell-cell contacts leading to signal induction and T cell activation. Using a three-dimensional collagen matrix videomicroscopy model for ovalbumin peptide-specific activation of murine and oxidative mitogenesis of human T c...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)00032-7

    authors: Gunzer M,Schäfer A,Borgmann S,Grabbe S,Zänker KS,Bröcker EB,Kämpgen E,Friedl P

    更新日期:2000-09-01 00:00:00

  • Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis.

    abstract::Memory T cells provide long-lasting protective immunity, and distinct subpopulations of memory T cells drive chronic inflammatory diseases such as asthma. Asthma is a chronic allergic inflammatory disease with airway remodeling including fibrotic changes. The immunological mechanisms that induce airway fibrotic change...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.04.023

    authors: Morimoto Y,Hirahara K,Kiuchi M,Wada T,Ichikawa T,Kanno T,Okano M,Kokubo K,Onodera A,Sakurai D,Okamoto Y,Nakayama T

    更新日期:2018-07-17 00:00:00

  • Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL.

    abstract::Differentiation of memory cells involves DNA-sequence changes in B lymphocytes but is less clearly defined in T cells. RNA rearrangement is identified here as a key event in memory T cell differentiation by analysis of a mouse mutation that altered the proportions of naive and memory T cells and crippled the process o...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2008.11.004

    authors: Wu Z,Jia X,de la Cruz L,Su XC,Marzolf B,Troisch P,Zak D,Hamilton A,Whittle B,Yu D,Sheahan D,Bertram E,Aderem A,Otting G,Goodnow CC,Hoyne GF

    更新日期:2008-12-19 00:00:00

  • Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors.

    abstract::Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) gene class switch recombination (CSR), somatic hypermutation (SHM), and somatic hyperconversion. In general, high AID expression is found in mature B cells that are responding to antigens. However, AID expression and SHM have also been det...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2007.05.018

    authors: Han JH,Akira S,Calame K,Beutler B,Selsing E,Imanishi-Kari T

    更新日期:2007-07-01 00:00:00

  • The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.

    abstract::The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily protein BTLA regulated H...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2019.05.022

    authors: Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG

    更新日期:2019-08-20 00:00:00

  • Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer.

    abstract::Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosuppressive networks t...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2012.03.004

    authors: Rabinovich GA,Croci DO

    更新日期:2012-03-23 00:00:00

  • "Nuts and bolts" of disease tolerance.

    abstract::Disease tolerance describes the ability of an infected host to limit disease severity without negatively impacting the causative pathogen. Bessede et al. (2014) show that the aryl hydrocarbon receptor is an essential component of disease tolerance during bacterial infection in mice. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2014.07.011

    authors: Soares MP

    更新日期:2014-08-21 00:00:00

  • Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia.

    abstract::Colony stimulating factor-1 (Csf-1) receptor and its ligand Csf-1 control macrophage development, maintenance, and function. The development of both Langerhans cells (LCs) and microglia is highly dependent on Csf-1 receptor signaling but independent of Csf-1. Here we show that in both mice and humans, interleukin-34 (...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2012.11.001

    authors: Greter M,Lelios I,Pelczar P,Hoeffel G,Price J,Leboeuf M,Kündig TM,Frei K,Ginhoux F,Merad M,Becher B

    更新日期:2012-12-14 00:00:00

  • "Hands-on" regulation of B cell development by the transcription factor Pax5.

    abstract::The transcription factor Pax5 is a critical regulator of B lymphocyte commitment and identity. In this issue of Immunity, Schebesta et al. (2007) demonstrate how Pax5 activates 170 different genes involved in B cell signaling, adhesion, migration, and maturation. ...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2007.07.001

    authors: Hagman J,Lukin K

    更新日期:2007-07-01 00:00:00

  • AMPK helps T cells survive nutrient starvation.

    abstract::Reprogramming of cellular metabolism is crucial for T cells responding to environmental cues. Blagih et al. (2015) reveal that the kinase AMPK directs metabolic adaption of effector T cells upon nutrient limitation and contributes to immune responses in vivo. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2014.12.029

    authors: Yang K,Chi H

    更新日期:2015-01-20 00:00:00

  • Complement is a central mediator of radiotherapy-induced tumor-specific immunity and clinical response.

    abstract::Radiotherapy induces DNA damage and cell death, but recent data suggest that concomitant immune stimulation is an integral part of the therapeutic action of ionizing radiation. It is poorly understood how radiotherapy supports tumor-specific immunity. Here we report that radiotherapy induced tumor cell death and trans...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2015.03.009

    authors: Surace L,Lysenko V,Fontana AO,Cecconi V,Janssen H,Bicvic A,Okoniewski M,Pruschy M,Dummer R,Neefjes J,Knuth A,Gupta A,van den Broek M

    更新日期:2015-04-21 00:00:00

  • NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.

    abstract::The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, O...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2011.03.026

    authors: Allen IC,Moore CB,Schneider M,Lei Y,Davis BK,Scull MA,Gris D,Roney KE,Zimmermann AG,Bowzard JB,Ranjan P,Monroe KM,Pickles RJ,Sambhara S,Ting JP

    更新日期:2011-06-24 00:00:00

  • Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

    abstract::Recognition of major histocompatibility class I molecules on target cells by natural killer (NK) cells confers selective protection from NK-mediated lysis. Cross-linking of the p58 NK receptor, involved in the recognition of HLA-C alleles, delivers a negative signal that prevents target cell lysis. Molecular cloning o...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(95)90025-x

    authors: Wagtmann N,Biassoni R,Cantoni C,Verdiani S,Malnati MS,Vitale M,Bottino C,Moretta L,Moretta A,Long EO

