Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

abstract：:Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778(G) of the gene encoding atypical chemokine receptor 1 (ACKR1). This polymorphism selectively abolishes the expression of ACKR1 in erythroid cells, causing a Duffy-negative phenotype. Here we describe an unexpected ...

journal_title：Nature immunology

authors： Duchene J,Novitzky-Basso I,Thiriot A,Casanova-Acebes M,Bianchini M,Etheridge SL,Hub E,Nitz K,Artinger K,Eller K,Caamaño J,Rülicke T,Moss P,Megens RTA,von Andrian UH,Hidalgo A,Weber C,Rot A

更新日期：2017-07-01 00:00:00

abstract：:Phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN) phosphatase serve essential functions in the regulation of cell growth, differentiation and survival by modulating intracellular phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) concentrations. Here we show that the conditional deletion o...

journal_title：Nature immunology

authors： Anzelon AN,Wu H,Rickert RC

更新日期：2003-03-01 00:00:00

abstract：:Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define alternative activation states. We found that RBP-J, the main nuclear transducer of signaling via Notch receptors, augmented Toll-like receptor 4 (TLR4)-induced expression of key mediators of classic...

journal_title：Nature immunology

authors： Xu H,Zhu J,Smith S,Foldi J,Zhao B,Chung AY,Outtz H,Kitajewski J,Shi C,Weber S,Saftig P,Li Y,Ozato K,Blobel CP,Ivashkiv LB,Hu X

更新日期：2012-05-20 00:00:00

abstract：:Feedback regulatory circuits provided by regulatory T cells (T(reg) cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of path...

journal_title：Nature immunology

authors： Banchereau J,Pascual V,O'Garra A

更新日期：2012-10-01 00:00:00

abstract：:Interleukin 17 (IL-17)-producing T helper 17 cells (T(H)-17 cells) have been described as a T helper cell subset distinct from T helper type 1 (T(H)1) and T(H)2 cells, with specific functions in antimicrobial defense and autoimmunity. The factors driving human T(H)-17 differentiation remain controversial. Using a syst...

journal_title：Nature immunology

authors： Volpe E,Servant N,Zollinger R,Bogiatzi SI,Hupé P,Barillot E,Soumelis V

更新日期：2008-06-01 00:00:00

abstract：:We describe a protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. CXCL16 contains a transmembrane domain and both membrane-bound and soluble forms are produced. Naïve CD8 T cells, natural killer T cells...

journal_title：Nature immunology

authors： Matloubian M,David A,Engel S,Ryan JE,Cyster JG

更新日期：2000-10-01 00:00:00

abstract：:The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...

journal_title：Nature immunology

authors： Soares L,Seroogy C,Skrenta H,Anandasabapathy N,Lovelace P,Chung CD,Engleman E,Fathman CG

更新日期：2004-01-01 00:00:00

abstract：:The mechanisms that initiate T helper type 2 (T(H)2) responses are poorly understood. Here we demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus ant...

journal_title：Nature immunology

authors： Tang H,Cao W,Kasturi SP,Ravindran R,Nakaya HI,Kundu K,Murthy N,Kepler TB,Malissen B,Pulendran B

更新日期：2010-07-01 00:00:00

abstract：:Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation. However, it is not known why CD4(+) T cells undergo less-efficient homeostatic proliferation than CD8(+) T cells do. Here we show that systemic IL-7 concentrations increased during ly...

journal_title：Nature immunology

authors： Guimond M,Veenstra RG,Grindler DJ,Zhang H,Cui Y,Murphy RD,Kim SY,Na R,Hennighausen L,Kurtulus S,Erman B,Matzinger P,Merchant MS,Mackall CL

更新日期：2009-02-01 00:00:00

abstract：:TBK1 is essential for interferon-β (IFN-β) production and innate antiviral immunity. Here we identified the T cell anergy-related E3 ubiquitin ligase RNF128 as a positive regulator of TBK1 activation. RNF128 directly interacted with TBK1 through its protease-associated (PA) domain and catalyzed the K63-linked polyubiq...

journal_title：Nature immunology

authors： Song G,Liu B,Li Z,Wu H,Wang P,Zhao K,Jiang G,Zhang L,Gao C

更新日期：2016-12-01 00:00:00

abstract：:T lymphocytes and B lymphocytes integrate activating signals to control the size of their proliferative response. Here we report that such control was achieved by timed changes in the production rate of cell-cycle-regulating proto-oncoprotein Myc, with division cessation occurring when Myc levels fell below a critical...

