Toll-like receptors in the pathogenesis of human disease.

Abstract:

:Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma. As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Cook DN,Pisetsky DS,Schwartz DA

doi

10.1038/ni1116

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

975-9

issue

10

eissn

1529-2908

issn

1529-2916

pii

ni1116

journal_volume

5

pub_type

杂志文章,评审
  • A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties.

    abstract::Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(α)14-J(α)18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.2051

    authors: Uldrich AP,Patel O,Cameron G,Pellicci DG,Day EB,Sullivan LC,Kyparissoudis K,Kjer-Nielsen L,Vivian JP,Cao B,Brooks AG,Williams SJ,Illarionov P,Besra GS,Turner SJ,Porcelli SA,McCluskey J,Smyth MJ,Rossjohn J,Godfrey DI

    更新日期:2011-06-12 00:00:00

  • Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.

    abstract::Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the T(H)17 subset of helper T cells in the lungs...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.3008

    authors: Jeltsch KM,Hu D,Brenner S,Zöller J,Heinz GA,Nagel D,Vogel KU,Rehage N,Warth SC,Edelmann SL,Gloury R,Martin N,Lohs C,Lech M,Stehklein JE,Geerlof A,Kremmer E,Weber A,Anders HJ,Schmitz I,Schmidt-Supprian M,Fu M,H

    更新日期:2014-11-01 00:00:00

  • Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.

    abstract::Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution co...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.2490

    authors: Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB,ImmGen Project Consortium.

    更新日期:2013-01-01 00:00:00

  • Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels.

    abstract::CRACM1 (also called Orai1) constitutes the pore subunit of store-operated calcium release-activated calcium channels. A point mutation in the gene encoding CRACM1 is associated with severe combined immunodeficiency disease in humans. Here we generated CRACM1-deficient mice in which beta-galactosidase activity 'reporte...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1550

    authors: Vig M,DeHaven WI,Bird GS,Billingsley JM,Wang H,Rao PE,Hutchings AB,Jouvin MH,Putney JW,Kinet JP

    更新日期:2008-01-01 00:00:00

  • Different molecular complexes that mediate transcriptional induction and repression by FoxP3.

    abstract::FoxP3 conditions the transcriptional signature and functional facets of regulatory T cells (Treg cells). Its mechanism of action, whether as an activator or a repressor, has remained unclear. Here, chromatin analysis showed that FoxP3 bound active enhancer elements, not repressed chromatin, around loci over- or under-...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.3835

    authors: Kwon HK,Chen HM,Mathis D,Benoist C

    更新日期:2017-11-01 00:00:00

  • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.

    abstract::CD4(+) T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (T(H)1) or T(H)2 lineages and instead favor the idea of a d...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1254

    authors: Harrington LE,Hatton RD,Mangan PR,Turner H,Murphy TL,Murphy KM,Weaver CT

    更新日期:2005-11-01 00:00:00

  • Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation.

    abstract::A20 is an anti-inflammatory protein that is strongly linked to human disease. Here, we find that mice expressing three distinct targeted mutations of A20's zinc finger 7 (ZF7) ubiquitin-binding motif uniformly developed digit arthritis with features common to psoriatic arthritis, while mice expressing point mutations ...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/s41590-020-0634-4

    authors: Razani B,Whang MI,Kim FS,Nakamura MC,Sun X,Advincula R,Turnbaugh JA,Pendse M,Tanbun P,Achacoso P,Turnbaugh PJ,Malynn BA,Ma A

    更新日期:2020-04-01 00:00:00

  • Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

    abstract::DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on myeloid cells and natural killer cells. We examine here the responses of mice lacking DAP12 to stimulation through Toll-like receptors (TLRs). Unexpectedly, DAP12-deficient macrophages produced...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1204

    authors: Hamerman JA,Tchao NK,Lowell CA,Lanier LL

    更新日期:2005-06-01 00:00:00

  • Apoptosis in the development and maintenance of the immune system.

    abstract::Programmed cell death is essential for the development and maintenance of cellular homeostasis of the immune system. The Bcl-2 family of proteins comprises both pro-apoptotic and anti-apoptotic members. A subset of pro-apoptotic members, called 'BH3-only' proteins, share sequence homology only in the minimal death dom...

    journal_title:Nature immunology

    pub_type: 杂志文章,评审

    doi:10.1038/ni0503-410

    authors: Opferman JT,Korsmeyer SJ

    更新日期:2003-05-01 00:00:00

  • B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities.

