Abstract：
:The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regulation of apoptosis. Intracellular OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (sOPN) increase the population size of lymphoid cells. The total effect of OPN on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis. Our study suggests previously unknown detrimental roles for two OPN isoforms in causing the imbalance of leukocyte populations.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Kanayama M,Xu S,Danzaki K,Gibson JR,Inoue M,Gregory SG,Shinohara MLdoi
10.1038/ni.3791subject
Has Abstractpub_date
2017-09-01 00:00:00pages
973-984issue
9eissn
1529-2908issn
1529-2916pii
ni.3791journal_volume
18pub_type
杂志文章abstract：:After homing to lymph nodes, CD8+ T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinet...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1559
更新日期：2008-03-01 00:00:00
abstract：:Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. Here we show that blockade of transcriptional elongation through the mouse T cell receptor-alpha (Tcra) locus suppressed V(alph...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1379
更新日期：2006-10-01 00:00:00
abstract：:Infection of erythrocytes with Plasmodium species induces clinical malaria. Parasite-specific CD4(+) T cells correlate with lower parasite burdens and severity of human malaria and are needed to control blood-stage infection in mice. However, the characteristics of CD4(+) T cells that determine protection or parasite ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2180
更新日期：2011-12-11 00:00:00
abstract：:CD8(+) T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of antiviral cytokines. Here we identify the following additional function for memory CD8(+) T cells that persist at front-line sites of microbial exposure: to serve as local sensors of previousl...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2568
更新日期：2013-05-01 00:00:00
abstract：:Nedd4 and Itch are E3 ubiquitin ligases that ubiquitinate similar targets in vitro and thus are thought to function similarly. T cells lacking Itch show spontaneous activation and T helper type 2 polarization. To test whether loss of Nedd4 affects T cells in the same way, we generated Nedd4(+/+) and Nedd4(-/-) fetal l...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1670
更新日期：2008-12-01 00:00:00
abstract：:The transcription factor BATF directly regulates key components of the formation and function of follicular helper T cells and antibody class switching in B cells. ...
journal_title：Nature immunology
pub_type： 评论,新闻
doi：10.1038/ni.2042
更新日期：2011-06-01 00:00:00
abstract：:HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors SLP-76 and Gads after T cell receptor (TCR) signaling. Here, HPK1 deficiency resulted in enhanced TCR-induced phosphorylation of SLP-76, phospholipase C-gamma1 and the kinase Erk, more-persistent calcium flux, and increased pro...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1416
更新日期：2007-01-01 00:00:00
abstract：:Intestinal microfold cells (M cells) are an enigmatic lineage of intestinal epithelial cells that initiate mucosal immune responses through the uptake and transcytosis of luminal antigens. The mechanisms of M-cell differentiation are poorly understood, as the rarity of these cells has hampered analysis. Exogenous admi...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2352
更新日期：2012-06-17 00:00:00
abstract：:Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3227
更新日期：2015-09-01 00:00:00
abstract：: ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-018-0309-6
更新日期：2019-02-01 00:00:00
abstract：:Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved unders...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2343
更新日期：2012-07-19 00:00:00
abstract：:Recent studies have highlighted the structural requirements for T cell costimulation and have revealed unusual modes of dimerization for the cytolytic T lymphocyte-associated antigen 4 (CTLA-4) costimulatory receptor and its B7 ligands. These distinctive quaternary structures potentially endow both receptor and ligand...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni0502-427
更新日期：2002-05-01 00:00:00
abstract：:Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These st...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni1116
更新日期：2004-10-01 00:00:00
abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of ...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/s41590-017-0022-x
更新日期：2018-02-01 00:00:00
abstract：:The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found that activation of STAT5 worked together with defects in signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in BLNK,...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3716
更新日期：2017-06-01 00:00:00
