Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity.

abstract：:The molecular mechanisms underlying the differentiation of interleukin 17-producing T helper cells (T(H)-17 cells) are still poorly understood. Here we show that optimal transcription of the gene encoding interleukin 17 (Il17) required a 2-kilobase promoter and at least one conserved noncoding (enhancer) sequence, CNS...

journal_title：Nature immunology

authors： Zhang F,Meng G,Strober W

更新日期：2008-11-01 00:00:00

abstract：:The bidirectional interaction between the immune system and whole-body metabolism has been well recognized for many years. Via effects on adipocytes and hepatocytes, immune cells can modulate whole-body metabolism (in metabolic syndromes such as type 2 diabetes and obesity) and, reciprocally, host nutrition and commen...

journal_title：Nature immunology

authors： Newton R,Priyadharshini B,Turka LA

更新日期：2016-05-19 00:00:00

abstract：:The signaling pathways that regulate B and T lymphocytes are remarkably conserved between humans and mice. However, recent evidence suggests that the pathways regulating natural killer (NK) cell activation may actually differ between these two species. We discuss the controversies in the field and propose that this di...

journal_title：Nature immunology

authors： Colucci F,Di Santo JP,Leibson PJ

更新日期：2002-09-01 00:00:00

abstract：:The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs). We now examine potential functions for 53BP1 in the specific genomic alterations that occur in B lymphocytes. Although 53BP1 was dispensable for V(D)J recombination and somatic hyperm...

journal_title：Nature immunology

authors： Manis JP,Morales JC,Xia Z,Kutok JL,Alt FW,Carpenter PB

更新日期：2004-05-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature immunology

authors： Mastellos DC,Blom AM,Connolly ES,Daha MR,Geisbrecht BV,Ghebrehiwet B,Gros P,Hajishengallis G,Holers VM,Huber-Lang M,Kinoshita T,Mollnes TE,Montgomery RA,Morgan BP,Nilsson B,Pio R,Ricklin D,Risitano AM,Taylor RP,Mant

更新日期：2019-11-01 00:00:00

abstract：:Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in transgenic mice. The structure showed a TCR topology notably different...

journal_title：Nature immunology

authors： Hahn M,Nicholson MJ,Pyrdol J,Wucherpfennig KW

更新日期：2005-05-01 00:00:00

abstract：:It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and pro...

journal_title：Nature immunology

authors： Migueles SA,Laborico AC,Shupert WL,Sabbaghian MS,Rabin R,Hallahan CW,Van Baarle D,Kostense S,Miedema F,McLaughlin M,Ehler L,Metcalf J,Liu S,Connors M

更新日期：2002-11-01 00:00:00

abstract：:Although tissue-resident memory T cells (TRM cells) have been shown to regulate host protection in infectious disorders, their function in inflammatory bowel disease (IBD) remains to be investigated. Here we characterized TRM cells in human IBD and in experimental models of intestinal inflammation. Pro-inflammatory TR...

journal_title：Nature immunology

authors： Zundler S,Becker E,Spocinska M,Slawik M,Parga-Vidal L,Stark R,Wiendl M,Atreya R,Rath T,Leppkes M,Hildner K,López-Posadas R,Lukassen S,Ekici AB,Neufert C,Atreya I,van Gisbergen KPJM,Neurath MF

更新日期：2019-03-01 00:00:00

abstract：:CD4(+) follicular helper T cells (T(FH) cells) are essential for germinal center (GC) responses and long-lived antibody responses. Here we report that naive CD4(+) T cells deficient in the transcription factor Foxp1 'preferentially' differentiated into T(FH) cells, which resulted in substantially enhanced GC and antib...

journal_title：Nature immunology

authors： Wang H,Geng J,Wen X,Bi E,Kossenkov AV,Wolf AI,Tas J,Choi YS,Takata H,Day TJ,Chang LY,Sprout SL,Becker EK,Willen J,Tian L,Wang X,Xiao C,Jiang P,Crotty S,Victora GD,Showe LC,Tucker HO,Erikson J,Hu H

