Abstract:
:The molecular mechanisms underlying the differentiation of interleukin 17-producing T helper cells (T(H)-17 cells) are still poorly understood. Here we show that optimal transcription of the gene encoding interleukin 17 (Il17) required a 2-kilobase promoter and at least one conserved noncoding (enhancer) sequence, CNS-5. Both cis-regulatory elements contained regions that bound the transcription factors RORgammat and Runx1. Runx1 influenced T(H)-17 differentiation by inducing RORgammat expression and by binding to and acting together with RORgammat during Il17 transcription. However, Runx1 also interacts with the transcription factor Foxp3, and this interaction was necessary for the negative effect of Foxp3 on T(H)-17 differentiation. Thus, our data support a model in which the differential association of Runx1 with Foxp3 and with RORgammat regulates T(H)-17 differentiation.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Zhang F,Meng G,Strober Wdoi
10.1038/ni.1663subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1297-306issue
11eissn
1529-2908issn
1529-2916pii
ni.1663journal_volume
9pub_type
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abstract:: ...
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