Abstract:
:Cell fate 'decisions' involving multipotential progenitors seem to be 'dictated' by threshold activities of lineage-determining transcription factors. Such 'decisions' are now shown to be reinforced by the induction of secondary transcription factors that act in concert with the primary regulators.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Singh Hdoi
10.1038/ni0207-119subject
Has Abstractpub_date
2007-02-01 00:00:00pages
119-20issue
2eissn
1529-2908issn
1529-2916pii
ni0207-119journal_volume
8pub_type
评论,新闻abstract::Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monoc...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-019-0568-x
更新日期:2020-02-01 00:00:00
abstract::Genes and pathways in which inactivation dampens tissue inflammation present new opportunities for understanding the pathogenesis of common human inflammatory diseases, including inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis. We identified a mutation in the gene encoding the deubiquitination ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3581
更新日期:2017-01-01 00:00:00
abstract::CD160, a glycosylphosphatidylinositol-anchored member of the immunoglobulin superfamily, is expressed on both cytolytic lymphocytes and some unstimulated CD4+ T cells. Here we show that CD160 expression was increased after activation of human CD4+ T cells and that crosslinking CD160 with monoclonal antibody strongly i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1554
更新日期:2008-02-01 00:00:00
abstract::CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T cells with precursor characteristics that self-renew and depend on the ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0760-z
更新日期:2020-10-01 00:00:00
abstract::Ebola virus is a highly virulent pathogen capable of inducing a frequently lethal hemorrhagic fever syndrome. Accumulating evidence indicates that the virus actively subverts both innate and adaptive immune responses and triggers harmful inflammatory responses as it inflicts direct tissue damage. The host immune syste...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1519
更新日期:2007-11-01 00:00:00
abstract::In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2981
更新日期:2014-10-01 00:00:00
abstract::The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a complex phenotype determined by interactions among the pathogen, the human host and the surrounding environment. An impact of host genetic variation on HIV-1 susceptibility was identified early in the pandemic, with a major role attr...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.3147
更新日期:2015-06-01 00:00:00
abstract::The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we iden...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1085
更新日期:2004-07-01 00:00:00
abstract::The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs). However, the metabolic requirements that support this process remain poorly defined. We found that DC glycolytic flux increased within minutes of exposure to TLR agonists and that this served an essential role in supporting ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2833
更新日期:2014-04-01 00:00:00
abstract::CD1 proteins present various glycolipid antigens to T cells, but the cellular mechanisms that control which particular glycolipids generate T cell responses are not understood. We show here that T cell recognition of glucose monomycolate antigens with long (C(80)) alkyl chains involves the delivery of CD1b proteins an...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni780
更新日期:2002-05-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-019-0554-3
更新日期:2020-01-01 00:00:00
abstract::Macrophages infected with human immunodeficiency virus type 1 emit long intercellular conduits that shuttle the viral protein Nef to bystander B cells, where it impairs cellular function and immunoglobulin class switching. ...
journal_title:Nature immunology
pub_type: 新闻
doi:10.1038/ni0909-933
更新日期:2009-09-01 00:00:00
abstract::The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and cytokine-mediated activation of the transcription factor NF-kappaB; however, little is known about the mechanisms of A20-mediated inactivation of signaling intermediates such as RIP1. Here we demonstrate that the regulatory molecule ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1563
更新日期:2008-03-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-019-0531-x
更新日期:2019-11-01 00:00:00
abstract::The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against influenza. Here we designed a vaccine using the hypervariable recepto...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0305-x
更新日期:2019-03-01 00:00:00
abstract::B lymphocyte development and selection are central to adaptive immunity and self-tolerance. These processes require B cell receptor (BCR) signaling and occur in bone marrow, an environment with variable hypoxia, but whether hypoxia-inducible factor (HIF) is involved is unknown. We show that HIF activity is high in hum...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0772-8
更新日期:2020-11-01 00:00:00
abstract::The complex heterogeneity of cells, and their interconnectedness with each other, are major challenges to identifying clinically relevant measurements that reflect the state and capability of the immune system. Highly multiplexed, single-cell technologies may be critical for identifying correlates of disease or immuno...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2796
更新日期:2014-02-01 00:00:00
abstract::Using both 'reverse genetics' and structural analysis, we have examined the in vivo relationship between antigenicity and T cell receptor (TCR) repertoire diversity. Influenza A virus infection of C57BL/6 mice induces profoundly different TCR repertoires specific for the nucleoprotein peptide of amino acids 366-374 (N...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1175
更新日期:2005-04-01 00:00:00
abstract::Beyond its well-characterized functions in antibody diversification, the cytidine deaminase AID can catalyze off-target DNA damage and has been hypothesized to edit RNA and mediate DNA demethylation. To comprehensively examine the effects of AID on the transcriptome and the pattern of DNA methylation ('methylome'), we...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2616
更新日期:2013-07-01 00:00:00
abstract::Group 2 innate lymphoid cells (ILC2s) and CD4+ type 2 helper T cells (TH2 cells) are defined by their similar effector cytokines, which together mediate the features of allergic immunity. We found that tissue ILC2s and TH2 cells differentiated independently but shared overlapping effector function programs that were m...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3582
更新日期:2016-12-01 00:00:00
abstract::We define here the specificity and significance of proteases in the endoplasmic reticulum (ER) that generate peptides for presentation by major histocompatibility complex (MHC) class I molecules. We show that aminopeptidases efficiently trimmed all residues except proline that flank the NH2-termini of antigenic precur...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/89800
更新日期:2001-07-01 00:00:00
abstract::The duration of T cell receptor (TCR) signaling is thought to be important for thymocyte differentiation into the CD4 or CD8 lineage. However, the in vivo relevance of this hypothesis is unclear. Here we divided T cell positive selection into genetically separable developmental steps by confining TCR signal transducti...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1040
更新日期:2004-03-01 00:00:00
abstract::The prevalence of autoimmune disorders in affluent countries has reached epidemic proportions. Over the past 50 years, a reverse trend between the frequency of infectious diseases and the incidence of autoimmune and allergic diseases led to the so-called 'hygiene hypothesis'. Given the epidemiological evidence and rec...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3851
更新日期:2017-10-18 00:00:00
abstract::Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-beta (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni910
更新日期:2003-05-01 00:00:00
abstract::T lymphocytes and B lymphocytes integrate activating signals to control the size of their proliferative response. Here we report that such control was achieved by timed changes in the production rate of cell-cycle-regulating proto-oncoprotein Myc, with division cessation occurring when Myc levels fell below a critical...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3598
更新日期:2017-01-01 00:00:00
abstract::We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 (tentati...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni875
更新日期:2003-01-01 00:00:00
abstract::Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/s41590-017-0022-x
更新日期:2018-02-01 00:00:00
abstract::Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptive immunity. Although intense effort has been devoted to studying the regulation and requirements...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1201-1103
更新日期:2001-12-01 00:00:00
abstract::Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T (Treg) cells as a distinct, highly suppressive population of Treg cells that mediate wound healing. These Treg cells were enriched in intestinal...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0230-z
更新日期:2018-12-01 00:00:00
abstract::Cysteinyl leukotrienes are established mediators of bronchial asthma and have agonist roles analogous to those of histamine in allergic rhinitis. We now know that the substance originally termed slow-reacting substance of anaphylaxis was composed of three cysteinyl leukotrienes that act in the inflammatory response vi...
journal_title:Nature immunology
pub_type: 历史文章,杂志文章
doi:10.1038/ni0208-113
更新日期:2008-02-01 00:00:00