Abstract:
:Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T (Treg) cells as a distinct, highly suppressive population of Treg cells that mediate wound healing. These Treg cells were enriched in intestinal lamina propria, particularly in Crohn's disease. CD161+ Treg cells had an all-trans retinoic acid (ATRA)-regulated gene signature, and CD161 expression on Treg cells was induced by ATRA, which directly regulated the CD161 gene. CD161 was co-stimulatory, and ligation with the T cell antigen receptor induced cytokines that accelerated the wound healing of intestinal epithelial cells. We identified a transcription-factor network, including BACH2, RORγt, FOSL2, AP-1 and RUNX1, that controlled expression of the wound-healing program, and found a CD161+ Treg cell signature in Crohn's disease mucosa associated with reduced inflammation. These findings identify CD161+ Treg cells as a population involved in controlling the balance between inflammation and epithelial barrier healing in the gut.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Povoleri GAM,Nova-Lamperti E,Scottà C,Fanelli G,Chen YC,Becker PD,Boardman D,Costantini B,Romano M,Pavlidis P,McGregor R,Pantazi E,Chauss D,Sun HW,Shih HY,Cousins DJ,Cooper N,Powell N,Kemper C,Pirooznia M,Laurencedoi
10.1038/s41590-018-0230-zsubject
Has Abstractpub_date
2018-12-01 00:00:00pages
1403-1414issue
12eissn
1529-2908issn
1529-2916pii
10.1038/s41590-018-0230-zjournal_volume
19pub_type
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