Abstract:
:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of genomic and biochemical features, and can, on the basis of recent findings, be distinguished by specific surface molecules. The salient feature of these cells is their ability to inhibit T cell function and thus contribute to the pathogenesis of various diseases. In this Review, we discuss the origin and nature of these cells; their distinctive features; and their biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Veglia F,Perego M,Gabrilovich Ddoi
10.1038/s41590-017-0022-xsubject
Has Abstractpub_date
2018-02-01 00:00:00pages
108-119issue
2eissn
1529-2908issn
1529-2916pii
10.1038/s41590-017-0022-xjournal_volume
19pub_type
杂志文章,评审abstract::Gadd45beta (growth arrest and DNA damage-inducible, beta) is involved in cell cycle arrest, apoptosis, signal transduction and cell survival. In T cells, Gadd45b was rapidly induced by T cell receptor (TCR) and inflammatory signals. Deficiency of Gadd45beta in CD4+ T cells impaired their responses to TCR stimulation o...
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abstract::Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. Here we show that blockade of transcriptional elongation through the mouse T cell receptor-alpha (Tcra) locus suppressed V(alph...
journal_title:Nature immunology
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doi:10.1038/ni1379
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abstract::Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic effector CD8(+) T cells (cytotoxic T lymphoytes (CTLs)). Here we report that signaling via Toll-like receptors (TLRs) induced intrahepatic aggregates of myeloid cells that enabled the population expansion of CTLs (iMATEs: 'intra...
journal_title:Nature immunology
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更新日期:2015-03-01 00:00:00
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更新日期:2002-10-01 00:00:00
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doi:10.1038/ni.2918
更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
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journal_title:Nature immunology
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更新日期:2012-05-20 00:00:00
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更新日期:2011-11-06 00:00:00
abstract:: ...
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更新日期:2019-01-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3588
更新日期:2016-12-01 00:00:00
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更新日期:2002-05-01 00:00:00
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doi:10.1038/ni1073
更新日期:2004-06-01 00:00:00
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journal_title:Nature immunology
pub_type: 评论,新闻
doi:10.1038/ni.2115
更新日期:2011-09-20 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2051
更新日期:2011-06-12 00:00:00
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pub_type: 杂志文章
doi:10.1038/ni.1618
更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:Nature immunology
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更新日期:2010-05-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2004-12-01 00:00:00
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journal_title:Nature immunology
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更新日期:2014-10-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Nature immunology
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更新日期:2014-12-01 00:00:00
abstract:: ...
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