journal_title：Nature immunology

authors： Heinzel S,Binh Giang T,Kan A,Marchingo JM,Lye BK,Corcoran LM,Hodgkin PD

更新日期：2017-01-01 00:00:00

abstract：:CD1 proteins present various glycolipid antigens to T cells, but the cellular mechanisms that control which particular glycolipids generate T cell responses are not understood. We show here that T cell recognition of glucose monomycolate antigens with long (C(80)) alkyl chains involves the delivery of CD1b proteins an...

journal_title：Nature immunology

authors： Moody DB,Briken V,Cheng TY,Roura-Mir C,Guy MR,Geho DH,Tykocinski ML,Besra GS,Porcelli SA

更新日期：2002-05-01 00:00:00

abstract：:B lymphocyte development and selection are central to adaptive immunity and self-tolerance. These processes require B cell receptor (BCR) signaling and occur in bone marrow, an environment with variable hypoxia, but whether hypoxia-inducible factor (HIF) is involved is unknown. We show that HIF activity is high in hum...

journal_title：Nature immunology

authors： Burrows N,Bashford-Rogers RJM,Bhute VJ,Peñalver A,Ferdinand JR,Stewart BJ,Smith JEG,Deobagkar-Lele M,Giudice G,Connor TM,Inaba A,Bergamaschi L,Smith S,Tran MGB,Petsalaki E,Lyons PA,Espeli M,Huntly BJP,Smith KGC,Corn

更新日期：2020-11-01 00:00:00

abstract：:Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific o...

journal_title：Nature immunology

authors： Netea MG,Balkwill F,Chonchol M,Cominelli F,Donath MY,Giamarellos-Bourboulis EJ,Golenbock D,Gresnigt MS,Heneka MT,Hoffman HM,Hotchkiss R,Joosten LAB,Kastner DL,Korte M,Latz E,Libby P,Mandrup-Poulsen T,Mantovani A,Mills

更新日期：2017-07-19 00:00:00

abstract：:Robert L. Coffman recounts how his work on immunoglobulin E regulation along with data from Tim Mosmann on the functional heterogeneity of T cell clones led to the T helper type 1-T helper type 2 hypothesis. ...

journal_title：Nature immunology

authors： Coffman RL

更新日期：2006-06-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) and CD4+ type 2 helper T cells (TH2 cells) are defined by their similar effector cytokines, which together mediate the features of allergic immunity. We found that tissue ILC2s and TH2 cells differentiated independently but shared overlapping effector function programs that were m...

journal_title：Nature immunology

authors： Van Dyken SJ,Nussbaum JC,Lee J,Molofsky AB,Liang HE,Pollack JL,Gate RE,Haliburton GE,Ye CJ,Marson A,Erle DJ,Locksley RM

更新日期：2016-12-01 00:00:00

abstract：:The molecular mechanisms directing the development of 'natural' CD4+CD25+Foxp3+ regulatory T cells (T(reg) cells) in the thymus are not thoroughly understood. We show here that conditional deletion of transforming growth factor-beta receptor I (TbetaRI) in T cells blocked the appearance of CD4+CD25+Foxp3+ thymocytes a...

journal_title：Nature immunology

authors： Liu Y,Zhang P,Li J,Kulkarni AB,Perruche S,Chen W

更新日期：2008-06-01 00:00:00

abstract：:The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-posit...

journal_title：Nature immunology

authors： Bischoff V,Vignal C,Boneca IG,Michel T,Hoffmann JA,Royet J

更新日期：2004-11-01 00:00:00

abstract：:CD25(+)CD4(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18)--a member of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor gen...

journal_title：Nature immunology

authors： Shimizu J,Yamazaki S,Takahashi T,Ishida Y,Sakaguchi S

更新日期：2002-02-01 00:00:00

abstract：:The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we iden...

journal_title：Nature immunology

authors： Bender TP,Kremer CS,Kraus M,Buch T,Rajewsky K

更新日期：2004-07-01 00:00:00

abstract：:High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear. We show that the saturated fatty acid palmitate, b...

journal_title：Nature immunology

authors： Wen H,Gris D,Lei Y,Jha S,Zhang L,Huang MT,Brickey WJ,Ting JP

更新日期：2011-05-01 00:00:00

abstract：:In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways ...

