Abstract：
:The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear. Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly image and establish the functional and molecular properties of embryonic thymopoiesis-initiating progenitors (T-IPs) before their entry into the thymus and activation of Notch signaling. T-IPs did not include multipotent stem cells or molecular evidence of T cell-restricted progenitors. Instead, single-cell molecular and functional analysis demonstrated that most fetal T-IPs expressed genes of and had the potential to develop into lymphoid as well as myeloid components of the immune system. Moreover, studies of embryos deficient in the transcriptional regulator RBPJ demonstrated that canonical Notch signaling was not involved in pre-thymic restriction to the T cell lineage or the migration of T-IPs.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Luis TC,Luc S,Mizukami T,Boukarabila H,Thongjuea S,Woll PS,Azzoni E,Giustacchini A,Lutteropp M,Bouriez-Jones T,Vaidya H,Mead AJ,Atkinson D,Böiers C,Carrelha J,Macaulay IC,Patient R,Geissmann F,Nerlov C,Sandberg R,doi
10.1038/ni.3576subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1424-1435issue
12eissn
1529-2908issn
1529-2916journal_volume
17pub_type
杂志文章abstract：:After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putati...
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pub_type： 已发布勘误
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