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The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.

Abstract：

:Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcription factor ATF7 in innate immunological memory. ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages by recruiting the histone H3K9 dimethyltransferase G9a. Treatment with lipopolysaccharide, which mimics bacterial infection, induced phosphorylation of ATF7 via the kinase p38, which led to the release of ATF7 from chromatin and a decrease in repressive histone H3K9me2 marks. A partially disrupted chromatin structure and increased basal expression of target genes were maintained for long periods, which enhanced resistance to pathogens. ATF7 might therefore be important in controlling memory in cells of the innate immune system.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Yoshida K,Maekawa T,Zhu Y,Renard-Guillet C,Chatton B,Inoue K,Uchiyama T,Ishibashi K,Yamada T,Ohno N,Shirahige K,Okada-Hatakeyama M,Ishii S

doi

10.1038/ni.3257

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

1034-43

issue

10

eissn

1529-2908

issn

1529-2916

pii

ni.3257

journal_volume

16

pub_type

杂志文章

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