Abstract:
:The transcription factor BATF directly regulates key components of the formation and function of follicular helper T cells and antibody class switching in B cells.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Ellyard JI,Vinuesa CGdoi
10.1038/ni.2042subject
Has Abstractpub_date
2011-06-01 00:00:00pages
519-20issue
6eissn
1529-2908issn
1529-2916pii
ni.2042journal_volume
12pub_type
评论,新闻abstract::Diverse cellular responses to external cues are controlled by a small number of signal-transduction pathways, but how the specificity of functional outcomes is achieved remains unclear. Here we describe a mechanism for signal integration based on the functional coupling of two distinct signaling pathways widely used i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2845
更新日期:2014-04-01 00:00:00
abstract::After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putati...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2536
更新日期:2013-04-01 00:00:00
abstract::The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs). However, the metabolic requirements that support this process remain poorly defined. We found that DC glycolytic flux increased within minutes of exposure to TLR agonists and that this served an essential role in supporting ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2833
更新日期:2014-04-01 00:00:00
abstract::Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define alternative activation states. We found that RBP-J, the main nuclear transducer of signaling via Notch receptors, augmented Toll-like receptor 4 (TLR4)-induced expression of key mediators of classic...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2304
更新日期:2012-05-20 00:00:00
abstract::The lineage commitment of CD4+ T cells is coordinately regulated by signals through the T cell receptor and cytokine receptors, yet how these signals are integrated remains elusive. Here we find that mice lacking Dock2, a Rac activator in lymphocytes, developed allergic disease through a mechanism dependent on CD4+ T ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1506
更新日期:2007-10-01 00:00:00
abstract::Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population resp...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3078
更新日期:2015-02-01 00:00:00
abstract::T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy. E3 ligases are involved in maintaining the anergic state. However, the specific molecules responsible for the induction of anergy have yet to be elucidated. Using microarray analysis we have identified here early growth respo...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1193
更新日期:2005-05-01 00:00:00
abstract::Allergic inflammation has crucial roles in allergic diseases such as asthma. It is therefore important to understand why and how the immune system responds to allergens. Here we found that full-length interleukin 33 (IL-33FL), an alarmin cytokine with critical roles in type 2 immunity and asthma, functioned as a prote...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0067-5
更新日期:2018-04-01 00:00:00
abstract::All complexes of T cell receptors (TCRs) bound to peptide-major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1502
更新日期:2007-09-01 00:00:00
abstract::The mouse protein Qa-1 (HLA-E in humans) is essential for immunological protection and immune regulation. Although Qa-1 has been linked to CD8 T cell-dependent suppression, the physiological relevance of this observation is unclear. We generated mice deficient in Qa-1 to develop an understanding of this process. Qa-1-...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1063
更新日期:2004-05-01 00:00:00
abstract::Regulated glycosylation controls T cell processes, including activation, differentiation and homing by creating or masking ligands for endogenous lectins. Here we show that stimuli promoting T helper type 1 (TH1), TH2 or interleukin 17-producing T helper (TH-17) differentiation can differentially regulate the glycosyl...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1482
更新日期:2007-08-01 00:00:00
abstract::Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threa...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-00826-9
更新日期:2021-01-01 00:00:00
abstract::STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occurs. Although STING ER exit is the rate-limiting step in STING signal...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0730-5
更新日期:2020-08-01 00:00:00
abstract::Membrane recruitment of adaptor proteins is crucial for coupling antigen receptors to downstream signaling events. Despite the essential function of the B cell adaptor SLP-65, the mechanism of its recruitment to the plasma membrane is not yet understood. Here we show that a highly conserved leucine zipper in the SLP-6...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1163
更新日期:2005-02-01 00:00:00
abstract::Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a pa...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1814
更新日期:2009-12-01 00:00:00
abstract::Tyrosine kinases couple the T cell receptor (TCR) to discrete signaling cascades, each of which is capable of inducing a distinct functional outcome. Precisely how TCR signals are channeled toward specific targets remains unclear. TCR stimulation triggers 'alternative' activation of the mitogen-activated protein kinas...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1422
更新日期:2007-02-01 00:00:00
abstract::The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyloid A1 (SAA1), tha...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0698-1
更新日期:2020-07-01 00:00:00
abstract::The signaling pathways that regulate B and T lymphocytes are remarkably conserved between humans and mice. However, recent evidence suggests that the pathways regulating natural killer (NK) cell activation may actually differ between these two species. We discuss the controversies in the field and propose that this di...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni0902-807
更新日期:2002-09-01 00:00:00
abstract:: ...
journal_title:Nature immunology
pub_type: 评论,杂志文章
doi:10.1038/s41590-018-0240-x
更新日期:2018-11-01 00:00:00
abstract::The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte assembles a unique VLR by rearrangement of the germline gene. In the lamprey genome, we identify here about 850 distinct cassettes encoding leucine-ri...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1463
更新日期:2007-06-01 00:00:00
abstract::Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) appears to be specialized to produce peptides presented on class I major histocompatibility complex molecules. We found that purified ERAP1 trimmed peptides that were ten residues or longer, but spared eight-residue peptides. In vivo, ERAP1 enhanced production of an ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni860
更新日期:2002-12-01 00:00:00
abstract::T cell activation involves the orchestration of several signaling pathways, including that of the 'classical' transcription factor NF-kappaB components NF-kappaB1-RelA. The function of the 'nonclassical' NF-kappaB2-RelB pathway is less clear, although T cells lacking components of this pathway have activation defects....
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1351
更新日期:2006-07-01 00:00:00
abstract::The mechanisms that initiate T helper type 2 (T(H)2) responses are poorly understood. Here we demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus ant...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1883
更新日期:2010-07-01 00:00:00
abstract::In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured the attention of immunologists and clinicians due to their abundance in humans, their involvement in a broad range of infectious and non-infectious diseases and their unusual specificity for ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/s41590-019-0444-8
更新日期:2019-09-01 00:00:00
abstract::After homing to lymph nodes, CD8+ T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinet...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1559
更新日期:2008-03-01 00:00:00
abstract::Using a human CD25 reporter transgene controlled by regulatory sequences from the gene encoding pre-T cell receptor alpha, we identified a common lymphocyte precursor (CLP-2) population that, in contrast to the previously identified CLP-1 population, was c-Kit-B220+. In short-term culture, the CLP-2 could be derived f...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni965
更新日期:2003-09-01 00:00:00
abstract::The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell b...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/76877
更新日期:2000-07-01 00:00:00
abstract::Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestra...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.1937
更新日期:2010-10-01 00:00:00
abstract::As a result of decades of research-driven breakthroughs in basic and clinical science and recent advances in the broad-scale implementation of interventions for the prevention and treatment of infection with HIV, a turning point has been reached in the global HIV-AIDS pandemic. To end the pandemic and achieve the goal...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2735
更新日期:2013-11-01 00:00:00
abstract::The family of mammalian Nod-like receptors (NLRs) consists of critical intracellular immune proteins structurally related to plant resistance proteins. The NLRs NALP3 and IPAF, for example, can each form a multiprotein proinflammatory complex called the 'inflammasome', and mutations in the gene encoding Nod2, another ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1459
更新日期:2007-05-01 00:00:00