Autophagy and autophagy-related proteins in the immune system.

abstract：:B cells are activated by two temporally distinct signals, the first provided by the binding of antigen to the B cell antigen receptor (BCR), and the second provided by helper T cells. Here we found that B cells responded to antigen by rapidly increasing their metabolic activity, including both oxidative phosphorylatio...

journal_title：Nature immunology

authors： Akkaya M,Traba J,Roesler AS,Miozzo P,Akkaya B,Theall BP,Sohn H,Pena M,Smelkinson M,Kabat J,Dahlstrom E,Dorward DW,Skinner J,Sack MN,Pierce SK

更新日期：2018-08-01 00:00:00

abstract：:The identification of pattern-recognition receptors that selectively respond to evolutionarily conserved chemical (often pathogen-derived) moieties has provided key insight into how innate immune cells facilitate rapid and relatively specific antimicrobial immune activity. In contrast, relatively slower adaptive immun...

journal_title：Nature immunology

authors： Hansen TH,Huang S,Arnold PL,Fremont DH

更新日期：2007-06-01 00:00:00

abstract：:While a number of extrinsic factors are known to promote the survival of plasma cells (PCs), the signaling intermediates involved remain poorly characterized. Here we identified inducible nitric oxide synthase (iNOS) as an intermediate that supported the survival of PCs. PCs deficient in iNOS (Nos2(-/-) PCs) showed en...

journal_title：Nature immunology

authors： Saini AS,Shenoy GN,Rath S,Bal V,George A

更新日期：2014-03-01 00:00:00

abstract：:The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-posit...

journal_title：Nature immunology

authors： Bischoff V,Vignal C,Boneca IG,Michel T,Hoffmann JA,Royet J

更新日期：2004-11-01 00:00:00

abstract：:According to current models of hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)Flt3(hi)) and common myeloid progenitors (CMPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage-commitment pathways from hematopoietic stem cells, wi...

journal_title：Nature immunology

authors： Drissen R,Buza-Vidas N,Woll P,Thongjuea S,Gambardella A,Giustacchini A,Mancini E,Zriwil A,Lutteropp M,Grover A,Mead A,Sitnicka E,Jacobsen SEW,Nerlov C

更新日期：2016-06-01 00:00:00

abstract：:The origin and specification of human dendritic cells (DCs) have not been investigated at the clonal level. Through the use of clonal assays, combined with statistical computation, to quantify the yield of granulocytes, monocytes, lymphocytes and three subsets of DCs from single human CD34+ progenitor cells, we found ...

journal_title：Nature immunology

authors： Lee J,Zhou YJ,Ma W,Zhang W,Aljoufi A,Luh T,Lucero K,Liang D,Thomsen M,Bhagat G,Shen Y,Liu K

更新日期：2017-08-01 00:00:00

abstract：:The prevalence of autoimmune disorders in affluent countries has reached epidemic proportions. Over the past 50 years, a reverse trend between the frequency of infectious diseases and the incidence of autoimmune and allergic diseases led to the so-called 'hygiene hypothesis'. Given the epidemiological evidence and rec...

journal_title：Nature immunology

authors： De Rosa V,La Cava A,Matarese G

更新日期：2017-10-18 00:00:00

abstract：:Diverse cellular responses to external cues are controlled by a small number of signal-transduction pathways, but how the specificity of functional outcomes is achieved remains unclear. Here we describe a mechanism for signal integration based on the functional coupling of two distinct signaling pathways widely used i...

journal_title：Nature immunology

authors： Bezbradica JS,Rosenstein RK,DeMarco RA,Brodsky I,Medzhitov R

更新日期：2014-04-01 00:00:00

abstract：:B lymphocyte development and selection are central to adaptive immunity and self-tolerance. These processes require B cell receptor (BCR) signaling and occur in bone marrow, an environment with variable hypoxia, but whether hypoxia-inducible factor (HIF) is involved is unknown. We show that HIF activity is high in hum...

journal_title：Nature immunology

authors： Burrows N,Bashford-Rogers RJM,Bhute VJ,Peñalver A,Ferdinand JR,Stewart BJ,Smith JEG,Deobagkar-Lele M,Giudice G,Connor TM,Inaba A,Bergamaschi L,Smith S,Tran MGB,Petsalaki E,Lyons PA,Espeli M,Huntly BJP,Smith KGC,Corn

更新日期：2020-11-01 00:00:00

abstract：:Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, is the substrate for protein geranylgeranylation, a protein post-transl...

journal_title：Nature immunology

authors： Akula MK,Shi M,Jiang Z,Foster CE,Miao D,Li AS,Zhang X,Gavin RM,Forde SD,Germain G,Carpenter S,Rosadini CV,Gritsman K,Chae JJ,Hampton R,Silverman N,Gravallese EM,Kagan JC,Fitzgerald KA,Kastner DL,Golenbock DT,Ber

更新日期：2016-08-01 00:00:00

abstract：:Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution co...

journal_title：Nature immunology

authors： Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB,ImmGen Project Consortium.

