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Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.

Abstract：

:After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8+ effector cells. Long-lived memory CD8+ cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8+ effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8+ T cell immunity.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Best JA,Blair DA,Knell J,Yang E,Mayya V,Doedens A,Dustin ML,Goldrath AW,Immunological Genome Project Consortium.

doi

10.1038/ni.2536

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

404-12

issue

4

eissn

1529-2908

issn

1529-2916

pii

ni.2536

journal_volume

14

pub_type

杂志文章

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