Abstract:
:The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell biology and immunology studies to explain the role of the actin cytoskeleton in creating the molecular basis for immunological synapse formation and T cell signaling.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Dustin ML,Cooper JAdoi
10.1038/76877keywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
23-9issue
1eissn
1529-2908issn
1529-2916journal_volume
1pub_type
杂志文章,评审abstract::In the steady state, dendritic cells (DCs) in the lymph node induce T cell tolerance to self antigens. Innate signals trigger the maturation of tissue DCs, which migrate into lymph nodes and activate T cells. To examine DCs in vivo, we produced transgenic mice whose DCs expressed enhanced yellow fluorescent protein. T...
journal_title:Nature immunology
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1957
更新日期:2010-12-01 00:00:00
abstract::The ST2L receptor for interleukin 33 (IL-33) mediates pulmonary inflammation and immune system-related disorders, such as asthma and rheumatoid arthritis. At present, very little is known about the molecular regulation of ST2L expression. Here we found that FBXL19, an 'orphan' member of the Skp1-Cullin-F-box family of...
journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2012-06-03 00:00:00
abstract::Hematopoietic stem and progenitor cells (HSPCs) are regulated by various bone marrow stromal cell types. Here we identified rare activated bone marrow monocytes and macrophages with high expression of α-smooth muscle actin (α-SMA) and the cyclooxygenase COX-2 that were adjacent to primitive HSPCs. These myeloid cells ...
journal_title:Nature immunology
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更新日期:2012-11-01 00:00:00
abstract::Foxp3+ regulatory T cells (Treg cells) are the central component of peripheral immune tolerance. Whereas a dysregulated Treg cytokine signature has been observed in autoimmune diseases, the regulatory mechanisms underlying pro- and anti-inflammatory cytokine production are elusive. Here, we identify an imbalance betwe...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0236-6
更新日期:2018-12-01 00:00:00
abstract::We evaluated changes in the signaling potentials and proliferative capacity of single antigen-specific T helper (TH) cells during a primary immune response to a protein antigen. At the peak of cellular expansion in vivo all antigen-specific TH cells exhibited a profound block in CD3- and CD4-mediated mobilization of i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/80841
更新日期:2000-11-01 00:00:00
abstract::Deletion of the DNA-binding domain of the transcription factor Ikaros generates dominant-negative isoforms that interfere with its activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemia (B-ALL). Here we found that conditional inactivation of the Ikaros DNA-binding domain in e...
journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2022
更新日期:2011-05-01 00:00:00
abstract::Caspases are important for apoptosis but are also involved in mammalian cell survival and cell division. Here we report that caspase-3 is a negative regulator of B cell cycling. Mice deficient in caspase-3 (Casp3-/- mice) have increased numbers of splenic B cells that show normal apoptosis but enhanced proliferation i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni976
更新日期:2003-10-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni742
更新日期:2002-01-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1318
更新日期:2006-04-01 00:00:00
abstract::Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3227
更新日期:2015-09-01 00:00:00
abstract::CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells. Here, we focus on viral inter...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1102-1019
更新日期:2002-11-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3257
更新日期:2015-10-01 00:00:00
abstract::In addition to the conventional innate and acquired immune responses, complex organisms have evolved an array of dominant, constitutively expressed genes that suppress or prevent viral infections. Two major cellular defenses against infection by retroviruses are the Fv1 and TRIM5 class of inhibitors that target incomi...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1125
更新日期:2004-11-01 00:00:00
abstract::High-dose radiation activates caspases in tumor cells to produce abundant DNA fragments for DNA sensing in antigen-presenting cells, but the intrinsic DNA sensing in tumor cells after radiation is rather limited. Here we demonstrate that irradiated tumor cells hijack caspase 9 signaling to suppress intrinsic DNA sensi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0641-5
更新日期:2020-05-01 00:00:00
abstract::During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists in B cells. Here we identified a speciali...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3543
更新日期:2016-10-01 00:00:00
abstract::The transcription factor BATF directly regulates key components of the formation and function of follicular helper T cells and antibody class switching in B cells. ...
journal_title:Nature immunology
pub_type: 评论,新闻
doi:10.1038/ni.2042
更新日期:2011-06-01 00:00:00
abstract::Genes and pathways in which inactivation dampens tissue inflammation present new opportunities for understanding the pathogenesis of common human inflammatory diseases, including inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis. We identified a mutation in the gene encoding the deubiquitination ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3581
更新日期:2017-01-01 00:00:00
abstract::The importance of protein glycosylation in the migration of immune cells throughout the body has been extensively appreciated. However, our awareness of the impact of glycosylation on the regulation of innate and adaptive immune responses is relatively new. An increasing number of studies reveal the relevance of glyco...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.f.203
更新日期:2008-06-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2622
更新日期:2013-08-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.1937
更新日期:2010-10-01 00:00:00
abstract::The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoi...
journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1550
更新日期:2008-01-01 00:00:00
abstract::Newly activated CD8(+) T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals that mediate metabolic reprogramming remain poorly defined. Here we demonstrate an essential role for sterol regulatory element-binding proteins (SREBPs) in the acquisition...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2570
更新日期:2013-05-01 00:00:00
abstract::The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated T cells in the lymph node may be crucial in early HIV-1 pathogenesis. We have characterized primary DCs for the receptors involved in viral envelope attachment and observed that C-type lectin receptor (CLR) binding was p...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni841
更新日期:2002-10-01 00:00:00
abstract::Despite accumulating evidence that regulatory T cells play a crucial role in preventing autoimmunity, the processes underlying their generation during immune repertoire formation are unknown. We show here that interactions with a single self-peptide can induce thymocytes that bear an autoreactive T cell receptor (TCR)...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/86302
更新日期:2001-04-01 00:00:00
abstract::Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonst...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1983
更新日期:2011-02-01 00:00:00
abstract::Myelin basic protein-specific CD8(+) T cells can induce central nervous system autoimmunity; however, immune tolerance prevents these autoreactive cells from causing disease. To define the mechanisms that mediate tolerance, we developed two T cell receptor-transgenic mouse lines with different affinities for the H-2K(...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1073
更新日期:2004-06-01 00:00:00
abstract::Susceptibility to complex autoimmune diseases (AIDs) is a multigenic phenotype affected by a variety of genetic and environmental or stochastic factors. After over a decade of linkage analyses, the identification of non-major histocompatibility complex (non-MHC) susceptibility alleles has proved to be difficult, predo...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni0901-802
更新日期:2001-09-01 00:00:00