Abstract:
:EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (TH1) cell-mediated autoimmune disease, it can also be induced by TH2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is associated with exposure to a foreign antigen that is often derived from medication, insect venom or food. We report here that, after self-tolerance to myelin is destroyed, anaphylaxis may be triggered by a self-antigen, in this case a myelin peptide. "Horror autotoxicus", which was initially described by Ehrlich, may not only include autoimmunity to self, it may also encompass immediate hypersensitivity to self, which leads to shock and rapid death.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Pedotti R,Mitchell D,Wedemeyer J,Karpuj M,Chabas D,Hattab EM,Tsai M,Galli SJ,Steinman Ldoi
10.1038/85266keywords:
subject
Has Abstractpub_date
2001-03-01 00:00:00pages
216-22issue
3eissn
1529-2908issn
1529-2916journal_volume
2pub_type
杂志文章abstract::Mice deficient in the adaptor Ndfip1 develop inflammation at sites of environmental antigen exposure. We show here that such mice had fewer inducible regulatory T cells (iT(reg) cells). In vitro, Ndfip1-deficient T cells expressed normal amounts of the transcription factor Foxp3 during the first 48 h of iT(reg) cell d...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2154
更新日期:2011-11-13 00:00:00
abstract::The autoimmune regulator Aire is expressed in a small proportion of medullary thymic epithelial cells (mTECs) and is crucial in the induction of central T cell tolerance. The origin and development of Aire(+) mTECs, however, are not well understood. Here we demonstrate that the tight-junction components claudin-3 and ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1438
更新日期:2007-03-01 00:00:00
abstract::Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestra...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.1937
更新日期:2010-10-01 00:00:00
abstract::Induction of the antiviral innate immune response depends on recognition of viral components by host pattern-recognition receptors. Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids. Toll-like receptor signaling results in the production of type ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1303
更新日期:2006-02-01 00:00:00
abstract::We define here the specificity and significance of proteases in the endoplasmic reticulum (ER) that generate peptides for presentation by major histocompatibility complex (MHC) class I molecules. We show that aminopeptidases efficiently trimmed all residues except proline that flank the NH2-termini of antigenic precur...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/89800
更新日期:2001-07-01 00:00:00
abstract::Autoreactive T cells are eliminated in the thymus to prevent autoimmunity by promiscuous expression of tissue-restricted self-antigens in medullary thymic epithelial cells. This expression is dependent on the transcription factor Fezf2, as well as the transcriptional regulator Aire, but the entire picture of the trans...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0717-2
更新日期:2020-08-01 00:00:00
abstract::The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1017
更新日期:2004-01-01 00:00:00
abstract::Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-complex adaptor, binds and stabilizes mRNAs encoding key inflammatory proteins. The Act1 SEFIR domain binds a stem-loop structure, the SEFIR-bind...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0071-9
更新日期:2018-04-01 00:00:00
abstract::The survival of T lymphocytes requires sustained, Ca(2+) influx-dependent gene expression. The molecular mechanism that governs sustained Ca(2+) influx in naive T lymphocytes is unknown. Here we report an essential role for the beta3 regulatory subunit of voltage-gated calcium (Ca(v)) channels in the maintenance of na...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1793
更新日期:2009-12-01 00:00:00
abstract::Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate t...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0176-1
更新日期:2018-09-01 00:00:00
abstract::Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptive immunity. Although intense effort has been devoted to studying the regulation and requirements...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1201-1103
更新日期:2001-12-01 00:00:00
abstract::The cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the parenchyma. T cells deficient in sphingosine 1-phosphate receptor ty...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1682
更新日期:2009-01-01 00:00:00
abstract::Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3227
更新日期:2015-09-01 00:00:00
abstract::Intestinal microfold cells (M cells) are an enigmatic lineage of intestinal epithelial cells that initiate mucosal immune responses through the uptake and transcytosis of luminal antigens. The mechanisms of M-cell differentiation are poorly understood, as the rarity of these cells has hampered analysis. Exogenous admi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2352
更新日期:2012-06-17 00:00:00