    abstract::The present paradigm dictates that phagocytosis is accomplished mainly by 'professional' phagocytes (such as macrophages and monocytes), whereas B cells lack phagocytic capabilities. Here we demonstrate that B cells from teleost fish have potent in vitro and in vivo phagocytic activities. Particle uptake by B cells in...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1389

    authors: Li J,Barreda DR,Zhang YA,Boshra H,Gelman AE,Lapatra S,Tort L,Sunyer JO

    更新日期:2006-10-01 00:00:00

  • Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.

    abstract::Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an interleukin 27 (IL-27)-d...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.1772

    authors: Ilarregui JM,Croci DO,Bianco GA,Toscano MA,Salatino M,Vermeulen ME,Geffner JR,Rabinovich GA

    更新日期:2009-09-01 00:00:00

  • CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator.

    abstract::CD160, a glycosylphosphatidylinositol-anchored member of the immunoglobulin superfamily, is expressed on both cytolytic lymphocytes and some unstimulated CD4+ T cells. Here we show that CD160 expression was increased after activation of human CD4+ T cells and that crosslinking CD160 with monoclonal antibody strongly i...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1554

    authors: Cai G,Anumanthan A,Brown JA,Greenfield EA,Zhu B,Freeman GJ

    更新日期:2008-02-01 00:00:00

  • Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors.

    abstract::The origin and specification of human dendritic cells (DCs) have not been investigated at the clonal level. Through the use of clonal assays, combined with statistical computation, to quantify the yield of granulocytes, monocytes, lymphocytes and three subsets of DCs from single human CD34+ progenitor cells, we found ...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.3789

    authors: Lee J,Zhou YJ,Ma W,Zhang W,Aljoufi A,Luh T,Lucero K,Liang D,Thomsen M,Bhagat G,Shen Y,Liu K

    更新日期:2017-08-01 00:00:00

  • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.

    abstract::Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β. One therapy for type 2 diabetes, g...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.1935

    authors: Masters SL,Dunne A,Subramanian SL,Hull RL,Tannahill GM,Sharp FA,Becker C,Franchi L,Yoshihara E,Chen Z,Mullooly N,Mielke LA,Harris J,Coll RC,Mills KH,Mok KH,Newsholme P,Nuñez G,Yodoi J,Kahn SE,Lavelle EC,O'Neill

    更新日期:2010-10-01 00:00:00

  • The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells.

    abstract::CD4(+) follicular helper T cells (T(FH) cells) are essential for germinal center (GC) responses and long-lived antibody responses. Here we report that naive CD4(+) T cells deficient in the transcription factor Foxp1 'preferentially' differentiated into T(FH) cells, which resulted in substantially enhanced GC and antib...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.2890

    authors: Wang H,Geng J,Wen X,Bi E,Kossenkov AV,Wolf AI,Tas J,Choi YS,Takata H,Day TJ,Chang LY,Sprout SL,Becker EK,Willen J,Tian L,Wang X,Xiao C,Jiang P,Crotty S,Victora GD,Showe LC,Tucker HO,Erikson J,Hu H

    更新日期:2014-07-01 00:00:00

  • Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils.

    abstract::The Fc receptor common gamma-chain (FcRgamma) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcRgamma developed normally and proliferated efficiently in response to inter...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.1686

    authors: Hida S,Yamasaki S,Sakamoto Y,Takamoto M,Obata K,Takai T,Karasuyama H,Sugane K,Saito T,Taki S

    更新日期:2009-02-01 00:00:00

  • Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment.

    abstract::Hematopoiesis requires tight regulation of the hematopoietic stem cell (HSC) population; however, the dynamics of HSC use at steady state are uncertain. Over 3-7 months, we evaluated the repopulation and self-renewal of more than 600 individual human 'severe combined immunodeficiency mouse-repopulating cells' (SRCs), ...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1393

    authors: McKenzie JL,Gan OI,Doedens M,Wang JC,Dick JE

    更新日期:2006-11-01 00:00:00

  • Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.

    abstract::The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoi...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.1789

    authors: van de Pavert SA,Olivier BJ,Goverse G,Vondenhoff MF,Greuter M,Beke P,Kusser K,Höpken UE,Lipp M,Niederreither K,Blomhoff R,Sitnik K,Agace WW,Randall TD,de Jonge WJ,Mebius RE

    更新日期:2009-11-01 00:00:00

  • Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii.

