Abstract:
:Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved understanding of the immunological processes that regulate obesity may yield new treatments for obesity-associated disorders.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Kanneganti TD,Dixit VDdoi
10.1038/ni.2343subject
Has Abstractpub_date
2012-07-19 00:00:00pages
707-12issue
8eissn
1529-2908issn
1529-2916pii
ni.2343journal_volume
13pub_type
杂志文章abstract::Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed c...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2159
更新日期:2011-11-16 00:00:00
abstract::The origin and specification of human dendritic cells (DCs) have not been investigated at the clonal level. Through the use of clonal assays, combined with statistical computation, to quantify the yield of granulocytes, monocytes, lymphocytes and three subsets of DCs from single human CD34+ progenitor cells, we found ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3789
更新日期:2017-08-01 00:00:00
abstract::Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation. However, it is not known why CD4(+) T cells undergo less-efficient homeostatic proliferation than CD8(+) T cells do. Here we show that systemic IL-7 concentrations increased during ly...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1695
更新日期:2009-02-01 00:00:00
abstract::The thiol-oxidoreductase ERp57 is an integral component of the peptide-loading complex of the major histocompatibility complex (MHC) class I pathway, but its function is unknown. To investigate its function in antigen presentation, we generated ERp57-deficient mice. Death in utero caused by ubiquitous ERp57 deletion w...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1288
更新日期:2006-01-01 00:00:00
abstract::Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a pa...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1814
更新日期:2009-12-01 00:00:00
abstract::CD160, a glycosylphosphatidylinositol-anchored member of the immunoglobulin superfamily, is expressed on both cytolytic lymphocytes and some unstimulated CD4+ T cells. Here we show that CD160 expression was increased after activation of human CD4+ T cells and that crosslinking CD160 with monoclonal antibody strongly i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1554
更新日期:2008-02-01 00:00:00
abstract::The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte assembles a unique VLR by rearrangement of the germline gene. In the lamprey genome, we identify here about 850 distinct cassettes encoding leucine-ri...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1463
更新日期:2007-06-01 00:00:00
abstract::Microbial DNA sequences containing unmethylated CpG dinucleotides activate Toll-like receptor 9 (TLR9). We have found that TLR9 is localized to the endoplasmic reticulum (ER) of dendritic cells (DCs) and macrophages. Because there is no precedent for immune receptor signaling in the ER, we investigated how TLR9 is act...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1028
更新日期:2004-02-01 00:00:00
abstract::Phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN) phosphatase serve essential functions in the regulation of cell growth, differentiation and survival by modulating intracellular phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) concentrations. Here we show that the conditional deletion o...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni892
更新日期:2003-03-01 00:00:00
abstract::To investigate if the microRNA (miRNA) pathway is required for dendritic cell (DC) development, we assessed the effect of ablating Drosha and Dicer, the two enzymes central to miRNA biogenesis. We found that while Dicer deficiency had some effect, Drosha deficiency completely halted DC development and halted myelopoie...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3293
更新日期:2015-11-01 00:00:00
abstract::Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In add...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.3273
更新日期:2015-10-01 00:00:00
abstract::The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic insufficiency can imprint permanent T cell dysfunction. We found that TILs accumulated depolarized mitochondria as a res...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0793-3
更新日期:2020-12-01 00:00:00
abstract::Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define alternative activation states. We found that RBP-J, the main nuclear transducer of signaling via Notch receptors, augmented Toll-like receptor 4 (TLR4)-induced expression of key mediators of classic...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2304
更新日期:2012-05-20 00:00:00
abstract::Notch molecules are well conserved from Drosophila melanogaster to mammals and regulate a broad spectrum of various cell lineage commitment processes. Recent studies using inhibitors, transgenic mice and conditional loss-of-function approaches have demonstrated essential roles for Notch signaling in the differentiatio...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1453
更新日期:2007-05-01 00:00:00
abstract::We used high-resolution mass spectrometry to map the cytotoxic T lymphocyte (CTL) proteome and the effect of the metabolic checkpoint kinase mTORC1 on CTLs. The CTL proteome was dominated by metabolic regulators and granzymes, and mTORC1 selectively repressed and promoted expression of a subset of CTL proteins (~10%)....
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3314
更新日期:2016-01-01 00:00:00
abstract::Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanisms that control CMV-induced immunosuppression. We hypothesized that dendritic cells (DCs), which ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni724
更新日期:2001-11-01 00:00:00
abstract::In addition to the conventional innate and acquired immune responses, complex organisms have evolved an array of dominant, constitutively expressed genes that suppress or prevent viral infections. Two major cellular defenses against infection by retroviruses are the Fv1 and TRIM5 class of inhibitors that target incomi...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1125
更新日期:2004-11-01 00:00:00
abstract::Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3227
更新日期:2015-09-01 00:00:00
abstract::Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the T(H)17 subset of helper T cells in the lungs...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3008
更新日期:2014-11-01 00:00:00
abstract::Genes and pathways in which inactivation dampens tissue inflammation present new opportunities for understanding the pathogenesis of common human inflammatory diseases, including inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis. We identified a mutation in the gene encoding the deubiquitination ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3581
更新日期:2017-01-01 00:00:00
abstract::Hematopoiesis requires tight regulation of the hematopoietic stem cell (HSC) population; however, the dynamics of HSC use at steady state are uncertain. Over 3-7 months, we evaluated the repopulation and self-renewal of more than 600 individual human 'severe combined immunodeficiency mouse-repopulating cells' (SRCs), ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1393
更新日期:2006-11-01 00:00:00
abstract::Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood. Dividing lymphocytes typically rely on aerobic glycolysis over oxidative phosphorylation for energy. Here we report that GCBCs are exceptional amo...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0598-4
更新日期:2020-03-01 00:00:00
abstract::The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated T cells in the lymph node may be crucial in early HIV-1 pathogenesis. We have characterized primary DCs for the receptors involved in viral envelope attachment and observed that C-type lectin receptor (CLR) binding was p...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni841
更新日期:2002-10-01 00:00:00
abstract::We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 (tentati...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni875
更新日期:2003-01-01 00:00:00
abstract::Ebola virus is a highly virulent pathogen capable of inducing a frequently lethal hemorrhagic fever syndrome. Accumulating evidence indicates that the virus actively subverts both innate and adaptive immune responses and triggers harmful inflammatory responses as it inflicts direct tissue damage. The host immune syste...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1519
更新日期:2007-11-01 00:00:00
abstract::The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors, whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of m...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-019-0491-1
更新日期:2019-10-01 00:00:00
abstract::Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/s41590-017-0022-x
更新日期:2018-02-01 00:00:00
abstract:: ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0282-0
更新日期:2019-01-01 00:00:00
abstract:: ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0247-3
更新日期:2018-11-01 00:00:00
abstract::Double-stranded DNA (dsDNA) in the cytoplasm triggers the production of interleukin 1β (IL-1β) as an antiviral host response, and deregulation of the pathways involved can promote inflammatory disease. Here we report a direct cytosolic interaction between the DNA-damage sensor Rad50 and the innate immune system adapto...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2888
更新日期:2014-06-01 00:00:00