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Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.

Abstract：

:Dietary fiber protects against chronic inflammatory diseases by dampening immune responses through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in viral infection, where the anti-inflammatory properties of SCFAs in principle could prevent protective immunity. Instead, we found that fermentable dietary fiber increased survival of influenza-infected mice through two complementary mechanisms. High-fiber diet (HFD)-fed mice exhibited altered bone marrow hematopoiesis, characterized by enhanced generation of Ly6c- patrolling monocytes, which led to increased numbers of alternatively activated macrophages with a limited capacity to produce the chemokine CXCL1 in the airways. Blunted CXCL1 production reduced neutrophil recruitment to the airways, thus limiting tissue immunopathology during infection. In parallel, diet-derived SCFAs boosted CD8+ T cell effector function by enhancing cellular metabolism. Hence, dietary fermentable fiber and SCFAs set an immune equilibrium, balancing innate and adaptive immunity so as to promote the resolution of influenza infection while preventing immune-associated pathology.

journal_name

Immunity

journal_title

Immunity

authors

Trompette A,Gollwitzer ES,Pattaroni C,Lopez-Mejia IC,Riva E,Pernot J,Ubags N,Fajas L,Nicod LP,Marsland BJ

doi

10.1016/j.immuni.2018.04.022

subject

Has Abstract

pub_date

2018-05-15 00:00:00

pages

992-1005.e8

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(18)30191-2

journal_volume

48

pub_type

杂志文章

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