    abstract::Toxoplasma gondii is a common protozoan parasite that infects up to one third of the world's population. Notably, very little is known about innate immune sensing mechanisms for this obligate intracellular parasite by human cells. Here, by applying an unbiased biochemical screening approach, we show that human monocyt...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/s41590-018-0250-8

    authors: Safronova A,Araujo A,Camanzo ET,Moon TJ,Elliott MR,Beiting DP,Yarovinsky F

    更新日期:2019-01-01 00:00:00

  • Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.

    abstract::The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against influenza. Here we designed a vaccine using the hypervariable recepto...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/s41590-018-0305-x

    authors: Kanekiyo M,Joyce MG,Gillespie RA,Gallagher JR,Andrews SF,Yassine HM,Wheatley AK,Fisher BE,Ambrozak DR,Creanga A,Leung K,Yang ES,Boyoglu-Barnum S,Georgiev IS,Tsybovsky Y,Prabhakaran MS,Andersen H,Kong WP,Baxa U,Zephi

    更新日期:2019-03-01 00:00:00

  • Chd4 choreographs self-antigen expression for central immune tolerance.

    abstract::Autoreactive T cells are eliminated in the thymus to prevent autoimmunity by promiscuous expression of tissue-restricted self-antigens in medullary thymic epithelial cells. This expression is dependent on the transcription factor Fezf2, as well as the transcriptional regulator Aire, but the entire picture of the trans...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/s41590-020-0717-2

    authors: Tomofuji Y,Takaba H,Suzuki HI,Benlaribi R,Martinez CDP,Abe Y,Morishita Y,Okamura T,Taguchi A,Kodama T,Takayanagi H

    更新日期:2020-08-01 00:00:00

  • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance.

    abstract::CD25(+)CD4(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18)--a member of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor gen...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni759

    authors: Shimizu J,Yamazaki S,Takahashi T,Ishida Y,Sakaguchi S

    更新日期:2002-02-01 00:00:00

  • Interleukin 15 controls the generation of the restricted T cell receptor repertoire of gamma delta intestinal intraepithelial lymphocytes.

    abstract::The gammadelta T cells are prevalent in the mucosal epithelia and are postulated to act as 'sentries' for maintaining tissue integrity. What these gammadelta T cells recognize is poorly defined, but given the restricted T cell receptor (TCR) repertoire, the idea that they are selected by self antigens of low complexit...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1267

    authors: Zhao H,Nguyen H,Kang J

    更新日期:2005-12-01 00:00:00

  • The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.

    abstract::Autoreactive B cells have critical roles in a large diversity of autoimmune diseases, but the molecular pathways that control these cells remain poorly understood. We performed an in vivo functional screen of a lymphocyte-expressed microRNA library and identified miR-148a as a potent regulator of B cell tolerance. Ele...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.3385

    authors: Gonzalez-Martin A,Adams BD,Lai M,Shepherd J,Salvador-Bernaldez M,Salvador JM,Lu J,Nemazee D,Xiao C

    更新日期:2016-04-01 00:00:00

  • Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.

    abstract::Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monoc...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/s41590-019-0568-x

    authors: Aegerter H,Kulikauskaite J,Crotta S,Patel H,Kelly G,Hessel EM,Mack M,Beinke S,Wack A

    更新日期:2020-02-01 00:00:00

  • CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.

    abstract::The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/76957

    authors: Aliberti J,Reis e Sousa C,Schito M,Hieny S,Wells T,Huffnagle GB,Sher A

    更新日期:2000-07-01 00:00:00

  • Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.

    abstract::Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestra...

    journal_title:Nature immunology

    pub_type: 杂志文章,评审

    doi:10.1038/ni.1937

    authors: Biswas SK,Mantovani A

    更新日期:2010-10-01 00:00:00

  • Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.

    abstract::Inhibitory natural killer (NK) cell receptors down-regulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. We report here the crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to i...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/87766

    authors: Fan QR,Long EO,Wiley DC

    更新日期:2001-05-01 00:00:00

  • Molecular definition of the identity and activation of natural killer cells.

    abstract::Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cel...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.2395

    authors: Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL,Immunological Genome Project Consortium.

    更新日期:2012-10-01 00:00:00

  • The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

    abstract::The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell b...

    journal_title:Nature immunology

    pub_type: 杂志文章,评审

    doi:10.1038/76877

    authors: Dustin ML,Cooper JA

    更新日期:2000-07-01 00:00:00