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Patterns of nonclassical MHC antigen presentation.

Abstract：

:The identification of pattern-recognition receptors that selectively respond to evolutionarily conserved chemical (often pathogen-derived) moieties has provided key insight into how innate immune cells facilitate rapid and relatively specific antimicrobial immune activity. In contrast, relatively slower adaptive immune responses rely on T cell clonal expansion that develops in response to variable peptides bound to the groove of classical major histocompatibility complex (MHC) proteins. For certain nonclassical 'MHC-like' class Ib proteins, such as H2-M3 and CD1d, their respective binding grooves seem to have been adapted to present to T cells unique molecular patterns analogous to those involved in innate signaling. Here we propose that another MHC class Ib protein, MR1, which is required for the gut flora-dependent development of mucosa-associated invariant T cells, presents either a microbe-produced or a microbe-induced pattern.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Hansen TH,Huang S,Arnold PL,Fremont DH

doi

10.1038/ni1475

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

563-8

issue

6

eissn

1529-2908

issn

1529-2916

pii

ni1475

journal_volume

8

pub_type

杂志文章

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