    更新日期:1995-05-01 00:00:00

  • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

    abstract::Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of B7 molecules, since blocking B7 maintains T cells in ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80284-8

    authors: Perez VL,Van Parijs L,Biuckians A,Zheng XX,Strom TB,Abbas AK

    更新日期:1997-04-01 00:00:00

  • Inflammasomes: Threat-Assessment Organelles of the Innate Immune System.

    abstract::Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or downstream of inflammasome assembly, serving as the principal enzymes that control activities of these organelles. In this review, we discus...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2019.08.005

    authors: Evavold CL,Kagan JC

    更新日期:2019-10-15 00:00:00

  • Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses.

    abstract::Regulatory T cells (Treg cells) perform suppressive functions in disparate tissue environments and against many inflammatory insults, yet the tissue-enriched factor(s) that influence Treg cell phenotype and function remain largely unknown. We have shown a vital role for transforming growth factor-β (TGF-β) signals in ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2017.03.015

    authors: Konkel JE,Zhang D,Zanvit P,Chia C,Zangarle-Murray T,Jin W,Wang S,Chen W

    更新日期:2017-04-18 00:00:00

  • Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity.

    abstract::Apoptotic death of T lymphocytes is critical for shutdown of immune responses and hemopoietic cell homeostasis. Both death receptor (Fas) activation and mitochondrial apoptosis triggered by the BH3-only protein Bim have been implicated in the killing of antigen-stimulated T cells. We examined mice lacking the gene enc...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2007.12.017

    authors: Hughes PD,Belz GT,Fortner KA,Budd RC,Strasser A,Bouillet P

    更新日期:2008-02-01 00:00:00

  • Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

    abstract::The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deleti...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2004.10.014

    authors: Liston A,Lesage S,Gray DH,O'Reilly LA,Strasser A,Fahrer AM,Boyd RL,Wilson J,Baxter AG,Gallo EM,Crabtree GR,Peng K,Wilson SR,Goodnow CC

    更新日期:2004-12-01 00:00:00

  • Pathogen recognition: TLRs throw us a curve.

    abstract::Toll-like receptors (TLRs) are the archetypal pattern recognition receptors (PRRs) envisioned by as innate sensors of pathogen attack and host triggers of an adaptive immune response. Two recent papers (Choe et al., 2005; Bell et al., 2005) reveal the distinctive architecture of a TLR sensor domain and hint at how thi...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2005.09.008

    authors: Kirk P,Bazan JF

    更新日期:2005-10-01 00:00:00

  • A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.

    abstract::Many hematopoietic cell types express CD1d and are capable of presenting glycolipid antigens to invariant natural killer T cells (iNKT cells). However, the question of which cells are the principal presenters of glycolipid antigens in vivo remains controversial, and it has been suggested that this might vary depending...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2013.12.004

    authors: Arora P,Baena A,Yu KO,Saini NK,Kharkwal SS,Goldberg MF,Kunnath-Velayudhan S,Carreño LJ,Venkataswamy MM,Kim J,Lazar-Molnar E,Lauvau G,Chang YT,Liu Z,Bittman R,Al-Shamkhani A,Cox LR,Jervis PJ,Veerapen N,Besra GS,Por

    更新日期:2014-01-16 00:00:00

  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency.

    abstract::Tristetraprolin (TTP) is a widely expressed potential transcription factor that contains two unusual CCCH zinc fingers and is encoded by the immediate-early response gene, Zfp-36. Mice made deficient in TTP by gene targeting appeared normal at birth, but soon manifested marked medullary and extramedullary myeloid hype...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80411-2

    authors: Taylor GA,Carballo E,Lee DM,Lai WS,Thompson MJ,Patel DD,Schenkman DI,Gilkeson GS,Broxmeyer HE,Haynes BF,Blackshear PJ

    更新日期:1996-05-01 00:00:00

  • Caspases in Cell Death, Inflammation, and Disease.

    abstract::Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important advancements include the identification of addi...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2019.05.020

    authors: Van Opdenbosch N,Lamkanfi M

    更新日期:2019-06-18 00:00:00

  • Notch 1 signaling regulates peripheral T cell activation.

    abstract::Notch signaling has been identified as an important regulator of leukocyte differentiation and thymic maturation. Less is known about the role of Notch signaling in regulating mature T cells. We examined the role of Notch 1 in regulating peripheral T cell activity in vitro and in vivo. Coligation of Notch 1 together w...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(04)00081-0

    authors: Eagar TN,Tang Q,Wolfe M,He Y,Pear WS,Bluestone JA

    更新日期:2004-04-01 00:00:00

  • Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.

    abstract::To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantia...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(94)90010-8

    authors: Chen J,Stewart V,Spyrou G,Hilberg F,Wagner EF,Alt FW

    更新日期:1994-04-01 00:00:00

  • ReaDAPting the Role of PGRP-SD in Bacterial Sensing and Immune Activation.

    abstract::Contradictory to previous reports, Iatsenko et al. (2016) reveal that PGRP-SD regulates the Imd signaling pathway rather than the Toll pathway in Drosophila and shed light on a decade-old mystery of conflicting structural and phenotypic data. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2016.11.002

    authors: Monahan A,Kleino A,Silverman N

    更新日期:2016-11-15 00:00:00

  • Nature's TRAIL--on a path to cancer immunotherapy.

    abstract::The TNF-related apoptosis-inducing ligand (TRAIL) offers great promise as a cancer therapeutic. Initially, soluble recombinant versions of the TRAIL molecule have exhibited specific tumoricidal activity against a variety of tumors alone, or in combination with other cancer treatments, and much anticipation awaits the ...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/s1074-7613(02)00502-2

    authors: Smyth MJ,Takeda K,Hayakawa Y,Peschon JJ,van den Brink MR,Yagita H

    更新日期:2003-01-01 00:00:00