Abstract:
:Phagocytosis has essential functions in immunity. Here we highlight the presence of a subcellular level of self-non-self discrimination in dendritic cells that operates at the level of individual phagosomes. We discuss how engagement of Toll-like receptor signaling controls distinct programs of phagosome maturation. An inducible mode of phagosome maturation triggered by these receptors ensures the selection of microbial antigens for presentation by major histocompatibility class II molecules during the simultaneous phagocytosis of self and non-self.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Blander JM,Medzhitov Rdoi
10.1038/ni1006-1029subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1029-35issue
10eissn
1529-2908issn
1529-2916pii
ni1006-1029journal_volume
7pub_type
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