Abstract:
:Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to its greatest benefit. The World Health Organization has identified investigations into the molecular basis of nonspecific vaccine effects as a research priority.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Aaby P,Kollmann TR,Benn CSdoi
10.1038/ni.2961subject
Has Abstractpub_date
2014-10-01 00:00:00pages
895-9issue
10eissn
1529-2908issn
1529-2916pii
ni.2961journal_volume
15pub_type
杂志文章abstract::An important function of receptors that signal through immunoreceptor tyrosine-based activation motifs (ITAMs) is to regulate signaling by heterologous receptors. This review describes mechanisms by which ITAM-associated receptors modulate signaling by Toll-like receptors (TLRs), tumor necrosis factor receptor family ...
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/ni.1661
更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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更新日期:2015-09-01 00:00:00
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doi:10.1038/ni.1663
更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-11-01 00:00:00
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更新日期:2017-05-01 00:00:00
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abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-019-0545-4
更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/ni.3790
更新日期:2017-07-19 00:00:00
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doi:10.1038/ni1025
更新日期:2004-02-01 00:00:00
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更新日期:2004-09-01 00:00:00
abstract:: ...
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更新日期:2003-04-01 00:00:00
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更新日期:2016-09-01 00:00:00