Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(-/-) mice.

Abstract:

:Mice deficient for paired immunoglobulin (Ig)-like receptor B (PIR-B) show defective regulation of receptor-mediated activation in antigen-presenting cells. Older PIR-B(-/-) mice had an increased number of peritoneal B1 cells. Splenic PIR-B(-/-) B2 cells were constitutively activated and proliferated much more than those from wild-type mice upon B cell receptor ligation. T helper type 2 (T(H)2)-prone humoral responses were augmented in PIR-B(-/-) mice upon immunization with T-dependent antigens, including increased interleukin 4 and decreased interferon-gamma responses, as well as enhanced IgG1 and IgE production. Impaired maturation of dendritic cells (DCs), possibly due to perturbed intracellular signaling, was responsible for the skewed responses. Thus, PIR-B is critical for B cell suppression, DC maturation and for balancing T(H)1 and T(H)2 immune responses.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Ujike A,Takeda K,Nakamura A,Ebihara S,Akiyama K,Takai T

doi

10.1038/ni801

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

542-8

issue

6

eissn

1529-2908

issn

1529-2916

pii

ni801

journal_volume

3

pub_type

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