abstract::Antibody specificity and diversity is generated in B cells during germinal center maturation through clonal expansion while they undergo class-switch recombination and somatic hypermutation. Here we demonstrate that the transcriptional repressor Bcl-6 mediates this phenotype by directly repressing ATR in centroblasts ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1478
更新日期:2007-07-01 00:00:00
abstract::Toll-like receptor 2 (TLR2) initiates inflammation in response to bacterial lipopeptide (BLP). However, the molecular mechanisms enabling the detection of BLP by TLR2 are unknown. Here we investigated the interaction of BLP with human serum proteins and identified vitronectin as a BLP-recognition molecule. Vitronectin...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1618
更新日期:2008-07-01 00:00:00
abstract::The duration of T cell receptor (TCR) signaling is thought to be important for thymocyte differentiation into the CD4 or CD8 lineage. However, the in vivo relevance of this hypothesis is unclear. Here we divided T cell positive selection into genetically separable developmental steps by confining TCR signal transducti...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1040
更新日期:2004-03-01 00:00:00
abstract::Myxoma virus, a member of the poxvirus family, causes lethal infection only in rabbits, but the mechanism underlying the strict myxoma virus species barrier is not known. Here we show that myxoma virus infection of primary mouse embryo fibroblasts elicited extracellular signal-regulated kinase (Erk) signaling, which w...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1132
更新日期:2004-12-01 00:00:00
abstract::Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threa...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-00826-9
更新日期:2021-01-01 00:00:00
abstract::Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation. However, it is not known why CD4(+) T cells undergo less-efficient homeostatic proliferation than CD8(+) T cells do. Here we show that systemic IL-7 concentrations increased during ly...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1695
更新日期:2009-02-01 00:00:00
abstract::Regulatory T cells (T(reg) cells) develop from progenitor thymocytes after the engagement of T cell antigen receptors (TCRs) with high-affinity ligands, but the underlying molecular mechanisms are still unclear. Here we show that the Nr4a nuclear receptors, which are encoded by immediate-early genes upregulated by TCR...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2520
更新日期:2013-03-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41590-020-0665-x
更新日期:2020-06-01 00:00:00
abstract::Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These st...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1116
更新日期:2004-10-01 00:00:00
abstract::T lymphocytes and B lymphocytes integrate activating signals to control the size of their proliferative response. Here we report that such control was achieved by timed changes in the production rate of cell-cycle-regulating proto-oncoprotein Myc, with division cessation occurring when Myc levels fell below a critical...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3598
更新日期:2017-01-01 00:00:00
abstract::Toll-like receptors (TLRs) are key initiators of the innate immune response and promote adaptive immunity. Much has been learned about the role of TLRs in human immunity from studies linking TLR genetic variation with disease. First, monogenic disorders associated with complete deficiency in certain TLR pathways, such...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2284
更新日期:2012-05-18 00:00:00
abstract::The Greek island of Crete became host to lively discussions on immunoregulation as experts from around the world gathered for the 7th Aegean Conference on Autoimmunity in September 2015. ...
journal_title:Nature immunology
pub_type:
doi:10.1038/ni.3367
更新日期:2016-03-01 00:00:00
abstract::Notch molecules are well conserved from Drosophila melanogaster to mammals and regulate a broad spectrum of various cell lineage commitment processes. Recent studies using inhibitors, transgenic mice and conditional loss-of-function approaches have demonstrated essential roles for Notch signaling in the differentiatio...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1453
更新日期:2007-05-01 00:00:00
abstract::We evaluated changes in the signaling potentials and proliferative capacity of single antigen-specific T helper (TH) cells during a primary immune response to a protein antigen. At the peak of cellular expansion in vivo all antigen-specific TH cells exhibited a profound block in CD3- and CD4-mediated mobilization of i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/80841
更新日期:2000-11-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-019-0531-x
更新日期:2019-11-01 00:00:00
abstract::Plant proteins belonging to the nucleotide-binding site-leucine-rich repeat (NBS-LRR) family are used for pathogen detection. Like the mammalian Nod-LRR protein 'sensors' that detect intracellular conserved pathogen-associated molecular patterns, plant NBS-LRR proteins detect pathogen-associated proteins, most often t...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1410
更新日期:2006-12-01 00:00:00