Abstract:
:Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonstrated that although the T(H)2 polarization of ECM1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs. This was associated with reduced expression of KLF2 and S1P(1). We also found that ECM1 could directly bind the interleukin-2 (IL-2) receptor to inhibit IL-2 signaling and activate S1P(1) expression. Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Li Z,Zhang Y,Liu Z,Wu X,Zheng Y,Tao Z,Mao K,Wang J,Lin G,Tian L,Ji Y,Qin M,Sun S,Zhu X,Sun Bdoi
10.1038/ni.1983subject
Has Abstractpub_date
2011-02-01 00:00:00pages
178-85issue
2eissn
1529-2908issn
1529-2916pii
ni.1983journal_volume
12pub_type
杂志文章abstract::CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells. Here, we focus on viral inter...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1102-1019
更新日期:2002-11-01 00:00:00
abstract::Hematopoiesis requires tight regulation of the hematopoietic stem cell (HSC) population; however, the dynamics of HSC use at steady state are uncertain. Over 3-7 months, we evaluated the repopulation and self-renewal of more than 600 individual human 'severe combined immunodeficiency mouse-repopulating cells' (SRCs), ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1393
更新日期:2006-11-01 00:00:00
abstract::The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1957
更新日期:2010-12-01 00:00:00
abstract::This corrects the article DOI: 10.1038/ni.3713. ...
journal_title:Nature immunology
pub_type: 杂志文章,已发布勘误
doi:10.1038/ni1117-1271c
更新日期:2017-10-18 00:00:00
abstract::Although master transcription factors (TFs) are key to the development of specific T cell subsets, whether additional transcriptional regulators are induced by the same stimuli that dominantly repress the development of other, non-specific T cell lineages has not been fully elucidated. Through the use of regulatory T ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3667
更新日期:2017-03-01 00:00:00
abstract::The Greek island of Crete became host to lively discussions on immunoregulation as experts from around the world gathered for the 7th Aegean Conference on Autoimmunity in September 2015. ...
journal_title:Nature immunology
pub_type:
doi:10.1038/ni.3367
更新日期:2016-03-01 00:00:00
abstract::Diverse cellular responses to external cues are controlled by a small number of signal-transduction pathways, but how the specificity of functional outcomes is achieved remains unclear. Here we describe a mechanism for signal integration based on the functional coupling of two distinct signaling pathways widely used i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2845
更新日期:2014-04-01 00:00:00
abstract::Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear. Here, we show that the transcription fact...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0737-y
更新日期:2020-09-01 00:00:00
abstract::T cells compete in the response to antigen in vivo and this competition may drive the affinity maturation of a secondary T cell response. Here we show that high-affinity T cells out-competed lower affinity T cells during a response to antigenic challenge in vivo. Although competition between T cells specific for diffe...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni742
更新日期:2002-01-01 00:00:00
abstract::DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on myeloid cells and natural killer cells. We examine here the responses of mice lacking DAP12 to stimulation through Toll-like receptors (TLRs). Unexpectedly, DAP12-deficient macrophages produced...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1204
更新日期:2005-06-01 00:00:00
abstract::Feedback regulatory circuits provided by regulatory T cells (T(reg) cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of path...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2406
更新日期:2012-10-01 00:00:00
abstract::Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2961
更新日期:2014-10-01 00:00:00
abstract::As a result of decades of research-driven breakthroughs in basic and clinical science and recent advances in the broad-scale implementation of interventions for the prevention and treatment of infection with HIV, a turning point has been reached in the global HIV-AIDS pandemic. To end the pandemic and achieve the goal...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2735
更新日期:2013-11-01 00:00:00
abstract::Naturally arising CD25(+)CD4(+) regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their antigen-specific population expansion can establish ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1178
更新日期:2005-04-01 00:00:00
abstract::After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putati...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2536
更新日期:2013-04-01 00:00:00
abstract::Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. Here we show that blockade of transcriptional elongation through the mouse T cell receptor-alpha (Tcra) locus suppressed V(alph...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1379
更新日期:2006-10-01 00:00:00
abstract::The signaling pathways that regulate B and T lymphocytes are remarkably conserved between humans and mice. However, recent evidence suggests that the pathways regulating natural killer (NK) cell activation may actually differ between these two species. We discuss the controversies in the field and propose that this di...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni0902-807
更新日期:2002-09-01 00:00:00
abstract::The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1017
更新日期:2004-01-01 00:00:00
abstract::Neutrophils encounter and 'prioritize' many chemoattractants in their pursuit of bacteria. Here we tested the possibility that the phosphatase PTEN is responsible for the prioritization of chemoattractants. Neutrophils induced chemotaxis by two separate pathways, the phosphatidylinositol-3-OH kinase (PI(3)K) phosphata...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1623
更新日期:2008-07-01 00:00:00
abstract::CRACM1 (also called Orai1) constitutes the pore subunit of store-operated calcium release-activated calcium channels. A point mutation in the gene encoding CRACM1 is associated with severe combined immunodeficiency disease in humans. Here we generated CRACM1-deficient mice in which beta-galactosidase activity 'reporte...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1550
更新日期:2008-01-01 00:00:00
abstract::Foxp3+ regulatory T cells (Treg cells) are the central component of peripheral immune tolerance. Whereas a dysregulated Treg cytokine signature has been observed in autoimmune diseases, the regulatory mechanisms underlying pro- and anti-inflammatory cytokine production are elusive. Here, we identify an imbalance betwe...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0236-6
更新日期:2018-12-01 00:00:00
abstract::Immunologists are being compelled to develop new high-dimensional perspectives of cellular heterogeneity and to determine which applications best exploit the power of mass cytometry and associated multiplex approaches. ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.3485
更新日期:2016-07-19 00:00:00
abstract::Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic effector CD8(+) T cells (cytotoxic T lymphoytes (CTLs)). Here we report that signaling via Toll-like receptors (TLRs) induced intrahepatic aggregates of myeloid cells that enabled the population expansion of CTLs (iMATEs: 'intra...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2573
更新日期:2013-06-01 00:00:00
abstract::The cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the parenchyma. T cells deficient in sphingosine 1-phosphate receptor ty...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1682
更新日期:2009-01-01 00:00:00
abstract:: ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0247-3
更新日期:2018-11-01 00:00:00
abstract::While a number of extrinsic factors are known to promote the survival of plasma cells (PCs), the signaling intermediates involved remain poorly characterized. Here we identified inducible nitric oxide synthase (iNOS) as an intermediate that supported the survival of PCs. PCs deficient in iNOS (Nos2(-/-) PCs) showed en...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2806
更新日期:2014-03-01 00:00:00
abstract::Transcriptome profiling is widely used to infer functional states of specific cell types, as well as their responses to stimuli, to define contributions to physiology and pathophysiology. Focusing on microglia, the brain's macrophages, we report here a side-by-side comparison of classical cell-sorting-based transcript...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0110-6
更新日期:2018-06-01 00:00:00
abstract::Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-complex adaptor, binds and stabilizes mRNAs encoding key inflammatory proteins. The Act1 SEFIR domain binds a stem-loop structure, the SEFIR-bind...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0071-9
更新日期:2018-04-01 00:00:00
abstract::More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight expectations in this dynamic field. ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1009-1039
更新日期:2009-10-01 00:00:00
abstract::Group 2 innate lymphoid cells (ILC2s) and CD4+ type 2 helper T cells (TH2 cells) are defined by their similar effector cytokines, which together mediate the features of allergic immunity. We found that tissue ILC2s and TH2 cells differentiated independently but shared overlapping effector function programs that were m...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3582
更新日期:2016-12-01 00:00:00