journal_title：Nature immunology

authors： Lanna A,Henson SM,Escors D,Akbar AN

更新日期：2014-10-01 00:00:00

abstract：:Intestinal microfold cells (M cells) are an enigmatic lineage of intestinal epithelial cells that initiate mucosal immune responses through the uptake and transcytosis of luminal antigens. The mechanisms of M-cell differentiation are poorly understood, as the rarity of these cells has hampered analysis. Exogenous admi...

journal_title：Nature immunology

authors： Kanaya T,Hase K,Takahashi D,Fukuda S,Hoshino K,Sasaki I,Hemmi H,Knoop KA,Kumar N,Sato M,Katsuno T,Yokosuka O,Toyooka K,Nakai K,Sakamoto A,Kitahara Y,Jinnohara T,McSorley SJ,Kaisho T,Williams IR,Ohno H

更新日期：2012-06-17 00:00:00

abstract：:This corrects the article DOI: 10.1038/ni.3713. ...

journal_title：Nature immunology

authors： Mariño E,Richards JL,McLeod KH,Stanley D,Yap YA,Knight J,McKenzie C,Kranich J,Oliveira AC,Rossello FJ,Krishnamurthy B,Nefzger CM,Macia L,Thorburn A,Baxter AG,Morahan G,Wong LH,Polo JM,Moore RJ,Lockett TJ,Clarke JM

更新日期：2017-10-18 00:00:00

abstract：:Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-beta (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression ...

journal_title：Nature immunology

authors： Karaghiosoff M,Steinborn R,Kovarik P,Kriegshäuser G,Baccarini M,Donabauer B,Reichart U,Kolbe T,Bogdan C,Leanderson T,Levy D,Decker T,Müller M

更新日期：2003-05-01 00:00:00

abstract：:TET proteins oxidize 5-methylcytosine in DNA to 5-hydroxymethylcytosine and other oxidation products. We found that simultaneous deletion of Tet2 and Tet3 in mouse CD4+CD8+ double-positive thymocytes resulted in dysregulated development and proliferation of invariant natural killer T cells (iNKT cells). Tet2-Tet3 doub...

journal_title：Nature immunology

authors： Tsagaratou A,González-Avalos E,Rautio S,Scott-Browne JP,Togher S,Pastor WA,Rothenberg EV,Chavez L,Lähdesmäki H,Rao A

更新日期：2017-01-01 00:00:00

abstract：:Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β. One therapy for type 2 diabetes, g...

journal_title：Nature immunology

authors： Masters SL,Dunne A,Subramanian SL,Hull RL,Tannahill GM,Sharp FA,Becker C,Franchi L,Yoshihara E,Chen Z,Mullooly N,Mielke LA,Harris J,Coll RC,Mills KH,Mok KH,Newsholme P,Nuñez G,Yodoi J,Kahn SE,Lavelle EC,O'Neill

更新日期：2010-10-01 00:00:00

abstract：:Store-operated Ca2+ entry through calcium release-activated calcium channels is the chief mechanism for increasing intracellular Ca2+ in immune cells. Here we show that mouse T cells and fibroblasts lacking the calcium sensor STIM1 had severely impaired store-operated Ca2+ influx, whereas deficiency in the calcium sen...

journal_title：Nature immunology

authors： Oh-Hora M,Yamashita M,Hogan PG,Sharma S,Lamperti E,Chung W,Prakriya M,Feske S,Rao A

更新日期：2008-04-01 00:00:00

abstract：:Chemoattractant-stimulated granule release from neutrophils, basophils and eosinophils is critical for the innate immune response against infectious bacteria. Interleukin 8 (IL-8) activation of the chemokine receptor CXCRI was found to stimulate rapid formation of beta-arrestin complexes with Hck or c-Fgr. Formation o...

journal_title：Nature immunology

authors： Barlic J,Andrews JD,Kelvin AA,Bosinger SE,DeVries ME,Xu L,Dobransky T,Feldman RD,Ferguson SS,Kelvin DJ

更新日期：2000-09-01 00:00:00

abstract：:Vaccines against important enteric pathogens such as rotavirus and poliovirus have shown lower efficacy in some populations. The application of new technologies and diverse scientific disciplines are needed to realize the promise of truly universal and effective solutions to combat those and other enteric diseases. ...

journal_title：Nature immunology

authors： Serazin AC,Shackelton LA,Wilson C,Bhan MK

更新日期：2010-09-01 00:00:00