Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels.

abstract：:Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it see...

journal_title：Nature immunology

authors： Ben-Neriah Y,Karin M

更新日期：2011-07-19 00:00:00

abstract：:The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found that activation of STAT5 worked together with defects in signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in BLNK,...

journal_title：Nature immunology

authors： Katerndahl CDS,Heltemes-Harris LM,Willette MJL,Henzler CM,Frietze S,Yang R,Schjerven H,Silverstein KAT,Ramsey LB,Hubbard G,Wells AD,Kuiper RP,Scheijen B,van Leeuwen FN,Müschen M,Kornblau SM,Farrar MA

更新日期：2017-06-01 00:00:00

abstract：:According to current models of hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)Flt3(hi)) and common myeloid progenitors (CMPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage-commitment pathways from hematopoietic stem cells, wi...

journal_title：Nature immunology

authors： Drissen R,Buza-Vidas N,Woll P,Thongjuea S,Gambardella A,Giustacchini A,Mancini E,Zriwil A,Lutteropp M,Grover A,Mead A,Sitnicka E,Jacobsen SEW,Nerlov C

更新日期：2016-06-01 00:00:00

abstract：:CD11b(+) dendritic cells (DCs) seem to be specialized for presenting antigens via major histocompatibility (MHC) class II complexes to stimulate helper T cells, but the genetic and regulatory basis for this is not established. Conditional deletion of Irf4 resulted in loss of CD11b(+) DCs, impaired formation of peptide...

journal_title：Nature immunology

authors： Vander Lugt B,Khan AA,Hackney JA,Agrawal S,Lesch J,Zhou M,Lee WP,Park S,Xu M,DeVoss J,Spooner CJ,Chalouni C,Delamarre L,Mellman I,Singh H

更新日期：2014-02-01 00:00:00

abstract：:Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cel...

journal_title：Nature immunology

authors： Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL,Immunological Genome Project Consortium.

更新日期：2012-10-01 00:00:00

abstract：:Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice...

journal_title：Nature immunology

authors： Mohrs M,Blankespoor CM,Wang ZE,Loots GG,Afzal V,Hadeiba H,Shinkai K,Rubin EM,Locksley RM

更新日期：2001-09-01 00:00:00

abstract：:The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+...

journal_title：Nature immunology

authors： Aliberti J,Reis e Sousa C,Schito M,Hieny S,Wells T,Huffnagle GB,Sher A

更新日期：2000-07-01 00:00:00

abstract：:As a result of decades of research-driven breakthroughs in basic and clinical science and recent advances in the broad-scale implementation of interventions for the prevention and treatment of infection with HIV, a turning point has been reached in the global HIV-AIDS pandemic. To end the pandemic and achieve the goal...

journal_title：Nature immunology

authors： Fauci AS,Folkers GK,Dieffenbach CW

更新日期：2013-11-01 00:00:00

abstract：:The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived fro...

journal_title：Nature immunology

authors： Miller MS,Rialdi A,Ho JS,Tilove M,Martinez-Gil L,Moshkina NP,Peralta Z,Noel J,Melegari C,Maestre AM,Mitsopoulos P,Madrenas J,Heinz S,Benner C,Young JA,Feagins AR,Basler CF,Fernandez-Sesma A,Becherel OJ,Lavin MF,va

更新日期：2015-05-01 00:00:00

abstract：:NLRX1 is unique among the nucleotide-binding-domain and leucine-rich-repeat (NLR) proteins in its mitochondrial localization and ability to negatively regulate antiviral innate immunity dependent on the adaptors MAVS and STING. However, some studies have suggested a positive regulatory role for NLRX1 in inducing antiv...

journal_title：Nature immunology

authors： Feng H,Lenarcic EM,Yamane D,Wauthier E,Mo J,Guo H,McGivern DR,González-López O,Misumi I,Reid LM,Whitmire JK,Ting JP,Duncan JA,Moorman NJ,Lemon SM

更新日期：2017-12-01 00:00:00

abstract：:Tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein (TRADD) is essential in recruiting signaling molecules to the TNFR1 receptor complex. Interferon-gamma (IFN-gamma) is a potent activator of macrophages and uses signal transducer and activator of transcription 1-alpha (STAT1-alpha) for signal tra...