更新日期：2013-01-01 00:00:00

abstract：:Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T (Treg) cells as a distinct, highly suppressive population of Treg cells that mediate wound healing. These Treg cells were enriched in intestinal...

journal_title：Nature immunology

authors： Povoleri GAM,Nova-Lamperti E,Scottà C,Fanelli G,Chen YC,Becker PD,Boardman D,Costantini B,Romano M,Pavlidis P,McGregor R,Pantazi E,Chauss D,Sun HW,Shih HY,Cousins DJ,Cooper N,Powell N,Kemper C,Pirooznia M,Laurence

更新日期：2018-12-01 00:00:00

abstract：:The kappa intronic (MiE(kappa)) and 3' (3'E(kappa)) enhancers are both quantitatively important to, but not essential for, immunoglobulin kappa rearrangement. To determine the functional redundancy between these two enhancers, B cells derived from mutant embryonic stem cells--in which both MiE(kappa) and 3'E(kappa) we...

journal_title：Nature immunology

authors： Inlay M,Alt FW,Baltimore D,Xu Y

更新日期：2002-05-01 00:00:00

abstract：:Regions of the normal arterial intima predisposed to atherosclerosis are sites of ongoing monocyte trafficking and also contain resident myeloid cells with features of dendritic cells. However, the pathophysiological roles of these cells are poorly understood. Here we found that intimal myeloid cells underwent reverse...

journal_title：Nature immunology

authors： Roufaiel M,Gracey E,Siu A,Zhu SN,Lau A,Ibrahim H,Althagafi M,Tai K,Hyduk SJ,Cybulsky KO,Ensan S,Li A,Besla R,Becker HM,Xiao H,Luther SA,Inman RD,Robbins CS,Jongstra-Bilen J,Cybulsky MI

更新日期：2016-11-01 00:00:00

abstract：:Vaccines against important enteric pathogens such as rotavirus and poliovirus have shown lower efficacy in some populations. The application of new technologies and diverse scientific disciplines are needed to realize the promise of truly universal and effective solutions to combat those and other enteric diseases. ...

journal_title：Nature immunology

authors： Serazin AC,Shackelton LA,Wilson C,Bhan MK

更新日期：2010-09-01 00:00:00

abstract：:TET proteins oxidize 5-methylcytosine in DNA to 5-hydroxymethylcytosine and other oxidation products. We found that simultaneous deletion of Tet2 and Tet3 in mouse CD4+CD8+ double-positive thymocytes resulted in dysregulated development and proliferation of invariant natural killer T cells (iNKT cells). Tet2-Tet3 doub...

journal_title：Nature immunology

authors： Tsagaratou A,González-Avalos E,Rautio S,Scott-Browne JP,Togher S,Pastor WA,Rothenberg EV,Chavez L,Lähdesmäki H,Rao A

更新日期：2017-01-01 00:00:00

abstract：:The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic insufficiency can imprint permanent T cell dysfunction. We found that TILs accumulated depolarized mitochondria as a res...

journal_title：Nature immunology

authors： Yu YR,Imrichova H,Wang H,Chao T,Xiao Z,Gao M,Rincon-Restrepo M,Franco F,Genolet R,Cheng WC,Jandus C,Coukos G,Jiang YF,Locasale JW,Zippelius A,Liu PS,Tang L,Bock C,Vannini N,Ho PC

更新日期：2020-12-01 00:00:00

abstract：:Human CD4+ T cells that produce interleukin 22 are an essential component of skin defense and repair. New evidence shows that these T cells recognize CD1a-lipid complexes on Langerhans cells. ...

journal_title：Nature immunology

authors： Colonna M

更新日期：2010-12-01 00:00:00

abstract：:Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was ...

journal_title：Nature immunology

authors： A-Gonzalez N,Guillen JA,Gallardo G,Diaz M,de la Rosa JV,Hernandez IH,Casanova-Acebes M,Lopez F,Tabraue C,Beceiro S,Hong C,Lara PC,Andujar M,Arai S,Miyazaki T,Li S,Corbi AL,Tontonoz P,Hidalgo A,Castrillo A

更新日期：2013-08-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) of the ILC22 type protect the intestinal mucosa from infection by secreting interleukin 22 (IL-22). ILC22 cells include NKp46(+) and lymphoid tissue-inducer (LTi)-like subsets that express the aryl hydrocarbon receptor (AHR). Here we found that Ahr(-/-) mice had a considerable deficit in I...

journal_title：Nature immunology

authors： Lee JS,Cella M,McDonald KG,Garlanda C,Kennedy GD,Nukaya M,Mantovani A,Kopan R,Bradfield CA,Newberry RD,Colonna M

