Abstract:
:Store-operated Ca2+ entry through calcium release-activated calcium channels is the chief mechanism for increasing intracellular Ca2+ in immune cells. Here we show that mouse T cells and fibroblasts lacking the calcium sensor STIM1 had severely impaired store-operated Ca2+ influx, whereas deficiency in the calcium sensor STIM2 had a smaller effect. However, T cells lacking either STIM1 or STIM2 had much less cytokine production and nuclear translocation of the transcription factor NFAT. T cell-specific ablation of both STIM1 and STIM2 resulted in a notable lymphoproliferative phenotype and a selective decrease in regulatory T cell numbers. We conclude that both STIM1 and STIM2 promote store-operated Ca2+ entry into T cells and fibroblasts and that STIM proteins are required for the development and function of regulatory T cells.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Oh-Hora M,Yamashita M,Hogan PG,Sharma S,Lamperti E,Chung W,Prakriya M,Feske S,Rao Adoi
10.1038/ni1574subject
Has Abstractpub_date
2008-04-01 00:00:00pages
432-43issue
4eissn
1529-2908issn
1529-2916pii
ni1574journal_volume
9pub_type
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