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Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation.

Abstract：

:A20 is an anti-inflammatory protein that is strongly linked to human disease. Here, we find that mice expressing three distinct targeted mutations of A20's zinc finger 7 (ZF7) ubiquitin-binding motif uniformly developed digit arthritis with features common to psoriatic arthritis, while mice expressing point mutations in A20's OTU or ZF4 motifs did not exhibit this phenotype. Arthritis in A20ZF7 mice required T cells and MyD88, was exquisitely sensitive to tumor necrosis factor and interleukin-17A, and persisted in germ-free conditions. A20ZF7 cells exhibited prolonged IκB kinase activity that drove exaggerated transcription of late-phase nuclear factor-κB response genes in vitro and in prediseased mouse paws in vivo. In addition, mice expressing double-mutant A20 proteins in A20's ZF4 and ZF7 motifs died perinatally with multi-organ inflammation. Therefore, A20's ZF4 and ZF7 motifs synergistically prevent inflammatory disease in a non-catalytic manner.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Razani B,Whang MI,Kim FS,Nakamura MC,Sun X,Advincula R,Turnbaugh JA,Pendse M,Tanbun P,Achacoso P,Turnbaugh PJ,Malynn BA,Ma A

doi

10.1038/s41590-020-0634-4

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

422-433

issue

4

eissn

1529-2908

issn

1529-2916

pii

10.1038/s41590-020-0634-4

journal_volume

21

pub_type

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