Abstract:
:The antiviral factor APOBEC3G upregulates the expression of ligands for the activating receptor NKG2D via DNA damage induced by the viral protein Vpr in cells infected with human immunodeficiency virus. The virus overcomes greater susceptibility to natural killer cell–mediated lysis by targeting APOBEC3G for degradation.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Croxford JL,Gasser Sdoi
10.1038/ni.2115subject
Has Abstractpub_date
2011-09-20 00:00:00pages
925-7issue
10eissn
1529-2908issn
1529-2916pii
ni.2115journal_volume
12pub_type
评论,新闻abstract::The gammadelta T cells are prevalent in the mucosal epithelia and are postulated to act as 'sentries' for maintaining tissue integrity. What these gammadelta T cells recognize is poorly defined, but given the restricted T cell receptor (TCR) repertoire, the idea that they are selected by self antigens of low complexit...
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