更新日期：2011-11-20 00:00:00

abstract：:The ST2L receptor for interleukin 33 (IL-33) mediates pulmonary inflammation and immune system-related disorders, such as asthma and rheumatoid arthritis. At present, very little is known about the molecular regulation of ST2L expression. Here we found that FBXL19, an 'orphan' member of the Skp1-Cullin-F-box family of...

journal_title：Nature immunology

authors： Zhao J,Wei J,Mialki RK,Mallampalli DF,Chen BB,Coon T,Zou C,Mallampalli RK,Zhao Y

更新日期：2012-06-03 00:00:00

abstract：:Gadd45beta (growth arrest and DNA damage-inducible, beta) is involved in cell cycle arrest, apoptosis, signal transduction and cell survival. In T cells, Gadd45b was rapidly induced by T cell receptor (TCR) and inflammatory signals. Deficiency of Gadd45beta in CD4+ T cells impaired their responses to TCR stimulation o...

journal_title：Nature immunology

authors： Lu B,Ferrandino AF,Flavell RA

更新日期：2004-01-01 00:00:00

abstract：:HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors SLP-76 and Gads after T cell receptor (TCR) signaling. Here, HPK1 deficiency resulted in enhanced TCR-induced phosphorylation of SLP-76, phospholipase C-gamma1 and the kinase Erk, more-persistent calcium flux, and increased pro...

journal_title：Nature immunology

authors： Shui JW,Boomer JS,Han J,Xu J,Dement GA,Zhou G,Tan TH

更新日期：2007-01-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/ni.3713. ...

journal_title：Nature immunology

authors： Mariño E,Richards JL,McLeod KH,Stanley D,Yap YA,Knight J,McKenzie C,Kranich J,Oliveira AC,Rossello FJ,Krishnamurthy B,Nefzger CM,Macia L,Thorburn A,Baxter AG,Morahan G,Wong LH,Polo JM,Moore RJ,Lockett TJ,Clarke JM

更新日期：2017-10-18 00:00:00

abstract：:The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as an intrinsic negative regulator of Toll-like receptor (TLR)-triggered inflammatory responses. SHP-deficient mice were more susceptible to endotoxi...

journal_title：Nature immunology

authors： Yuk JM,Shin DM,Lee HM,Kim JJ,Kim SW,Jin HS,Yang CS,Park KA,Chanda D,Kim DK,Huang SM,Lee SK,Lee CH,Kim JM,Song CH,Lee SY,Hur GM,Moore DD,Choi HS,Jo EK

更新日期：2011-07-03 00:00:00

abstract：:The Greek island of Crete became host to lively discussions on immunoregulation as experts from around the world gathered for the 7th Aegean Conference on Autoimmunity in September 2015. ...

journal_title：Nature immunology

authors： Walker LS,Ziegler S,Becher B

更新日期：2016-03-01 00:00:00

abstract：:The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found that activation of STAT5 worked together with defects in signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in BLNK,...

journal_title：Nature immunology

authors： Katerndahl CDS,Heltemes-Harris LM,Willette MJL,Henzler CM,Frietze S,Yang R,Schjerven H,Silverstein KAT,Ramsey LB,Hubbard G,Wells AD,Kuiper RP,Scheijen B,van Leeuwen FN,Müschen M,Kornblau SM,Farrar MA

更新日期：2017-06-01 00:00:00

abstract：:Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-beta (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression ...

journal_title：Nature immunology

authors： Karaghiosoff M,Steinborn R,Kovarik P,Kriegshäuser G,Baccarini M,Donabauer B,Reichart U,Kolbe T,Bogdan C,Leanderson T,Levy D,Decker T,Müller M

更新日期：2003-05-01 00:00:00

abstract：:The maintenance of immunological tolerance requires the deletion of self-reactive T cells in the thymus. The expression of genes encoding tissue-specific antigens (TSAs) by thymic epithelial cells is critical for this process and depends on activity of the transcriptional regulator Aire; however, the molecular mechani...

journal_title：Nature immunology

authors： Waterfield M,Khan IS,Cortez JT,Fan U,Metzger T,Greer A,Fasano K,Martinez-Llordella M,Pollack JL,Erle DJ,Su M,Anderson MS

更新日期：2014-03-01 00:00:00

abstract：:A transgenic reporter mouse strain, which expressed the human CD25 (hCD25) surface marker as a reporter under the control of the pre-T cell receptor alpha(pTalpha) promoter, was used to identify lymphoid precursors that expressed pTalpha intracellularly. The hCD25 reporter marked intra- and extrathymic precursors of l...

journal_title：Nature immunology

authors： Gounari F,Aifantis I,Martin C,Fehling HJ,Hoeflinger S,Leder P,von Boehmer H,Reizis B

更新日期：2002-05-01 00:00:00