Author Correction: Mechanosensing through immunoreceptors.

Abstract:

:An amendment to this paper has been published and can be accessed via a link at the top of the paper.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Zhu C,Chen W,Lou J,Rittase W,Li K

doi

10.1038/s41590-019-0545-4

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1700

issue

12

eissn

1529-2908

issn

1529-2916

pii

10.1038/s41590-019-0545-4

journal_volume

20

pub_type

已发布勘误
  • Renaissance for mouse models of human hematopoiesis and immunobiology.

    abstract::More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight expectations in this dynamic field. ...

    journal_title:Nature immunology

    pub_type: 杂志文章,评审

    doi:10.1038/ni1009-1039

    authors: Manz MG,Di Santo JP

    更新日期:2009-10-01 00:00:00

  • Hydrogen peroxide as second messenger in lymphocyte activation.

    abstract::Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by inhibiting protein tyrosine phosphatases, H2O2 plays an important role as a secondary messenger in the initiation and amplification of signaling at th...

    journal_title:Nature immunology

    pub_type: 杂志文章,评审

    doi:10.1038/ni1202-1129

    authors: Reth M

    更新日期:2002-12-01 00:00:00

  • The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination.

    abstract::Although approximately 200 viral microRNAs are known, only very few share similar targets with their host's microRNAs. A notable example of this is the stress-induced ligand MICB, which is targeted by several distinct viral and cellular microRNAs. Through the investigation of the microRNA-mediated immune-evasion strat...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.1916

    authors: Nachmani D,Lankry D,Wolf DG,Mandelboim O

    更新日期:2010-09-01 00:00:00

  • Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity.

    abstract::The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyloid A1 (SAA1), tha...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/s41590-020-0698-1

    authors: Smole U,Gour N,Phelan J,Hofer G,Köhler C,Kratzer B,Tauber PA,Xiao X,Yao N,Dvorak J,Caraballo L,Puerta L,Rosskopf S,Chakir J,Malle E,Lane AP,Pickl WF,Lajoie S,Wills-Karp M

    更新日期:2020-07-01 00:00:00

  • Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.

    abstract::We identified a tumor-associated cytotoxic T lymphocyte (CTL) epitope derived from the widely expressed human MDM2 oncoprotein and were able to bypass self-tolerance to this tumor antigen in HLA-A*0201 (A2.1) transgenic mice and by generating A2.1-negative, allo-A2.1-restricted human T lymphocytes. A broad range of ma...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1001-962

    authors: Stanislawski T,Voss RH,Lotz C,Sadovnikova E,Willemsen RA,Kuball J,Ruppert T,Bolhuis RL,Melief CJ,Huber C,Stauss HJ,Theobald M

    更新日期:2001-10-01 00:00:00

  • Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria.

    abstract::Although the relationship between hematopoietic stem cells and progenitor populations has been investigated extensively under steady-state conditions, the dynamic response of the hematopoietic compartment during acute infection is largely unknown. Here we show that after infection of mice with Plasmodium chabaudi, a c...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.1869

    authors: Belyaev NN,Brown DE,Diaz AI,Rae A,Jarra W,Thompson J,Langhorne J,Potocnik AJ

    更新日期:2010-06-01 00:00:00

  • Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes.

    abstract::CD4+ T cell priming under T helper type I (T(H)1) or T(H)2 conditions gives rise to polarized cytokine gene expression. We found that in these conditions human naive T cells acquired stable histone hyperacetylation at either the Ifng or Il4 promoter. Effector memory T cells showed polarized cytokine gene acetylation p...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni872

    authors: Messi M,Giacchetto I,Nagata K,Lanzavecchia A,Natoli G,Sallusto F

    更新日期:2003-01-01 00:00:00

  • Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis.

    abstract::Regulatory T (Treg) cells respond to immune and inflammatory signals to mediate immunosuppression, but how the functional integrity of Treg cells is maintained under activating environments is unclear. Here we show that autophagy is active in Treg cells and supports their lineage stability and survival fitness. Treg c...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.3365

    authors: Wei J,Long L,Yang K,Guy C,Shrestha S,Chen Z,Wu C,Vogel P,Neale G,Green DR,Chi H

    更新日期:2016-03-01 00:00:00

  • The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

    abstract::Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs. The Itch-Cyld complex sequentially cleaved Lys63-linked ubiquitin chains and...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.2157

    authors: Ahmed N,Zeng M,Sinha I,Polin L,Wei WZ,Rathinam C,Flavell R,Massoumi R,Venuprasad K

    更新日期:2011-11-06 00:00:00

  • Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA.

