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Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells.

Abstract：

:Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation. However, it is not known why CD4(+) T cells undergo less-efficient homeostatic proliferation than CD8(+) T cells do. Here we show that systemic IL-7 concentrations increased during lymphopenia because of diminished use of IL-7 but that IL-7 signaling on IL-7 receptor-alpha-positive (IL-7Ralpha(+)) dendritic cells (DCs) in lymphopenic settings paradoxically diminished the homeostatic proliferation of CD4(+) T cells. This effect was mediated at least in part by IL-7-mediated downregulation of the expression of major histocompatibility complex class II on IL-7Ralpha(+) DCs. Our results indicate that IL-7Ralpha(+) DCs are regulators of the peripheral CD4(+) T cell niche and that IL-7 signals in DCs prevent uncontrolled CD4(+) T cell population expansion in vivo.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Guimond M,Veenstra RG,Grindler DJ,Zhang H,Cui Y,Murphy RD,Kim SY,Na R,Hennighausen L,Kurtulus S,Erman B,Matzinger P,Merchant MS,Mackall CL

doi

10.1038/ni.1695

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

149-57

issue

2

eissn

1529-2908

issn

1529-2916

pii

ni.1695

journal_volume

10

pub_type

杂志文章

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