更新日期：2014-07-01 00:00:00

abstract：:Microbial DNA sequences containing unmethylated CpG dinucleotides activate Toll-like receptor 9 (TLR9). We have found that TLR9 is localized to the endoplasmic reticulum (ER) of dendritic cells (DCs) and macrophages. Because there is no precedent for immune receptor signaling in the ER, we investigated how TLR9 is act...

journal_title：Nature immunology

authors： Latz E,Schoenemeyer A,Visintin A,Fitzgerald KA,Monks BG,Knetter CF,Lien E,Nilsen NJ,Espevik T,Golenbock DT

更新日期：2004-02-01 00:00:00

abstract：:Dynamic changes in the expression of transcription factors (TFs) can influence the specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TFs among differentially fated precursor cells suggests additional underlying mechanisms. Here we profiled the genome-wide histone modification...

journal_title：Nature immunology

authors： Yu B,Zhang K,Milner JJ,Toma C,Chen R,Scott-Browne JP,Pereira RM,Crotty S,Chang JT,Pipkin ME,Wang W,Goldrath AW

更新日期：2017-05-01 00:00:00

abstract：:CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. We used mice that were transgenic for one of two human CD46 isoforms that differ in their cytoplasmic domains (termed CD46-1 and CD46-2) to analyze the effect of CD46 stimulation ...

journal_title：Nature immunology

authors： Marie JC,Astier AL,Rivailler P,Rabourdin-Combe C,Wild TF,Horvat B

更新日期：2002-07-01 00:00:00

abstract：:Mycobacterium tuberculosis PtpA, a secreted tyrosine phosphatase essential for tuberculosis pathogenicity, could be an ideal target for a drug against tuberculosis, but its active-site inhibitors lack selectivity over human phosphatases. Here we found that PtpA suppressed innate immunity dependent on pathways of the k...

journal_title：Nature immunology

authors： Wang J,Li BX,Ge PP,Li J,Wang Q,Gao GF,Qiu XB,Liu CH

更新日期：2015-03-01 00:00:00

abstract：:Evidence suggests that regulatory T cells expressing the transcription factor Foxp3 develop extrathymically and intrathymically. Mechanisms of extrathymic induction require further scrutiny, especially as proliferation and/or phenotypic changes of preexisting suppressor cells must be distinguished from true de novo ge...

journal_title：Nature immunology

authors： Kretschmer K,Apostolou I,Hawiger D,Khazaie K,Nussenzweig MC,von Boehmer H

更新日期：2005-12-01 00:00:00

abstract：:Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by inhibiting protein tyrosine phosphatases, H2O2 plays an important role as a secondary messenger in the initiation and amplification of signaling at th...

journal_title：Nature immunology

authors： Reth M

更新日期：2002-12-01 00:00:00

abstract：:In the version of this article initially published, the label (CASP4-C285A-HA) above the second and fifth lanes in the right blot in Fig. 1e is incorrect; the correct label is CASP4-C258A-HA. Also, the two labels at right above the plot in Fig. 6c were switched; the far right label should be 'Co-housed Serpinb1a-/-' (...

journal_title：Nature immunology

authors： Choi YJ,Kim S,Choi Y,Nielsen TB,Yan J,Lu A,Ruan J,Lee HR,Wu H,Spellberg B,Jung JU

更新日期：2019-05-01 00:00:00

abstract：:The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-posit...

journal_title：Nature immunology

authors： Bischoff V,Vignal C,Boneca IG,Michel T,Hoffmann JA,Royet J

更新日期：2004-11-01 00:00:00

abstract：:Most antigenic peptides presented by major histocompatibility complex (MHC) class I molecules are produced by the proteasome. Here we show that a proteasome-independent peptide derived from the human tumor protein MAGE-A3 is produced directly by insulin-degrading enzyme (IDE), a cytosolic metallopeptidase. Cytotoxic T...

journal_title：Nature immunology

authors： Parmentier N,Stroobant V,Colau D,de Diesbach P,Morel S,Chapiro J,van Endert P,Van den Eynde BJ

更新日期：2010-05-01 00:00:00

abstract：:In the version of this article initially published, the Supplementary Note was missing. The Supplementary Note has now been provided online and is cited in the Methods section of the article. The error has been corrected in the HTML and PDF version of the article. ...