    abstract::Interferon-γ (IFN-γ) is essential for the innate immune response to intracellular bacteria. Noncoding RNAs and RNA-binding proteins (RBPs) need to be further considered in studies of regulation of the IFN-γ-activated signaling pathway in macrophages. In the present study, we found that the microRNA miR-1 promoted IFN-...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/s41590-019-0542-7

    authors: Xu H,Jiang Y,Xu X,Su X,Liu Y,Ma Y,Zhao Y,Shen Z,Huang B,Cao X

    更新日期:2019-12-01 00:00:00

  • A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.

    abstract::MicroRNAs (miRNAs) exert powerful effects on immunological function by tuning networks of target genes that orchestrate cell activity. We sought to identify miRNAs and miRNA-regulated pathways that control the type 2 helper T cell (TH2 cell) responses that drive pathogenic inflammation in asthma. Profiling miRNA expre...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.3026

    authors: Simpson LJ,Patel S,Bhakta NR,Choy DF,Brightbill HD,Ren X,Wang Y,Pua HH,Baumjohann D,Montoya MM,Panduro M,Remedios KA,Huang X,Fahy JV,Arron JR,Woodruff PG,Ansel KM

    更新日期:2014-12-01 00:00:00

  • Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.

    abstract::Hematopoietic stem and progenitor cells (HSPCs) are regulated by various bone marrow stromal cell types. Here we identified rare activated bone marrow monocytes and macrophages with high expression of α-smooth muscle actin (α-SMA) and the cyclooxygenase COX-2 that were adjacent to primitive HSPCs. These myeloid cells ...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.2408

    authors: Ludin A,Itkin T,Gur-Cohen S,Mildner A,Shezen E,Golan K,Kollet O,Kalinkovich A,Porat Z,D'Uva G,Schajnovitz A,Voronov E,Brenner DA,Apte RN,Jung S,Lapidot T

    更新日期:2012-11-01 00:00:00

  • CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation.

    abstract::CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, which coordinate signaling pathways emanating from the plasma membrane. CARMA1 interacts with Bcl10 via its caspase-recruitment domain (CARD). Here we investigated the role of CARMA1 in T cell act...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni830

    authors: Gaide O,Favier B,Legler DF,Bonnet D,Brissoni B,Valitutti S,Bron C,Tschopp J,Thome M

    更新日期:2002-09-01 00:00:00

  • The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.

    abstract::Autoreactive B cells have critical roles in a large diversity of autoimmune diseases, but the molecular pathways that control these cells remain poorly understood. We performed an in vivo functional screen of a lymphocyte-expressed microRNA library and identified miR-148a as a potent regulator of B cell tolerance. Ele...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.3385

    authors: Gonzalez-Martin A,Adams BD,Lai M,Shepherd J,Salvador-Bernaldez M,Salvador JM,Lu J,Nemazee D,Xiao C

    更新日期:2016-04-01 00:00:00

  • Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance.

    abstract::T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of ...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1321

    authors: Kallies A,Hawkins ED,Belz GT,Metcalf D,Hommel M,Corcoran LM,Hodgkin PD,Nutt SL

    更新日期:2006-05-01 00:00:00

  • A suspenseful game of 'hide and seek' between virus and host.

    abstract::As part of the most important contributions to the understanding of viral immunity, Michael Oldstone recounts his pioneering work on lymphocytic choriomeningitis virus. ...

    journal_title:Nature immunology

    pub_type: 杂志文章,评审

    doi:10.1038/ni0407-325

    authors: Oldstone MB

    更新日期:2007-04-01 00:00:00

  • Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.

    abstract::Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution co...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.2490

    authors: Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB,ImmGen Project Consortium.

    更新日期:2013-01-01 00:00:00

  • Remote control of γc expression by arginine methylation.

    abstract:: ...

    journal_title:Nature immunology

    pub_type: 评论,杂志文章

    doi:10.1038/s41590-018-0240-x

    authors: Park JY,Park JH

    更新日期:2018-11-01 00:00:00

  • The crystal structure of human CD1d with and without alpha-galactosylceramide.

    abstract::The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A. The structure shows a tightly fit lipid in the CD1d binding groove, with the sp...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1225

    authors: Koch M,Stronge VS,Shepherd D,Gadola SD,Mathew B,Ritter G,Fersht AR,Besra GS,Schmidt RR,Jones EY,Cerundolo V

    更新日期:2005-08-01 00:00:00

  • Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation.

    abstract::Antigen receptor-mediated production of inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) in lymphocytes triggers the release of Ca2+ from intracellular stores; this release of Ca2+ results in the opening of store-operated Ca2+ channels in the plasma membrane. Here we report that mice lacking Ins(1,4,5)P3 3-kinase B (Itpkb)...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni1458

    authors: Miller AT,Sandberg M,Huang YH,Young M,Sutton S,Sauer K,Cooke MP

    更新日期:2007-05-01 00:00:00

  • Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis.