journal_title：Nature immunology

authors： Wesemann DR,Qin H,Kokorina N,Benveniste EN

更新日期：2004-02-01 00:00:00

abstract：:The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process. ...

journal_title：Nature immunology

authors： Brown GD

更新日期：2008-10-01 00:00:00

abstract：:The signaling pathways that regulate B and T lymphocytes are remarkably conserved between humans and mice. However, recent evidence suggests that the pathways regulating natural killer (NK) cell activation may actually differ between these two species. We discuss the controversies in the field and propose that this di...

journal_title：Nature immunology

authors： Colucci F,Di Santo JP,Leibson PJ

更新日期：2002-09-01 00:00:00

abstract：:The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic insufficiency can imprint permanent T cell dysfunction. We found that TILs accumulated depolarized mitochondria as a res...

journal_title：Nature immunology

authors： Yu YR,Imrichova H,Wang H,Chao T,Xiao Z,Gao M,Rincon-Restrepo M,Franco F,Genolet R,Cheng WC,Jandus C,Coukos G,Jiang YF,Locasale JW,Zippelius A,Liu PS,Tang L,Bock C,Vannini N,Ho PC

更新日期：2020-12-01 00:00:00

abstract：:All complexes of T cell receptors (TCRs) bound to peptide-major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here ...

journal_title：Nature immunology

authors： Feng D,Bond CJ,Ely LK,Maynard J,Garcia KC

更新日期：2007-09-01 00:00:00

abstract：:The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...

journal_title：Nature immunology

authors： Soares L,Seroogy C,Skrenta H,Anandasabapathy N,Lovelace P,Chung CD,Engleman E,Fathman CG

更新日期：2004-01-01 00:00:00

abstract：:Regulated glycosylation controls T cell processes, including activation, differentiation and homing by creating or masking ligands for endogenous lectins. Here we show that stimuli promoting T helper type 1 (TH1), TH2 or interleukin 17-producing T helper (TH-17) differentiation can differentially regulate the glycosyl...

journal_title：Nature immunology

authors： Toscano MA,Bianco GA,Ilarregui JM,Croci DO,Correale J,Hernandez JD,Zwirner NW,Poirier F,Riley EM,Baum LG,Rabinovich GA

更新日期：2007-08-01 00:00:00

abstract：:EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (TH1) cell-mediated autoimmune disease, it can also be induced by TH2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is as...

journal_title：Nature immunology

authors： Pedotti R,Mitchell D,Wedemeyer J,Karpuj M,Chabas D,Hattab EM,Tsai M,Galli SJ,Steinman L

更新日期：2001-03-01 00:00:00

abstract：:CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. We used mice that were transgenic for one of two human CD46 isoforms that differ in their cytoplasmic domains (termed CD46-1 and CD46-2) to analyze the effect of CD46 stimulation ...

journal_title：Nature immunology

authors： Marie JC,Astier AL,Rivailler P,Rabourdin-Combe C,Wild TF,Horvat B

更新日期：2002-07-01 00:00:00

abstract：:CD160, a glycosylphosphatidylinositol-anchored member of the immunoglobulin superfamily, is expressed on both cytolytic lymphocytes and some unstimulated CD4+ T cells. Here we show that CD160 expression was increased after activation of human CD4+ T cells and that crosslinking CD160 with monoclonal antibody strongly i...

journal_title：Nature immunology

authors： Cai G,Anumanthan A,Brown JA,Greenfield EA,Zhu B,Freeman GJ

更新日期：2008-02-01 00:00:00

abstract：:The lineage commitment of CD4+ T cells is coordinately regulated by signals through the T cell receptor and cytokine receptors, yet how these signals are integrated remains elusive. Here we find that mice lacking Dock2, a Rac activator in lymphocytes, developed allergic disease through a mechanism dependent on CD4+ T ...

journal_title：Nature immunology

authors： Tanaka Y,Hamano S,Gotoh K,Murata Y,Kunisaki Y,Nishikimi A,Takii R,Kawaguchi M,Inayoshi A,Masuko S,Himeno K,Sasazuki T,Fukui Y