journal_title：Nature immunology

authors： Zemmour D,Zilionis R,Kiner E,Klein AM,Mathis D,Benoist C

更新日期：2018-06-01 00:00:00

abstract：:Phagocytosis has essential functions in immunity. Here we highlight the presence of a subcellular level of self-non-self discrimination in dendritic cells that operates at the level of individual phagosomes. We discuss how engagement of Toll-like receptor signaling controls distinct programs of phagosome maturation. A...

journal_title：Nature immunology

authors： Blander JM,Medzhitov R

更新日期：2006-10-01 00:00:00

abstract：:Ebola virus is a highly virulent pathogen capable of inducing a frequently lethal hemorrhagic fever syndrome. Accumulating evidence indicates that the virus actively subverts both innate and adaptive immune responses and triggers harmful inflammatory responses as it inflicts direct tissue damage. The host immune syste...

journal_title：Nature immunology

authors： Zampieri CA,Sullivan NJ,Nabel GJ

更新日期：2007-11-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Soveg F,von Moltke J,Savan R

更新日期：2019-02-01 00:00:00

abstract：:Induction of the transcriptional repressor Bcl-6 in CD4(+) T cells is critical for the differentiation of follicular helper T cells (T(FH) cells), which are essential for B cell-mediated immunity. In contrast, the transcription factor Blimp1 (encoded by Prdm1) inhibits T(FH) differentiation by antagonizing Bcl-6. Here...

journal_title：Nature immunology

authors： Xu L,Cao Y,Xie Z,Huang Q,Bai Q,Yang X,He R,Hao Y,Wang H,Zhao T,Fan Z,Qin A,Ye J,Zhou X,Ye L,Wu Y

更新日期：2015-09-01 00:00:00

abstract：:Genes and pathways in which inactivation dampens tissue inflammation present new opportunities for understanding the pathogenesis of common human inflammatory diseases, including inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis. We identified a mutation in the gene encoding the deubiquitination ...

journal_title：Nature immunology

authors： Torre S,Polyak MJ,Langlais D,Fodil N,Kennedy JM,Radovanovic I,Berghout J,Leiva-Torres GA,Krawczyk CM,Ilangumaran S,Mossman K,Liang C,Knobeloch KP,Healy LM,Antel J,Arbour N,Prat A,Majewski J,Lathrop M,Vidal SM,Gros

更新日期：2017-01-01 00:00:00

abstract：:The maintenance of immunological tolerance requires the deletion of self-reactive T cells in the thymus. The expression of genes encoding tissue-specific antigens (TSAs) by thymic epithelial cells is critical for this process and depends on activity of the transcriptional regulator Aire; however, the molecular mechani...

journal_title：Nature immunology

authors： Waterfield M,Khan IS,Cortez JT,Fan U,Metzger T,Greer A,Fasano K,Martinez-Llordella M,Pollack JL,Erle DJ,Su M,Anderson MS

更新日期：2014-03-01 00:00:00

abstract：:The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell b...

journal_title：Nature immunology

authors： Dustin ML,Cooper JA

更新日期：2000-07-01 00:00:00

abstract：:Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed c...

journal_title：Nature immunology

authors： Han J,Zhong CQ,Zhang DW

更新日期：2011-11-16 00:00:00

abstract：:The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors, whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of m...

journal_title：Nature immunology

authors： Zhu C,Chen W,Lou J,Rittase W,Li K

更新日期：2019-10-01 00:00:00

abstract：:CD4(+) T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (T(H)1) or T(H)2 lineages and instead favor the idea of a d...

journal_title：Nature immunology

authors： Harrington LE,Hatton RD,Mangan PR,Turner H,Murphy TL,Murphy KM,Weaver CT

更新日期：2005-11-01 00:00:00

abstract：:While a number of extrinsic factors are known to promote the survival of plasma cells (PCs), the signaling intermediates involved remain poorly characterized. Here we identified inducible nitric oxide synthase (iNOS) as an intermediate that supported the survival of PCs. PCs deficient in iNOS (Nos2(-/-) PCs) showed en...

journal_title：Nature immunology

authors： Saini AS,Shenoy GN,Rath S,Bal V,George A

更新日期：2014-03-01 00:00:00