Abstract：
:Invariant natural killer T cells (iNKT cells) can produce copious amounts of interleukin 4 (IL-4) early during infection. However, indirect evidence suggests they may produce this immunomodulatory cytokine in the steady state. Through intracellular staining for transcription factors, we have defined three subsets of iNKT cells (NKT1, NKT2 and NKT17) that produced distinct cytokines; these represented diverse lineages and not developmental stages, as previously thought. These subsets exhibited substantial interstrain variation in numbers. In several mouse strains, including BALB/c, NKT2 cells were abundant and were stimulated by self ligands to produce IL-4. In those strains, steady-state IL-4 conditioned CD8(+) T cells to become 'memory-like', increased serum concentrations of immunoglobulin E (IgE) and caused dendritic cells to produce chemokines. Thus, iNKT cell-derived IL-4 altered immunological properties under normal steady-state conditions.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Lee YJ,Holzapfel KL,Zhu J,Jameson SC,Hogquist KAdoi
10.1038/ni.2731subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1146-54issue
11eissn
1529-2908issn
1529-2916pii
ni.2731journal_volume
14pub_type
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