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Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier.

Abstract：

:Myxoma virus, a member of the poxvirus family, causes lethal infection only in rabbits, but the mechanism underlying the strict myxoma virus species barrier is not known. Here we show that myxoma virus infection of primary mouse embryo fibroblasts elicited extracellular signal-regulated kinase (Erk) signaling, which was integrated to interferon regulatory factor 3 activation and type I interferon induction. We further show that Erk inactivation or disruption of interferon signaling mediated by the transcription factor STAT1 broke the cellular blockade to myxoma virus multiplication. Moreover, STAT1 deficiency rendered mice highly susceptible to lethal myxoma virus infection. Thus, the Erk-interferon-STAT1 signaling cascade elicited by myxoma virus in nonpermissive primary mouse embryo fibroblasts mediates an innate cellular barrier to poxvirus infection.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Wang F,Ma Y,Barrett JW,Gao X,Loh J,Barton E,Virgin HW,McFadden G

doi

10.1038/ni1132

keywords:

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

1266-74

issue

12

eissn

1529-2908

issn

1529-2916

pii

ni1132

journal_volume

5

pub_type

杂志文章

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