Abstract：
:CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells. Here, we focus on viral interference with antigen presentation; in particular we consider the importance (and difficulty) of establishing the evolutionary significance (that is, the ability to enhance viral transmission) of viral gene products that interfere with antigen presentation in vitro.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Yewdell JW,Hill ABdoi
10.1038/ni1102-1019keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1019-25issue
11eissn
1529-2908issn
1529-2916pii
ni1102-1019journal_volume
3pub_type
杂志文章,评审abstract：:An important function of receptors that signal through immunoreceptor tyrosine-based activation motifs (ITAMs) is to regulate signaling by heterologous receptors. This review describes mechanisms by which ITAM-associated receptors modulate signaling by Toll-like receptors (TLRs), tumor necrosis factor receptor family ...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.1706
更新日期：2009-04-01 00:00:00
abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of ...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/s41590-017-0022-x
更新日期：2018-02-01 00:00:00
abstract：:Dynamic changes in the expression of transcription factors (TFs) can influence the specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TFs among differentially fated precursor cells suggests additional underlying mechanisms. Here we profiled the genome-wide histone modification...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3706
更新日期：2017-05-01 00:00:00
abstract：:Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-beta (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni910
更新日期：2003-05-01 00:00:00
abstract：:The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A. The structure shows a tightly fit lipid in the CD1d binding groove, with the sp...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1225
更新日期：2005-08-01 00:00:00
abstract：:Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptive immunity. Although intense effort has been devoted to studying the regulation and requirements...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni1201-1103
更新日期：2001-12-01 00:00:00
abstract：:Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune response. Using small interfering RNA, we show here that dynamin 2 (Dyn2), a large GTPase involved in receptor-mediated internalization, did not alter antibody-mediated T cell receptor internalizat...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1168
更新日期：2005-03-01 00:00:00
abstract：:Notch molecules are well conserved from Drosophila melanogaster to mammals and regulate a broad spectrum of various cell lineage commitment processes. Recent studies using inhibitors, transgenic mice and conditional loss-of-function approaches have demonstrated essential roles for Notch signaling in the differentiatio...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni1453
更新日期：2007-05-01 00:00:00
abstract：:Mice deficient in the adaptor Ndfip1 develop inflammation at sites of environmental antigen exposure. We show here that such mice had fewer inducible regulatory T cells (iT(reg) cells). In vitro, Ndfip1-deficient T cells expressed normal amounts of the transcription factor Foxp3 during the first 48 h of iT(reg) cell d...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2154
更新日期：2011-11-13 00:00:00
abstract：:Polarization of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell (APC) is driven by the accumulation of diacylglycerol (DAG) at the immunological synapse (IS). The mechanisms that couple DAG to the MTOC are not known. By single-cell photoactivation of the T cell antigen receptor (TCR)...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2033
更新日期：2011-05-22 00:00:00
abstract：:The prevalence of autoimmune disorders in affluent countries has reached epidemic proportions. Over the past 50 years, a reverse trend between the frequency of infectious diseases and the incidence of autoimmune and allergic diseases led to the so-called 'hygiene hypothesis'. Given the epidemiological evidence and rec...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3851
更新日期：2017-10-18 00:00:00
abstract：: ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-018-0309-6
更新日期：2019-02-01 00:00:00
abstract：:Phagocytosis has essential functions in immunity. Here we highlight the presence of a subcellular level of self-non-self discrimination in dendritic cells that operates at the level of individual phagosomes. We discuss how engagement of Toll-like receptor signaling controls distinct programs of phagosome maturation. A...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni1006-1029
更新日期：2006-10-01 00:00:00
abstract：:Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestra...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.1937
更新日期：2010-10-01 00:00:00
abstract：:The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as an intrinsic negative regulator of Toll-like receptor (TLR)-triggered inflammatory responses. SHP-deficient mice were more susceptible to endotoxi...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2064
更新日期：2011-07-03 00:00:00
abstract：:The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we iden...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1085
更新日期：2004-07-01 00:00:00
abstract：:After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putati...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2536
更新日期：2013-04-01 00:00:00
abstract：:The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1017
更新日期：2004-01-01 00:00:00
abstract：:T cells compete in the response to antigen in vivo and this competition may drive the affinity maturation of a secondary T cell response. Here we show that high-affinity T cells out-competed lower affinity T cells during a response to antigenic challenge in vivo. Although competition between T cells specific for diffe...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni742
更新日期：2002-01-01 00:00:00
abstract：:The autoimmune regulator Aire is expressed in a small proportion of medullary thymic epithelial cells (mTECs) and is crucial in the induction of central T cell tolerance. The origin and development of Aire(+) mTECs, however, are not well understood. Here we demonstrate that the tight-junction components claudin-3 and ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1438
更新日期：2007-03-01 00:00:00
abstract：:The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen-specific defense reactions through selective activation of the Toll and the immune deficiency (Imd) signaling pathways. The Toll pathway mediates most defenses against Gram-positive bacteria and fungi...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni922
更新日期：2003-05-01 00:00:00
abstract：:Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we show that in interferon-γ-stimulated cells guanylate-binding pro...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-0697-2
更新日期：2020-08-01 00:00:00
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journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-019-0582-z
更新日期：2020-02-01 00:00:00
abstract：: ...
journal_title：Nature immunology
pub_type： 评论,杂志文章
doi：10.1038/s41590-018-0302-0
更新日期：2019-02-01 00:00:00
abstract：:Chemoattractant-stimulated granule release from neutrophils, basophils and eosinophils is critical for the innate immune response against infectious bacteria. Interleukin 8 (IL-8) activation of the chemokine receptor CXCRI was found to stimulate rapid formation of beta-arrestin complexes with Hck or c-Fgr. Formation o...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/79767
更新日期：2000-09-01 00:00:00
abstract：:The gammadelta T cells are prevalent in the mucosal epithelia and are postulated to act as 'sentries' for maintaining tissue integrity. What these gammadelta T cells recognize is poorly defined, but given the restricted T cell receptor (TCR) repertoire, the idea that they are selected by self antigens of low complexit...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1267
更新日期：2005-12-01 00:00:00
abstract：:In the version of this article initially published, the Supplementary Note was missing. The Supplementary Note has now been provided online and is cited in the Methods section of the article. The error has been corrected in the HTML and PDF version of the article. ...
journal_title：Nature immunology
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41590-018-0104-4
更新日期：2018-06-01 00:00:00
abstract：:Group 2 innate lymphoid cells (ILC2s) and CD4+ type 2 helper T cells (TH2 cells) are defined by their similar effector cytokines, which together mediate the features of allergic immunity. We found that tissue ILC2s and TH2 cells differentiated independently but shared overlapping effector function programs that were m...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3582
更新日期：2016-12-01 00:00:00
abstract：:The transcription factor Aire controls immunological tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire's specificity, we performed single-cell RNA-seq and DNA-methylation analysis of Aire-suffi...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3247
更新日期：2015-09-01 00:00:00
abstract：:Ingested antigens lead to the generation of effector T cells that secrete interleukin 4 (IL-4) rather than interferon-gamma (IFN-gamma) and are capable of influencing naive T cells in their immediate environment to do the same. Using chimeric mice generated by aggregation of two genotypically different embryos, we fou...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1077
更新日期：2004-06-01 00:00:00
