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Critical functions for c-Myb at three checkpoints during thymocyte development.

Abstract：

:The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we identify three points at which c-Myb activity is required for normal T cell differentiation: transition through the double-negative 3 stage, survival of preselection CD4(+)CD8(+) thymocytes, and differentiation of CD4 thymocytes. Thus, c-Myb is essential at several stages during T cell development in the thymus.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Bender TP,Kremer CS,Kraus M,Buch T,Rajewsky K

doi

10.1038/ni1085

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

721-9

issue

7

eissn

1529-2908

issn

1529-2916

pii

ni1085

journal_volume

5

pub_type

杂志文章

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