Abstract:
:The duration of T cell receptor (TCR) signaling is thought to be important for thymocyte differentiation into the CD4 or CD8 lineage. However, the in vivo relevance of this hypothesis is unclear. Here we divided T cell positive selection into genetically separable developmental steps by confining TCR signal transduction to discrete thymocyte developmental windows. TCR signals confined to the double-positive thymocyte stage promoted CD8, but not CD4, lineage differentiation. Major histocompatibility complex (MHC) class II-restricted thymocytes were, instead, redirected into the CD8 lineage. These findings support the hypothesis that distinct kinetics of MHC class I- and MHC class II-induced TCR signals direct intrathymic developmental decisions.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Liu X,Bosselut Rdoi
10.1038/ni1040keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
280-8issue
3eissn
1529-2908issn
1529-2916pii
ni1040journal_volume
5pub_type
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更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章,已发布勘误
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abstract::CD160, a glycosylphosphatidylinositol-anchored member of the immunoglobulin superfamily, is expressed on both cytolytic lymphocytes and some unstimulated CD4+ T cells. Here we show that CD160 expression was increased after activation of human CD4+ T cells and that crosslinking CD160 with monoclonal antibody strongly i...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni778
更新日期:2002-05-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1020
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/76957
更新日期:2000-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1201-1103
更新日期:2001-12-01 00:00:00
abstract::Neutrophils encounter and 'prioritize' many chemoattractants in their pursuit of bacteria. Here we tested the possibility that the phosphatase PTEN is responsible for the prioritization of chemoattractants. Neutrophils induced chemotaxis by two separate pathways, the phosphatidylinositol-3-OH kinase (PI(3)K) phosphata...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1623
更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41590-018-0083-5
更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/ni907
更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/ni830
更新日期:2002-09-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2018
更新日期:2011-06-01 00:00:00
abstract::Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-beta (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni910
更新日期:2003-05-01 00:00:00
abstract::The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-1(hi)CD25(hi) (Triple(hi)) Treg cells were highly self-reactive and c...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3522
更新日期:2016-09-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-019-0582-z
更新日期:2020-02-01 00:00:00
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journal_title:Nature immunology
pub_type: 历史文章,杂志文章
doi:10.1038/ni0208-113
更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1422
更新日期:2007-02-01 00:00:00