更新日期：2007-10-01 00:00:00

abstract：:Myelin basic protein-specific CD8(+) T cells can induce central nervous system autoimmunity; however, immune tolerance prevents these autoreactive cells from causing disease. To define the mechanisms that mediate tolerance, we developed two T cell receptor-transgenic mouse lines with different affinities for the H-2K(...

journal_title：Nature immunology

authors： Perchellet A,Stromnes I,Pang JM,Goverman J

更新日期：2004-06-01 00:00:00

abstract：:Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved unders...

journal_title：Nature immunology

authors： Kanneganti TD,Dixit VD

更新日期：2012-07-19 00:00:00

abstract：:High-dose radiation activates caspases in tumor cells to produce abundant DNA fragments for DNA sensing in antigen-presenting cells, but the intrinsic DNA sensing in tumor cells after radiation is rather limited. Here we demonstrate that irradiated tumor cells hijack caspase 9 signaling to suppress intrinsic DNA sensi...

journal_title：Nature immunology

authors： Han C,Liu Z,Zhang Y,Shen A,Dong C,Zhang A,Moore C,Ren Z,Lu C,Cao X,Zhang CL,Qiao J,Fu YX

更新日期：2020-05-01 00:00:00

abstract：:Nonmuscle myosin light-chain kinase (MYLK) mediates increased lung vascular endothelial permeability in lipopolysaccharide-induced lung inflammatory injury, the chief cause of the acute respiratory distress syndrome. In a lung injury model, we demonstrate here that MYLK was also essential for neutrophil transmigration...

journal_title：Nature immunology

authors： Xu J,Gao XP,Ramchandran R,Zhao YY,Vogel SM,Malik AB

更新日期：2008-08-01 00:00:00

abstract：:Autoreactive B cells have critical roles in a large diversity of autoimmune diseases, but the molecular pathways that control these cells remain poorly understood. We performed an in vivo functional screen of a lymphocyte-expressed microRNA library and identified miR-148a as a potent regulator of B cell tolerance. Ele...

journal_title：Nature immunology

authors： Gonzalez-Martin A,Adams BD,Lai M,Shepherd J,Salvador-Bernaldez M,Salvador JM,Lu J,Nemazee D,Xiao C

更新日期：2016-04-01 00:00:00

abstract：:Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-complex adaptor, binds and stabilizes mRNAs encoding key inflammatory proteins. The Act1 SEFIR domain binds a stem-loop structure, the SEFIR-bind...

journal_title：Nature immunology

authors： Herjan T,Hong L,Bubenik J,Bulek K,Qian W,Liu C,Li X,Chen X,Yang H,Ouyang S,Zhou H,Zhao J,Vasu K,Cockman E,Aronica M,Asosingh K,Licatalosi DD,Qin J,Fox PL,Hamilton TA,Driscoll D,Li X

更新日期：2018-04-01 00:00:00

abstract：:It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and pro...

journal_title：Nature immunology

authors： Migueles SA,Laborico AC,Shupert WL,Sabbaghian MS,Rabin R,Hallahan CW,Van Baarle D,Kostense S,Miedema F,McLaughlin M,Ehler L,Metcalf J,Liu S,Connors M

更新日期：2002-11-01 00:00:00

abstract：:In the steady state, dendritic cells (DCs) in the lymph node induce T cell tolerance to self antigens. Innate signals trigger the maturation of tissue DCs, which migrate into lymph nodes and activate T cells. To examine DCs in vivo, we produced transgenic mice whose DCs expressed enhanced yellow fluorescent protein. T...

journal_title：Nature immunology

authors： Lindquist RL,Shakhar G,Dudziak D,Wardemann H,Eisenreich T,Dustin ML,Nussenzweig MC

更新日期：2004-12-01 00:00:00

abstract：:Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear. Here, we show that the transcription fact...

journal_title：Nature immunology

authors： Gioulbasani M,Galaras A,Grammenoudi S,Moulos P,Dent AL,Sigvardsson M,Hatzis P,Kee BL,Verykokakis M

更新日期：2020-09-01 00:00:00