    abstract::Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood. Dividing lymphocytes typically rely on aerobic glycolysis over oxidative phosphorylation for energy. Here we report that GCBCs are exceptional amo...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/s41590-020-0598-4

    authors: Weisel FJ,Mullett SJ,Elsner RA,Menk AV,Trivedi N,Luo W,Wikenheiser D,Hawse WF,Chikina M,Smita S,Conter LJ,Joachim SM,Wendell SG,Jurczak MJ,Winkler TH,Delgoffe GM,Shlomchik MJ

    更新日期:2020-03-01 00:00:00

  • Mechanosensing through immunoreceptors.

    abstract::The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors, whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of m...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/s41590-019-0491-1

    authors: Zhu C,Chen W,Lou J,Rittase W,Li K

    更新日期:2019-10-01 00:00:00

  • An innate antiviral pathway acting before interferons at epithelial surfaces.

    abstract::Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.3319

    authors: Iversen MB,Reinert LS,Thomsen MK,Bagdonaite I,Nandakumar R,Cheshenko N,Prabakaran T,Vakhrushev SY,Krzyzowska M,Kratholm SK,Ruiz-Perez F,Petersen SV,Goriely S,Bibby BM,Eriksson K,Ruland J,Thomsen AR,Herold BC,Wandall H

    更新日期:2016-02-01 00:00:00

  • A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells.

    abstract::Beyond its well-characterized functions in antibody diversification, the cytidine deaminase AID can catalyze off-target DNA damage and has been hypothesized to edit RNA and mediate DNA demethylation. To comprehensively examine the effects of AID on the transcriptome and the pattern of DNA methylation ('methylome'), we...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.2616

    authors: Fritz EL,Rosenberg BR,Lay K,Mihailović A,Tuschl T,Papavasiliou FN

    更新日期:2013-07-01 00:00:00

  • Diversity of receptors binding HIV on dendritic cell subsets.

    abstract::The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated T cells in the lymph node may be crucial in early HIV-1 pathogenesis. We have characterized primary DCs for the receptors involved in viral envelope attachment and observed that C-type lectin receptor (CLR) binding was p...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni841

    authors: Turville SG,Cameron PU,Handley A,Lin G,Pöhlmann S,Doms RW,Cunningham AL

    更新日期:2002-10-01 00:00:00

  • Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells.

    abstract::Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation. However, it is not known why CD4(+) T cells undergo less-efficient homeostatic proliferation than CD8(+) T cells do. Here we show that systemic IL-7 concentrations increased during ly...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.1695

    authors: Guimond M,Veenstra RG,Grindler DJ,Zhang H,Cui Y,Murphy RD,Kim SY,Na R,Hennighausen L,Kurtulus S,Erman B,Matzinger P,Merchant MS,Mackall CL

    更新日期:2009-02-01 00:00:00

  • TCR sequencing paired with massively parallel 3' RNA-seq reveals clonotypic T cell signatures.

    abstract::High-throughput 3' single-cell RNA-sequencing (scRNA-seq) allows cost-effective, detailed characterization of individual immune cells from tissues. Current techniques, however, are limited in their ability to elucidate essential immune cell features, including variable sequences of T cell antigen receptors (TCRs) that...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/s41590-019-0544-5

    authors: Tu AA,Gierahn TM,Monian B,Morgan DM,Mehta NK,Ruiter B,Shreffler WG,Shalek AK,Love JC

    更新日期:2019-12-01 00:00:00

  • CSF-1R, DAP12 and beta-catenin: a ménage à trois.

    abstract::DAP12-coupled receptors influence signals emanating from Toll-like receptors, integrins and receptors for cytokines and growth factors. New findings indicate that DAP12 also facilitates the ability of CSF-1R, the receptor for M-CSF, to induce the stabilization and nuclear translocation of beta-catenin. ...

    journal_title:Nature immunology

    pub_type: 新闻

    doi:10.1038/ni0709-681

    authors: McVicar DW,Trinchieri G

    更新日期:2009-07-01 00:00:00

  • Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.

    abstract::After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putati...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.2536

    authors: Best JA,Blair DA,Knell J,Yang E,Mayya V,Doedens A,Dustin ML,Goldrath AW,Immunological Genome Project Consortium.

    更新日期:2013-04-01 00:00:00

  • Different molecular complexes that mediate transcriptional induction and repression by FoxP3.

    abstract::FoxP3 conditions the transcriptional signature and functional facets of regulatory T cells (Treg cells). Its mechanism of action, whether as an activator or a repressor, has remained unclear. Here, chromatin analysis showed that FoxP3 bound active enhancer elements, not repressed chromatin, around loci over- or under-...

    journal_title:Nature immunology

    pub_type: 杂志文章

    doi:10.1038/ni.3835

    authors: Kwon HK,Chen HM,Mathis D,Benoist C

    更新日期:2017-11-01 00:00:00