Abstract:
:Ingested antigens lead to the generation of effector T cells that secrete interleukin 4 (IL-4) rather than interferon-gamma (IFN-gamma) and are capable of influencing naive T cells in their immediate environment to do the same. Using chimeric mice generated by aggregation of two genotypically different embryos, we found that the conversion of a naive T cell occurs only if it can interact with the same antigen-presenting cell, although not necessarily the same antigen, as the effector T cell. Using a two-step culture system in vitro, we found that antigen-presenting dendritic cells can act as 'temporal bridges' to relay information from orally immunized memory CD4 T cells to naive CD4 T cells. The orally immunized T cells use IL-4 and IL-10 (but not CD40 ligand) to 'educate' dendritic cells, which in turn induce naive T cells to produce the same cytokines as those produced by the orally immunized memory T cells.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Alpan O,Bachelder E,Isil E,Arnheiter H,Matzinger Pdoi
10.1038/ni1077keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
615-22issue
6eissn
1529-2908issn
1529-2916pii
ni1077journal_volume
5pub_type
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