abstract：:Toxoplasma gondii is a common protozoan parasite that infects up to one third of the world's population. Notably, very little is known about innate immune sensing mechanisms for this obligate intracellular parasite by human cells. Here, by applying an unbiased biochemical screening approach, we show that human monocyt...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-018-0250-8
更新日期：2019-01-01 00:00:00
abstract：:Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we show that in interferon-γ-stimulated cells guanylate-binding pro...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-0697-2
更新日期：2020-08-01 00:00:00
abstract：:Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic effector CD8(+) T cells (cytotoxic T lymphoytes (CTLs)). Here we report that signaling via Toll-like receptors (TLRs) induced intrahepatic aggregates of myeloid cells that enabled the population expansion of CTLs (iMATEs: 'intra...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2573
更新日期：2013-06-01 00:00:00
abstract：:We evaluated changes in the signaling potentials and proliferative capacity of single antigen-specific T helper (TH) cells during a primary immune response to a protein antigen. At the peak of cellular expansion in vivo all antigen-specific TH cells exhibited a profound block in CD3- and CD4-mediated mobilization of i...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/80841
更新日期：2000-11-01 00:00:00
abstract：:Gadd45beta (growth arrest and DNA damage-inducible, beta) is involved in cell cycle arrest, apoptosis, signal transduction and cell survival. In T cells, Gadd45b was rapidly induced by T cell receptor (TCR) and inflammatory signals. Deficiency of Gadd45beta in CD4+ T cells impaired their responses to TCR stimulation o...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1020
更新日期：2004-01-01 00:00:00
abstract：:The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte assembles a unique VLR by rearrangement of the germline gene. In the lamprey genome, we identify here about 850 distinct cassettes encoding leucine-ri...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1463
更新日期：2007-06-01 00:00:00
abstract：:The molecular mechanisms underlying the differentiation of interleukin 17-producing T helper cells (T(H)-17 cells) are still poorly understood. Here we show that optimal transcription of the gene encoding interleukin 17 (Il17) required a 2-kilobase promoter and at least one conserved noncoding (enhancer) sequence, CNS...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1663
更新日期：2008-11-01 00:00:00
abstract：:The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1957
更新日期：2010-12-01 00:00:00
abstract：:A transgenic reporter mouse strain, which expressed the human CD25 (hCD25) surface marker as a reporter under the control of the pre-T cell receptor alpha(pTalpha) promoter, was used to identify lymphoid precursors that expressed pTalpha intracellularly. The hCD25 reporter marked intra- and extrathymic precursors of l...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni778
更新日期：2002-05-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature immunology
pub_type： 已发布勘误
doi：10.1038/s41590-019-0545-4
更新日期：2019-12-01 00:00:00
abstract：:As part of the most important contributions to the understanding of viral immunity, Michael Oldstone recounts his pioneering work on lymphocytic choriomeningitis virus. ...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni0407-325
更新日期：2007-04-01 00:00:00
abstract：:We have identified a silencer and an antisilencing element that interact at a distance of 85 kilobases to regulate expression of the recombination activating genes Rag1 and Rag2 in thymocytes. Transgenic experiments showed that Rag promoter-proximal cis elements directed tissue-specific expression and that a Runx-depe...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1053
更新日期：2004-04-01 00:00:00
abstract：:The kappa intronic (MiE(kappa)) and 3' (3'E(kappa)) enhancers are both quantitatively important to, but not essential for, immunoglobulin kappa rearrangement. To determine the functional redundancy between these two enhancers, B cells derived from mutant embryonic stem cells--in which both MiE(kappa) and 3'E(kappa) we...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni790
更新日期：2002-05-01 00:00:00
abstract：:Neutrophils encounter and 'prioritize' many chemoattractants in their pursuit of bacteria. Here we tested the possibility that the phosphatase PTEN is responsible for the prioritization of chemoattractants. Neutrophils induced chemotaxis by two separate pathways, the phosphatidylinositol-3-OH kinase (PI(3)K) phosphata...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1623
更新日期：2008-07-01 00:00:00
abstract：:The extracellular protein Spätzle is required for activation of the Toll signaling pathway in the embryonic development and innate immune defense of Drosophila. Spätzle is synthesized as a pro-protein and is processed to a functional form by a serine protease. We show here that the mature form of Spätzle triggers a To...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni955
更新日期：2003-08-01 00:00:00
